PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34209843-1 2021 In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2H-benzo(d)imidazole-2-one substructure present in HS203873, a recently identified NLRP3 binder. acrylic acid 168-180 NLR family pyrin domain containing 3 Homo sapiens 56-61 33508701-1 2021 INF39 is a nontoxic, irreversible, acrylate-based NLRP3 inhibitor and a further optimization of ethyl 2-((2-chlorophenyl) hydroxyl) methyl) acrylate (INF4E). acrylic acid 35-43 NLR family pyrin domain containing 3 Homo sapiens 50-55