PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33049605-0	2021	Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.	Isoxazoles	33-42	nuclear receptor subfamily 1, group H, member 4	Mus musculus	48-51	
33049605-0	2021	Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.	Isoxazoles	33-42	nuclear receptor subfamily 1, group H, member 4	Mus musculus	113-116	
33049605-4	2021	Our efforts focusing on isoxazole-type FXR agonists, common nonsteroidal agonists for FXR, led to the discovery a series of novel FXR agonists bearing aryl urea moieties through structural simplification of LJN452 (phase 2).	Isoxazoles	24-33	nuclear receptor subfamily 1, group H, member 4	Mus musculus	39-42	
33049605-4	2021	Our efforts focusing on isoxazole-type FXR agonists, common nonsteroidal agonists for FXR, led to the discovery a series of novel FXR agonists bearing aryl urea moieties through structural simplification of LJN452 (phase 2).	Isoxazoles	24-33	nuclear receptor subfamily 1, group H, member 4	Mus musculus	86-89	
33049605-4	2021	Our efforts focusing on isoxazole-type FXR agonists, common nonsteroidal agonists for FXR, led to the discovery a series of novel FXR agonists bearing aryl urea moieties through structural simplification of LJN452 (phase 2).	Isoxazoles	24-33	nuclear receptor subfamily 1, group H, member 4	Mus musculus	86-89	
32616182-3	2020	Some of FXR agonists possessing isoxazole moiety are undergoing clinical trials for the treatment of non-alcoholic steatohepatitis.	Isoxazoles	32-41	nuclear receptor subfamily 1, group H, member 4	Mus musculus	8-11	
32616182-5	2020	We have identified a series of nonsteroidal FXR agonists bearing N1-methyl benzimidazole and isoxazole moieties that are bridged with aromatic derivatives.	Isoxazoles	93-102	nuclear receptor subfamily 1, group H, member 4	Mus musculus	44-47	
30996771-0	2019	Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury.	Isoxazoles	6-15	nuclear receptor subfamily 1, group H, member 4	Mus musculus	40-43	
31744088-3	2019	In this study, we synthesized novel FXR agonists 1-4 possessing isoxazole and N-substituted benzimidazole moieties, and compared their effects on osteoblast differentiation with the known FXR agonists, chenodeoxycholic acid and a synthetic compound, GW4064.	Isoxazoles	64-73	nuclear receptor subfamily 1, group H, member 4	Mus musculus	36-39	
30996771-3	2019	In this Letter, we have elaborated on the structure of GW4064, the first nonsteroidal agonist for FXR, to identify novel isoxazoles endowed with FXR agonistic activity and improved ADME properties.	Isoxazoles	121-131	nuclear receptor subfamily 1, group H, member 4	Mus musculus	98-101	
30996771-3	2019	In this Letter, we have elaborated on the structure of GW4064, the first nonsteroidal agonist for FXR, to identify novel isoxazoles endowed with FXR agonistic activity and improved ADME properties.	Isoxazoles	121-131	nuclear receptor subfamily 1, group H, member 4	Mus musculus	145-148