PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21616062-7	2011	Strychnine and icajine bind to the Na(v)1.5 channel with a new mechanism that is different from TTX and local anesthetics.	Tetrodotoxin	96-99	immunoglobulin lambda variable 2-18	Homo sapiens	35-43	
22802584-8	2012	Accordingly, half of the current was blocked by 1 mum of tetrodotoxin and immunocytochemistry experiments reveal the presence of Na(v)1.5 proteins.	Tetrodotoxin	57-69	immunoglobulin lambda variable 2-18	Homo sapiens	129-137	
17935523-1	2007	AIM: Sodium current (I(Na)) of the mammalian heart is resistant to tetrodotoxin (TTX) due to low TTX affinity of the cardiac sodium channel (Na(v)) isoform Na(v)1.5.	Tetrodotoxin	81-84	immunoglobulin lambda variable 2-18	Homo sapiens	156-164	
20398673-2	2010	The tetrodotoxin (TTX) resistant isoform Na(v)1.5, encoded by the SCN5A gene, is the predominant isoform in the heart.	Tetrodotoxin	4-16	immunoglobulin lambda variable 2-18	Homo sapiens	41-49	
20398673-2	2010	The tetrodotoxin (TTX) resistant isoform Na(v)1.5, encoded by the SCN5A gene, is the predominant isoform in the heart.	Tetrodotoxin	18-21	immunoglobulin lambda variable 2-18	Homo sapiens	41-49	
19164297-1	2009	The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M. (2004) Br.	Tetrodotoxin	58-70	immunoglobulin lambda variable 2-18	Homo sapiens	128-136	
19164297-1	2009	The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M. (2004) Br.	Tetrodotoxin	72-75	immunoglobulin lambda variable 2-18	Homo sapiens	128-136	
21419143-8	2011	The latter was largely accounted for by the alteration in the TTX-binding site (Tyr401 in rNa(V)1.4, Cys for Na(V)1.5, and Ser for Na(V)1.8).	Tetrodotoxin	62-65	immunoglobulin lambda variable 2-18	Homo sapiens	109-117	
20411124-2	2010	Three of them, namely Na(v)1.5, Na(v)1.8, and Na(v)1.9, are resistant to nanomolar concentrations of tetrodotoxin (TTX; IC(50) > or = 1 microM).	Tetrodotoxin	101-113	immunoglobulin lambda variable 2-18	Homo sapiens	22-30	
20411124-2	2010	Three of them, namely Na(v)1.5, Na(v)1.8, and Na(v)1.9, are resistant to nanomolar concentrations of tetrodotoxin (TTX; IC(50) > or = 1 microM).	Tetrodotoxin	115-118	immunoglobulin lambda variable 2-18	Homo sapiens	22-30	
19698999-5	2009	Relatively weak inhibition by TTX (30+/-3% at 500nM) and sensitivity to 100microM Zn(2+) suggested that this current was predominantly mediated by the cardiac sodium channel isoform Na(V)1.5.	Tetrodotoxin	30-33	immunoglobulin lambda variable 2-18	Homo sapiens	174-190	
17935523-7	2007	More surprisingly, omNa(v)1.5a also has an aromatic tyrosine in this position, instead of the cysteine of the mammalian TTX-resistant Na(v)1.5.	Tetrodotoxin	120-123	immunoglobulin lambda variable 2-18	Homo sapiens	21-29	
15981012-5	2005	Tetrodotoxin sensitivity is largely determined by the identity of a single residue; tyrosine 401 in Na(v)1.4, cysteine 374 in Na(v)1.5 and serine 356 and 355 in Na(v)1.8 and Na(v)1.9.	Tetrodotoxin	0-12	immunoglobulin lambda variable 2-18	Homo sapiens	126-134	
15790762-3	2005	In humans, a tetrodotoxin-resistant Na+ current (Na(V)1.5) encoded by SCN5A contributes to the rising phase of the slow wave, whereas T-type Ca2+ currents have been reported from cultured mouse intestine ICC and also from canine colonic ICC.	Tetrodotoxin	13-25	immunoglobulin lambda variable 2-18	Homo sapiens	49-57	
15225632-3	2004	Semi-quantitative PCR analysis revealed that mRNAs for the alpha-subunits of multiple voltage-gated sodium channel subtypes were present but indicated that Na(v)1.5 was the predominant subtype, consistent with the TTX-resistant nature of the recorded currents.	Tetrodotoxin	214-217	immunoglobulin lambda variable 2-18	Homo sapiens	156-164