PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
855909-2	1977	The inhibition by pancuronium of acetylcholinesterase (AChE) and of plasma cholinesterase (ChE) was investigated in vitro regarding a) the sensitivity of both enzymes; b) the mechanism and constants of inhibition; and c) the relationship between the neuromuscular blocking and the anticholinesterase activity of pancuronium.	Pancuronium	18-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	33-53	
855909-2	1977	The inhibition by pancuronium of acetylcholinesterase (AChE) and of plasma cholinesterase (ChE) was investigated in vitro regarding a) the sensitivity of both enzymes; b) the mechanism and constants of inhibition; and c) the relationship between the neuromuscular blocking and the anticholinesterase activity of pancuronium.	Pancuronium	18-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-59	
855909-4	1977	Pancuronium is a reversible inhibitor of both AChE and ChE.	Pancuronium	0-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50	
855909-9	1977	The inhibition of AChE and ChE is thought to be induced by a reversible binding of pancuronium to the anionic subsite of the active center, thus decreasing the formation of the primary enzyme-substrate complex.	Pancuronium	83-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-22	
136679-0	1976	[Serum acetylcholinesterase changes after pancuronium administration].	Pancuronium	42-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	7-27	
136679-3	1976	The enzyme concentrations were lower in those patients that had also received Pancuronium, suggesting a cummulative inhibitory effect on serum acetylcholinesterase.	Pancuronium	78-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-163	
1191483-5	1975	Pancuronium inhibition of the acetylcholinesterase in human red blood cells and from the electric eel was more than one thousand times weaker.	Pancuronium	0-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-50	
14564607-1	2000	PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients.	Pancuronium	164-175	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-113	
14564607-6	2000	The apparent inhibition constants (K(i)) of pancuronium (8.72 x 10(-8) M) and vecuronium (3.53 x 10(-7) M) for plasma ChE inhibition were lower than that of neostigmine (7.36 x 10(-7) M), whereas those of the six nondepolarizing NMBAs for erythrocyte AChE were markedly higher than that of neostigmine.	Pancuronium	44-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	251-255	
14564607-1	2000	PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients.	Pancuronium	164-175	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119	
7643875-7	1995	In the patient controls, pancuronium 4 mg induced a severe neuromuscular block but not with 1 and 2 mg. Pancuronium dosages necessary to reverse severe OP-induced neuromuscular blockade produce a neuromuscular block when AChE activity is normal.	Pancuronium	25-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	221-225	
7643875-7	1995	In the patient controls, pancuronium 4 mg induced a severe neuromuscular block but not with 1 and 2 mg. Pancuronium dosages necessary to reverse severe OP-induced neuromuscular blockade produce a neuromuscular block when AChE activity is normal.	Pancuronium	104-115	acetylcholinesterase (Cartwright blood group)	Homo sapiens	221-225