PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26740398-7 2016 Specifically, opiates in several CNS regions including NAc, and cocaine more selectively in NAc, induce expression of certain adenylyl cyclase isoforms and PKA subunits via the transcription factor, CREB, and these transcriptional adaptations serve a homeostatic function to oppose drug action. Opiate Alkaloids 14-21 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 156-159