PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17190832-6	2007	AtICS1 acts as a monofunctional isochorismate synthase (ICS), catalyzing the conversion of chorismate to isochorismate (IC) in a reaction that operates near equilibrium (K(eq) = 0.89).	Chorismic Acid	35-45	ADC synthase superfamily protein	Arabidopsis thaliana	0-6	
18451262-2	2008	In Arabidopsis (Arabidopsis thaliana), this compound was proposed to derive mainly from isochorismate, itself produced from chorismate through the activity of ISOCHORISMATE SYNTHASE1 (ICS1).	Chorismic Acid	91-101	ADC synthase superfamily protein	Arabidopsis thaliana	159-182	
18451262-2	2008	In Arabidopsis (Arabidopsis thaliana), this compound was proposed to derive mainly from isochorismate, itself produced from chorismate through the activity of ISOCHORISMATE SYNTHASE1 (ICS1).	Chorismic Acid	91-101	ADC synthase superfamily protein	Arabidopsis thaliana	184-188	
17190832-8	2007	Using an irreversible coupled spectrophotometric assay, we found that AtICS1 exhibits an apparent K(m) of 41.5 mum and k(cat) = 38.7 min(-1) for chorismate.	Chorismic Acid	145-155	ADC synthase superfamily protein	Arabidopsis thaliana	70-76	
30336330-2	2018	In Arabidopsis, SA is synthesized from chorismate in the chloroplast through the ICS1 (isochorismate synthase I) pathway during pathogen infection.	Chorismic Acid	39-49	ADC synthase superfamily protein	Arabidopsis thaliana	81-85	
11734859-7	2001	Here we show, by cloning and characterizing an Arabidopsis defence-related gene (SID2) defined by mutation, that SA is synthesized from chorismate by means of ICS, and that SA made by this pathway is required for LAR and SAR responses.	Chorismic Acid	136-146	ADC synthase superfamily protein	Arabidopsis thaliana	81-85	
21595875-3	2011	An important step in SA biosynthesis in Arabidopsis is the conversion of chorismate to isochorismate through the action of isochorismate synthase, encoded by the ICS1 gene.	Chorismic Acid	73-83	ADC synthase superfamily protein	Arabidopsis thaliana	162-166	
29438088-3	2018	In the first step of the pathway, the enzyme ISOCHORISMATE SYNTHASE1 (ICS1) converts chorismate to isochorismate.	Chorismic Acid	85-95	ADC synthase superfamily protein	Arabidopsis thaliana	70-74	
28356402-2	2017	A key enzyme for SA biosynthesis is isochorismate synthase (ICS), which converts chorismate into isochorismate, and for which there are two genes in Arabidopsis thaliana One (AtICS1) has been shown to be required for increased SA biosynthesis in response to pathogens and its expression can be stimulated throughout the leaf by virus infection and exogenous SA.	Chorismic Acid	39-49	ADC synthase superfamily protein	Arabidopsis thaliana	175-181	
23757404-2	2013	SA is synthesized in chloroplasts from chorismic acid by an isochorismate synthase (ICS1); SA biosynthesis is negatively regulated by autoinhibitory feedback at ICS1.	Chorismic Acid	39-53	ADC synthase superfamily protein	Arabidopsis thaliana	84-88