PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1886888-0 1991 Role of cholecystokinin in pancreatic bicarbonate secretion in dogs. Bicarbonates 38-49 cholecystokinin Canis lupus familiaris 8-23 7479678-4 1995 The infusion of secretin and CCK resulted in a significant increase in pancreatic bicarbonate and protein secretion during the infusion of NRS, whereas the pancreatic secretory response of bicarbonate and protein was profoundly suppressed by the infusion of Anti-I in six pancreata so studied. Bicarbonates 82-93 cholecystokinin Canis lupus familiaris 29-32 7479678-4 1995 The infusion of secretin and CCK resulted in a significant increase in pancreatic bicarbonate and protein secretion during the infusion of NRS, whereas the pancreatic secretory response of bicarbonate and protein was profoundly suppressed by the infusion of Anti-I in six pancreata so studied. Bicarbonates 189-200 cholecystokinin Canis lupus familiaris 29-32 7479678-7 1995 These results indicate that secretin- and CCK-stimulated pancreatic secretion of bicarbonate and protein depends heavily on local action of insulin. Bicarbonates 81-92 cholecystokinin Canis lupus familiaris 42-45 8108365-8 1994 The study indicates that endogenous CCK released by protein digests exerts not only enzyme secretion but also bicarbonate secretion in dogs. Bicarbonates 110-121 cholecystokinin Canis lupus familiaris 36-39 8927624-8 1996 Potentiation of CCK-induced bicarbonate output by secretin was also unaffected by atropine and denervation. Bicarbonates 28-39 cholecystokinin Canis lupus familiaris 16-19 8927624-10 1996 Further, potentiation of CCK-induced bicarbonate output by secretin does not depend on extrinsic neural or cholinergic elements. Bicarbonates 37-48 cholecystokinin Canis lupus familiaris 25-28 7716143-5 1995 The secretin/cholecystokinin-induced bicarbonate and protein outputs were significantly inhibited by PYY in both the innervated and denervated animals. Bicarbonates 37-48 cholecystokinin Canis lupus familiaris 13-28 7517543-6 1994 Galanin inhibited meal-, CCK-, and secretin-induced bicarbonate outputs in both the innervated and denervated pancreas. Bicarbonates 52-63 cholecystokinin Canis lupus familiaris 25-28 8302798-9 1993 Potentiation of secretin-induced bicarbonate output by CCK, however, is not dependent on neural mediation. Bicarbonates 33-44 cholecystokinin Canis lupus familiaris 55-58 1886888-8 1991 The stimulatory effect as well as potentiating effect of CCK on pancreatic bicarbonate secretion was blocked by infusion of proglumide. Bicarbonates 75-86 cholecystokinin Canis lupus familiaris 57-60 1886888-3 1991 Increase in pancreatic secretion of both bicarbonate and protein was accompanied by the increase in plasma CCK concentration. Bicarbonates 41-52 cholecystokinin Canis lupus familiaris 107-110 1886888-4 1991 However, the increase in bicarbonate as well as protein secretion was blocked by proglumide, a CCK antagonist, given intravenously. Bicarbonates 25-36 cholecystokinin Canis lupus familiaris 95-98 1886888-6 1991 These observations indicate that endogenous CCK plays an important role in secretion of both bicarbonate and protein stimulated by digested corn oil. Bicarbonates 93-104 cholecystokinin Canis lupus familiaris 44-47 1886888-7 1991 In a group of four dogs with pancreatic fistulas, intravenous infusion of CCK potentiated the stimulatory effect of secretin on pancreatic bicarbonate secretion. Bicarbonates 139-150 cholecystokinin Canis lupus familiaris 74-77 3876499-3 1985 CRF stimulated pancreatic bicarbonate and protein secretion under basal conditions and in response to secretin or cholecystokinin (CCK). Bicarbonates 26-37 cholecystokinin Canis lupus familiaris 131-134 3336811-8 1988 Incremental bicarbonate responses to intravenous CCK-8 alone were compared with intravenous CCK-8 plus intravenous neurotensin. Bicarbonates 12-23 cholecystokinin Canis lupus familiaris 49-52 3628230-5 1987 Pretreatment with S5 enhanced secretin/CCK-induced bicarbonate outputs; protein outputs did not differ. Bicarbonates 51-62 cholecystokinin Canis lupus familiaris 39-42 2469109-4 1989 in graded doses in dogs caused a small but significant stimulation of pancreatic HCO3- and protein outputs and potentiated secretin- and cholecystokinin (CCK)-induced pancreatic HCO3- but not protein secretion. Bicarbonates 178-182 cholecystokinin Canis lupus familiaris 137-152 2469109-4 1989 in graded doses in dogs caused a small but significant stimulation of pancreatic HCO3- and protein outputs and potentiated secretin- and cholecystokinin (CCK)-induced pancreatic HCO3- but not protein secretion. Bicarbonates 178-182 cholecystokinin Canis lupus familiaris 154-157 2469109-7 1989 This study indicates that GRF in vivo stimulates basal and augments secretin- or CCK-induced pancreatic HCO3- secretion and that this is probably due to direct stimulatory action of the peptide on pancreatic secretory cells. Bicarbonates 104-108 cholecystokinin Canis lupus familiaris 81-84 2461609-2 1988 In vitro assessment was performed by evaluating the effect of terbutaline on 10(-8) OP-CCK stimulated amylase release of pancreatic tissue slices incubated at 37 degrees C in Krebs-bicarbonate media. Bicarbonates 181-192 cholecystokinin Canis lupus familiaris 87-90 2461609-6 1988 Following the terbutaline infusion, there was also a significant decrease in OP-CCK-stimulated amylase (140.3 +/- 23.3 vs. 24.6 +/- 11.9; P less than 0.005) and bicarbonate release (.069 +/- .03 vs. .003 +/- .001; P less than 0.05). Bicarbonates 161-172 cholecystokinin Canis lupus familiaris 80-83 3706524-4 1986 These fasting bicarbonate and protein peaks reached, respectively, approximately 9 and 30% of the highest postprandial outputs and 4 and 14% of the maximal secretory capacity elicited by secretin or CCK. Bicarbonates 14-25 cholecystokinin Canis lupus familiaris 199-202 4014465-5 1985 Thus, in dogs, HCl in the duodenum releases both CCK and secretin to stimulate pancreatic secretion of bicarbonate as well as enzymes. Bicarbonates 103-114 cholecystokinin Canis lupus familiaris 49-52 625674-6 1978 Cholecystokinin induced pancreatic secretion contained less bicarbonate and more protein than secretin induced secretion. Bicarbonates 60-71 cholecystokinin Canis lupus familiaris 0-15 6305210-6 1983 Neurotensin, like oleate, potentiated the action of secretin and CCK on pancreatic bicarbonate and had additive effects on protein response to these secretagogues. Bicarbonates 83-94 cholecystokinin Canis lupus familiaris 65-68 553557-0 1979 [Variations of chlorides and bicarbonates in pancreatic juice in response to increasing doses of secretin and cholecystokinin]. Bicarbonates 29-41 cholecystokinin Canis lupus familiaris 110-126 2858160-4 1985 Pancreatic volume, protein, and bicarbonate outputs to all doses of CCK-OP were inhibited significantly (P less than 0.05) in a competitive manner, consistent with the proposed mode of action of proglumide. Bicarbonates 32-43 cholecystokinin Canis lupus familiaris 68-74 6322594-5 1984 When CCK-OP in four graded doses was added to intravenous infusion of secretin, 2.45 pmol X kg-1 X h-1, the actual bicarbonate output at each dose level of CCK-OP was greater than the sum of the bicarbonate outputs produced by secretin alone and CCK-OP alone in a corresponding dose. Bicarbonates 115-126 cholecystokinin Canis lupus familiaris 156-159 6322594-5 1984 When CCK-OP in four graded doses was added to intravenous infusion of secretin, 2.45 pmol X kg-1 X h-1, the actual bicarbonate output at each dose level of CCK-OP was greater than the sum of the bicarbonate outputs produced by secretin alone and CCK-OP alone in a corresponding dose. Bicarbonates 115-126 cholecystokinin Canis lupus familiaris 156-159 6322594-7 1984 The study indicates that, like secretin, CCK-OP is another necessary agent for pancreatic secretion of bicarbonate during digestion. Bicarbonates 103-114 cholecystokinin Canis lupus familiaris 41-44 918855-3 1977 OP-CCK increased volume and the outputs of bicarbonate and protein from the pancreas. Bicarbonates 43-54 cholecystokinin Canis lupus familiaris 3-6 4787845-0 1973 Pure cholecystokinin: pancreatic protein and bicarbonate response. Bicarbonates 45-56 cholecystokinin Canis lupus familiaris 5-20 4787845-2 1973 10% pure CCK gave higher bicarbonate output that can be achieved with pure CCK. Bicarbonates 25-36 cholecystokinin Canis lupus familiaris 9-12 4787845-2 1973 10% pure CCK gave higher bicarbonate output that can be achieved with pure CCK. Bicarbonates 25-36 cholecystokinin Canis lupus familiaris 75-78