PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19622732-2 2009 Here, we report the physiological role of the intracellular CAII isoform involvement in acid-, PGE(2,) and forskolin-induced murine duodenal bicarbonate secretion (DBS) in vivo. Bicarbonates 141-152 carbonic anhydrase 2 Mus musculus 60-64 19622732-11 2009 The results suggest that CA II is important for duodenocyte acidification by low luminal pH and for eliciting the acid-mediated HCO(3)(-) secretory response, but is not important in the generation of the secreted HCO(3)(-) ions. Bicarbonates 128-134 carbonic anhydrase 2 Mus musculus 25-30 18209476-1 2008 BACKGROUND/AIMS: Intercalated cells (ICs) of the kidney collecting duct are rich in carbonic anhydrase II (CAII), which facilitates proton and bicarbonate transport. Bicarbonates 143-154 carbonic anhydrase 2 Mus musculus 84-105 18209476-1 2008 BACKGROUND/AIMS: Intercalated cells (ICs) of the kidney collecting duct are rich in carbonic anhydrase II (CAII), which facilitates proton and bicarbonate transport. Bicarbonates 143-154 carbonic anhydrase 2 Mus musculus 107-111 10333352-2 1999 Carbonic anhydrase II, catalysing the synthesis of bicarbonate within spermatozoa, must play a significant role in these mechanisms. Bicarbonates 51-62 carbonic anhydrase 2 Mus musculus 0-21 17890222-8 2007 Anion exchanger activity was also significantly reduced in Car2-deficient mice, consistent with an important role of a putative Car2.Ae2 HCO(3)(-) transport metabolon in parotid exocrine cell function. Bicarbonates 137-143 carbonic anhydrase 2 Mus musculus 59-63 17890222-8 2007 Anion exchanger activity was also significantly reduced in Car2-deficient mice, consistent with an important role of a putative Car2.Ae2 HCO(3)(-) transport metabolon in parotid exocrine cell function. Bicarbonates 137-143 carbonic anhydrase 2 Mus musculus 128-132 9605187-1 1998 Carbonic anhydrase II (CA-II), an enzyme that catalyzes hydration of carbon dioxide to bicarbonate and hydrogen ions, is located exclusively in cholangiocytes in the liver. Bicarbonates 87-98 carbonic anhydrase 2 Mus musculus 23-28 9605187-1 1998 Carbonic anhydrase II (CA-II), an enzyme that catalyzes hydration of carbon dioxide to bicarbonate and hydrogen ions, is located exclusively in cholangiocytes in the liver. Bicarbonates 87-98 carbonic anhydrase 2 Mus musculus 0-21 8338133-11 1993 Similarly, cultures maintained in a low bicarbonate/CO2 media (GibCO2-I medium containing 1 mM bicarbonate under an atmosphere of 100% humidified air) displayed 30-50% lower CA II and CA III concentrations. Bicarbonates 40-51 carbonic anhydrase 2 Mus musculus 174-179 7616606-1 1995 In the choroid plexus carbonic anhydrase II (CAII) supports the transport of bicarbonate ions, sodium ions, and water from blood to the CSF, and in the myelin sheath CAII supports compaction of myelin by stimulating cotransport of ions and water out from between the myelin membranes. Bicarbonates 77-88 carbonic anhydrase 2 Mus musculus 22-43 7616606-1 1995 In the choroid plexus carbonic anhydrase II (CAII) supports the transport of bicarbonate ions, sodium ions, and water from blood to the CSF, and in the myelin sheath CAII supports compaction of myelin by stimulating cotransport of ions and water out from between the myelin membranes. Bicarbonates 77-88 carbonic anhydrase 2 Mus musculus 45-49 8338133-12 1993 Thus CA II and CA III concentrations are influenced by pH and bicarbonate/CO2. Bicarbonates 62-73 carbonic anhydrase 2 Mus musculus 5-10 8338133-11 1993 Similarly, cultures maintained in a low bicarbonate/CO2 media (GibCO2-I medium containing 1 mM bicarbonate under an atmosphere of 100% humidified air) displayed 30-50% lower CA II and CA III concentrations. Bicarbonates 95-106 carbonic anhydrase 2 Mus musculus 174-179 25820238-9 2015 Not only physicochemical H(+) buffering, but also rapid import of HCO3(-) via the electrogenic sodium-bicarbonate cotransporter NBCe1, supported by carbonic anhydrase II (CA II), was identified to enhance cytosolic H(+) buffer strength substantially. Bicarbonates 66-70 carbonic anhydrase 2 Mus musculus 148-169 26487715-7 2015 CAII and CAIV single knockout animals display an imbalanced HCO3 (-) homeostasis, resulting in substantially reduced sperm motility, swimming speed, and HCO3 (-)-enhanced beat frequency. Bicarbonates 60-64 carbonic anhydrase 2 Mus musculus 0-4 26487715-7 2015 CAII and CAIV single knockout animals display an imbalanced HCO3 (-) homeostasis, resulting in substantially reduced sperm motility, swimming speed, and HCO3 (-)-enhanced beat frequency. Bicarbonates 153-157 carbonic anhydrase 2 Mus musculus 0-4 26487715-10 2015 In comparison with sperm from CAII and CAIV double knockout animals, pharmacological loss of CAIV in sperm from CAII knockout animals, show an even lower response to HCO3 (-). Bicarbonates 166-170 carbonic anhydrase 2 Mus musculus 112-116 27981578-1 2017 KEY POINTS: The present study suggests that the electrogenic sodium-bicarbonate cotransporter, NBCe1, supported by carbonic anhydrase II, CAII, provides an efficient mechanism of bicarbonate sensing in cortical astrocytes. Bicarbonates 68-79 carbonic anhydrase 2 Mus musculus 115-136 27981578-1 2017 KEY POINTS: The present study suggests that the electrogenic sodium-bicarbonate cotransporter, NBCe1, supported by carbonic anhydrase II, CAII, provides an efficient mechanism of bicarbonate sensing in cortical astrocytes. Bicarbonates 68-79 carbonic anhydrase 2 Mus musculus 138-142 25820238-9 2015 Not only physicochemical H(+) buffering, but also rapid import of HCO3(-) via the electrogenic sodium-bicarbonate cotransporter NBCe1, supported by carbonic anhydrase II (CA II), was identified to enhance cytosolic H(+) buffer strength substantially. Bicarbonates 66-70 carbonic anhydrase 2 Mus musculus 171-176 23874305-4 2013 In fact, it was found that in this region multiple cells express elements which are relevant for the secretion of bicarbonate, including carbonic anhydrase (CAII), the cystic fibrosis transmembrane conductance regulator (CFTR) and the Na(+)/H(+) exchanger (NHE1). Bicarbonates 114-125 carbonic anhydrase 2 Mus musculus 157-161 25990710-4 2015 NBCe1-mediated H(+) i regulation from alkalosis was dominant, with the support of intracellular carbonic anhydrase II, even when the intra- and extracellular [HCO3 (-) ] was very low (<1mM), as in nominally CO2 /HCO3 (-) free condition. Bicarbonates 215-219 carbonic anhydrase 2 Mus musculus 96-117 24233434-8 2014 Even in the absence of luminal Cl-, luminal CO2/HCO3 - augmented fluid absorption in WT, CAII, NHE2- or DRA-deficient, but not in PAT-1- or NHE3-deficient mice, indicating the likelihood that PAT-1 serves to import HCO3 - and NHE3 serves to import Na+ under these circumstances. Bicarbonates 48-52 carbonic anhydrase 2 Mus musculus 89-93 24233434-9 2014 The results suggest that PAT-1 plays an important role in jejunal Na+HCO3 - reabsorption, while DRA absorbs Cl- and exports HCO3 - in a partly CAII-dependent fashion. Bicarbonates 124-128 carbonic anhydrase 2 Mus musculus 143-147 24361611-1 2014 BACKGROUND: The hydration of CO2 catalyzed by the ubiquitous carbonic anhydrase 2 (Ca2) is central for bicarbonate transport, bone metabolism and acid-base homeostasis in metazoans. Bicarbonates 103-114 carbonic anhydrase 2 Mus musculus 61-81 24361611-1 2014 BACKGROUND: The hydration of CO2 catalyzed by the ubiquitous carbonic anhydrase 2 (Ca2) is central for bicarbonate transport, bone metabolism and acid-base homeostasis in metazoans. Bicarbonates 103-114 carbonic anhydrase 2 Mus musculus 83-86 24361611-7 2014 Surprisingly, inhibition of the bicarbonate-sensitive soluble adenylyl cyclase (sAC) was found to reduce CA2 expression instead of increasing it. Bicarbonates 32-43 carbonic anhydrase 2 Mus musculus 105-108 23210439-3 2012 Carbonic anhydrase II (CAII) provides substrates for these transporters (protons and bicarbonate, respectively). Bicarbonates 85-96 carbonic anhydrase 2 Mus musculus 0-21 23210439-3 2012 Carbonic anhydrase II (CAII) provides substrates for these transporters (protons and bicarbonate, respectively). Bicarbonates 85-96 carbonic anhydrase 2 Mus musculus 23-27 22653892-9 2012 The expression of genes involved in bicarbonate production (Car2) and transport (Slc4a4), as well as in enamel matrix endocytosis (Lamp1), was greater during the dark period, indicating that ameloblasts express these proteins when Amelx expression is at the nadir. Bicarbonates 36-47 carbonic anhydrase 2 Mus musculus 60-64