PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23550028-0	2013	2-hydroxy-3-methylanthraquinone from Hedyotis diffusa Willd induces apoptosis in human leukemic U937 cells through modulation of MAPK pathways.	2-hydroxy-3-methylanthraquinone	0-31	mitogen-activated protein kinase 3	Homo sapiens	129-133	
23550028-4	2013	The current study determines the role of mitogen-activated protein kinases (MAPK) in human leukemic U937 cells apoptosis induced by 2-hydroxy-3-methylanthraquinone from H. diffusa.	2-hydroxy-3-methylanthraquinone	132-163	mitogen-activated protein kinase 3	Homo sapiens	76-80	
23550028-5	2013	Our results showed that 2-hydroxy-3-methylanthraquinone decreased phosphorylation-ERK1/2 (p-ERK1/2), and increased p-p38MAPK, but did not affect expressions of p-JNK1/2 in U937 cells.	2-hydroxy-3-methylanthraquinone	24-55	mitogen-activated protein kinase 3	Homo sapiens	82-88	
23550028-5	2013	Our results showed that 2-hydroxy-3-methylanthraquinone decreased phosphorylation-ERK1/2 (p-ERK1/2), and increased p-p38MAPK, but did not affect expressions of p-JNK1/2 in U937 cells.	2-hydroxy-3-methylanthraquinone	24-55	mitogen-activated protein kinase 3	Homo sapiens	92-98	
23550028-7	2013	Furthermore, PD98059 (ERK1/2 inhibitor) significantly enhanced 2-hydroxy-3-methylanthraquinone-induced apoptosis in U937 cells, whereas caspase-3 inhibitor or SB203580 (p-p38MAPK inhibitor), decreased apoptosis in U937 cells.	2-hydroxy-3-methylanthraquinone	63-94	mitogen-activated protein kinase 3	Homo sapiens	22-28	
23550028-8	2013	Taken together, our study for the first time suggests that 2-hydroxy-3-methylanthraquinone is able to enhance apoptosis of U937 cells, at least in part, through activation of p-p38MAPK and downregulation of p-ERK1/2.	2-hydroxy-3-methylanthraquinone	59-90	mitogen-activated protein kinase 3	Homo sapiens	209-215