PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32869704-0	2020	Deoxycholic Acid Upregulates the Reprogramming Factors KFL4 and OCT4 Through the IL-6/STAT3 Pathway in Esophageal Adenocarcinoma Cells.	Deoxycholic Acid	0-16	interleukin 6	Homo sapiens	81-85	
24096876-10	2014	mRNA and protein expression of TNF-alpha, IL-8, and IL-6 in cells treated with DCA alone were up-regulated, and intra-cellular ROS and p-NF-kappaB p65 protein levels were also increased.	Deoxycholic Acid	79-82	interleukin 6	Homo sapiens	52-56	
21055228-8	2010	CONCLUSIONS: Free bile acids (CA, DCA and CDCA) can inhibit the expression of IL-6 and the cell viability, while glycine conjugates (GCA, GDCA and GCDCA) can promote the expression of IL-6 and the cell viability.	Deoxycholic Acid	34-37	interleukin 6	Homo sapiens	78-82	
34438042-2	2021	Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells.	Deoxycholic Acid	52-68	interleukin 6	Homo sapiens	105-109	
34438042-2	2021	Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells.	Deoxycholic Acid	70-73	interleukin 6	Homo sapiens	105-109	
34438042-3	2021	DCA-induced production of IL-6 and IL-8 was attenuated by pharmacologic inhibition of the Protein Kinase C (PKC), MAP kinase, tyrosine kinase pathways, by the cholesterol sequestering agent, methyl-beta-cyclodextrin (MCD) and by the hydrophilic bile acid, ursodeoxycholic acid (UDCA).	Deoxycholic Acid	0-3	interleukin 6	Homo sapiens	26-30	
34438042-4	2021	The cholesterol-interacting agent, nystatin, which binds cholesterol without removing it from the membrane, synergized with DCA to induce IL-6 and IL-8.	Deoxycholic Acid	124-127	interleukin 6	Homo sapiens	138-142	
34438042-8	2021	Taken together, these results demonstrate that DCA stimulates IL-6 and IL-8 production in oesophageal cells via lipid raft-associated signaling.	Deoxycholic Acid	47-50	interleukin 6	Homo sapiens	62-66	
32869704-3	2020	In the present study, deoxycholic acid was used to investigate whether it could induce the expression of reprogramming factors Kruppel-like factor, OCT4, and Nanog; the transformation to cancer stem cells in esophageal adenocarcinoma; and the involvement of the interleukin-6/signal transduction and activation of transcription 3 inflammatory signaling pathway.	Deoxycholic Acid	22-38	interleukin 6	Homo sapiens	262-275	
32869704-7	2020	Results showed that deoxycholic acid promotes the expression of reprogramming factors Kruppel-like factor and OCT4, which are regulated by the interleukin-6/signal transduction and activation of transcription 3 signaling pathway.	Deoxycholic Acid	20-36	interleukin 6	Homo sapiens	143-156