PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11928941-9	2002	The acquired enzymatic injury resulting from the inhibition of mitochondrial carbonic anhydrase V that provides bicarbonate to pyruvate carboxylase can produce tricarboxylic acid cycle damage.	Bicarbonates	112-123	carbonic anhydrase 5A	Homo sapiens	77-97	
10082753-9	1999	We propose that mitochondrial CA V participates in the detoxification of ammonia produced in the gastrointestinal tract by providing bicarbonate to carbamyl phosphate synthetase I.	Bicarbonates	133-144	carbonic anhydrase 5A	Homo sapiens	30-34	
11140614-4	2000	The mechanism of antitumor action with these sulfonamides is unknown, but it might involve either inhibition of several CA isozymes (such as CA IX, CA XII, CA XIV) predominantly present in tumor cells, a reduced provision of bicarbonate for the nucleotide synthesis (mediated by carbamoyl phosphate synthetase II), the acidification of the intracellular milieu as a consequence of CA inhibition or uncoupling of mitochondria and potent CA V inhibition among others.	Bicarbonates	225-236	carbonic anhydrase 5A	Homo sapiens	436-440	
19539481-6	2009	As hCA VA/VB are involved in several biosynthetic processes catalyzed by pyruvate carboxylase, acetyl CoA carboxylase, and carbamoyl phosphate synthetases I and II, providing the bicarbonate substrate to these carboxylating enzymes involved in fatty acid biosynthesis, their selective inhibition may lead to the development of antiobesity agents possessing a new mechanism of action.	Bicarbonates	179-190	carbonic anhydrase 5A	Homo sapiens	3-9	
26913920-1	2016	PURPOSE: Four mitochondrial metabolic liver enzymes require bicarbonate, which is provided by the carbonic anhydrase isoforms VA (CAVA) and VB (CAVB).	Bicarbonates	60-71	carbonic anhydrase 5A	Homo sapiens	130-134	
28330086-1	2016	Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme that catalyzes the reversible hydration of CO2 to produce HCO3- and proton.	Bicarbonates	113-117	carbonic anhydrase 5A	Homo sapiens	0-21	
28330086-1	2016	Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme that catalyzes the reversible hydration of CO2 to produce HCO3- and proton.	Bicarbonates	113-117	carbonic anhydrase 5A	Homo sapiens	23-27	
28330086-2	2016	CAV is primarily involved in several biosynthetic processes such as ureagenesis, gluconeogenesis and lipogenesis by providing bicarbonate ion.	Bicarbonates	126-137	carbonic anhydrase 5A	Homo sapiens	0-3	
9523771-2	1997	They may be broadly recognized according to the efficiency with which they catalyze the reversible interconversion of CO2 and HCO3-, and they differ in physicochemical properties, in sensitivity to various inhibitors and in their subcellular localization; cytoplasmic (CA I, CA II, CA III, and CA VII), cell-surface membrane (CA IV), and mitochondrial (CA V) and secretory (CA VI) isoenzymes have been described.	Bicarbonates	126-130	carbonic anhydrase 5A	Homo sapiens	294-298	
15501038-7	2004	It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase).	Bicarbonates	86-97	carbonic anhydrase 5A	Homo sapiens	52-57	
15501038-7	2004	It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase).	Bicarbonates	86-97	carbonic anhydrase 5A	Homo sapiens	285-290