PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31514980-1 2019 Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells. Monocrotaline 90-103 solute carrier family 22 member 1 Homo sapiens 137-147 31514980-5 2019 Monocrotaline was determined to be a substrate of both OCT1 (Km = 109.1 +- 17.8 micromol L-1, Vmax = 576.5 +- 87.5 pmol/mg protein/min) and OCT2 (Km = 64.7 +- 14.8 micromol L-1, Vmax = 180.7 +- 22.0 pmol/mg protein/min), other than OCT3 and MATE transporters. Monocrotaline 0-13 solute carrier family 22 member 1 Homo sapiens 55-59 23831208-6 2013 Moreover, the OCT1 inhibitors, such as quinidine, d-tetrahydropalmatine (d-THP), obviously inhibited the uptake of MCT in MDCK-hOCT1 cells and isolated rat primary hepatocytes, and attenuated the viability reduction and LDH release of the primary cultured rat hepatocytes caused by MCT. Monocrotaline 115-118 solute carrier family 22 member 1 Homo sapiens 127-132