PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6757009-2 1982 The gliclazide-induced increase in 45Ca efflux is thought to reflect a stimulation of 40Ca influx into islet cells; it is suppressed in the absence of extracellular Ca2+ or in the presence of the organic CA2/-antagonist verapamil. Verapamil 220-229 carbonic anhydrase 2 Rattus norvegicus 204-207 6277201-5 1982 Because the increase in 45Ca efflux evoked by glucose or K+ reflects a stimulation of Ca2+ entry into islet cells, it is proposed that the B cell may be equipped with two populations of Ca2+ channels that differ in their sensitivity towards verapamil and possibly their voltage-dependency. Verapamil 241-250 carbonic anhydrase 2 Rattus norvegicus 186-189 225163-5 1979 3) Verapamil markedly inhibited either corticoidogenesis or Ca2+-influx in response to ACTH. Verapamil 3-12 carbonic anhydrase 2 Rattus norvegicus 60-63 9007031-8 1997 Analysis of the different mechanisms governing the increase in [Ca2+li using dantrolene, verapamil, and Ca2+-free medium revealed distinct differences between the two isomers with regard to the Ca2+ pools affected. Verapamil 89-98 carbonic anhydrase 2 Rattus norvegicus 64-67 16996495-0 2006 Verapamil-sensitive Ca2+ channel regulation of Th1-type proliferation of splenic lymphocytes induced by Walker 256 tumor development in rats. Verapamil 0-9 carbonic anhydrase 2 Rattus norvegicus 20-23 16996495-1 2006 Recently, we demonstrated that verapamil, an L-type Ca2+ channel blocker, inhibits the activation of splenic lymphocytes during Walker 256 ascitic tumor development in adult rats. Verapamil 31-40 carbonic anhydrase 2 Rattus norvegicus 52-55 7682512-0 1993 Effects of felodipine, nifedipine and verapamil on cytosolic Ca2+ and contraction in vascular smooth muscle. Verapamil 38-47 carbonic anhydrase 2 Rattus norvegicus 61-64 8572177-3 1995 This influx was resistant to verapamil, a selective inhibitor of L-type voltage-gated Ca2+ channels, but was sensitive to SKF-96365, an inhibitor of the receptor-operated Ca2+ entry pathway. Verapamil 29-38 carbonic anhydrase 2 Rattus norvegicus 86-89 8572177-3 1995 This influx was resistant to verapamil, a selective inhibitor of L-type voltage-gated Ca2+ channels, but was sensitive to SKF-96365, an inhibitor of the receptor-operated Ca2+ entry pathway. Verapamil 29-38 carbonic anhydrase 2 Rattus norvegicus 171-174 7918687-4 1994 Treatment of beta-cells with alloxan and H2O2 caused elevation of cytosolic free Ca2+, and this increase of Ca2+ was also abolished by verapamil. Verapamil 135-144 carbonic anhydrase 2 Rattus norvegicus 81-84 7918687-4 1994 Treatment of beta-cells with alloxan and H2O2 caused elevation of cytosolic free Ca2+, and this increase of Ca2+ was also abolished by verapamil. Verapamil 135-144 carbonic anhydrase 2 Rattus norvegicus 108-111 7682512-8 1993 These results suggest that felodipine, nifedipine and verapamil inhibit smooth muscle contraction by inhibiting Ca2+ channels at concentrations which do not change Ca2+ release or Ca2+ sensitivity of contractile elements. Verapamil 54-63 carbonic anhydrase 2 Rattus norvegicus 112-115 1838013-4 1991 The study presented here examined the effect of CRF with and without (CRF-PTX) excess PTH and the treatment of CRF rats with verapamil (V) on the Vmax and Km for calcium of synaptosomal Ca2+ ATPase, an enzyme that plays an important role in pumping calcium out of the synaptosomes. Verapamil 125-134 carbonic anhydrase 2 Rattus norvegicus 186-197 1422448-0 1992 [The interaction of the Ca2(+)-channel blocker verapamil with cardiac glycosides in the rat kidney]. Verapamil 47-56 carbonic anhydrase 2 Rattus norvegicus 24-27 3049099-8 1988 In rats, the Ca2+ antagonist verapamil not only prevented arterial calcinosis due to overdoses of vitamin D and dihydrotachysterol but also counteracted age-dependent Ca2+ accumulation. Verapamil 29-38 carbonic anhydrase 2 Rattus norvegicus 13-16 1775187-3 1991 It was demonstrated that the angiotensin II-induced increase in slowly exchanging 45Ca2+ in rat aorta was incompletely (by approximately 60%-70%) inhibited by the organic Ca2+ entry blockers nifedipine, verapamil and diltiazem and by other Ca2+ entry blocking compounds like CoCl2 and chlorpromazine. Verapamil 203-212 carbonic anhydrase 2 Rattus norvegicus 84-87 1775187-3 1991 It was demonstrated that the angiotensin II-induced increase in slowly exchanging 45Ca2+ in rat aorta was incompletely (by approximately 60%-70%) inhibited by the organic Ca2+ entry blockers nifedipine, verapamil and diltiazem and by other Ca2+ entry blocking compounds like CoCl2 and chlorpromazine. Verapamil 203-212 carbonic anhydrase 2 Rattus norvegicus 171-174 2764137-9 1989 In addition, verapamil and diltiazem seem to inhibit the release of Ca2+ from intracellular store sites, only at high concentrations, and probably by competing with histamine for binding to the H1-receptor. Verapamil 13-22 carbonic anhydrase 2 Rattus norvegicus 68-71 2172005-3 1990 The Ca2+ channel blockers D600 and verapamil reversed the suppressive effects of hypoxia. Verapamil 35-44 carbonic anhydrase 2 Rattus norvegicus 4-7 2764137-6 1989 Only at high concentrations did verapamil (IC50 = 8.7 microM) and diltiazem (IC50 = 95.7 microM) inhibit the Ca2+ release from the cellular store sites, as induced by 10 microM histamine. Verapamil 32-41 carbonic anhydrase 2 Rattus norvegicus 109-112 2764137-8 1989 From these results, we conclude that verapamil and diltiazem strongly inhibit the histamine-mediated, extracellular Ca2+-dependent intracellular [Ca2+] increase. Verapamil 37-46 carbonic anhydrase 2 Rattus norvegicus 116-119 2764137-8 1989 From these results, we conclude that verapamil and diltiazem strongly inhibit the histamine-mediated, extracellular Ca2+-dependent intracellular [Ca2+] increase. Verapamil 37-46 carbonic anhydrase 2 Rattus norvegicus 146-149 2468939-6 1989 The effect of verapamil and inactivity of flunarizine on the spontaneous arteriolar vasomotion may result from an interference by the former drug with the myogenic activity of vascular smooth muscle cells, caused by Ca2+ translocations in physiologic conditions and the lack of such an interference by the latter compound. Verapamil 14-23 carbonic anhydrase 2 Rattus norvegicus 216-219 2468939-7 1989 These observations performed on the same blood vessels corroborate the differentiation between Ca2+ slow channel blockers (verapamil) and Ca2+ overload blockers (flunarizine) in vivo. Verapamil 123-132 carbonic anhydrase 2 Rattus norvegicus 95-98 3383374-1 1988 We investigated the effects of the Ca2+ antagonists diltiazem and verapamil on release of Ca2+ from intracellular store sites of rat aorta vascular smooth muscle cells in primary culture. Verapamil 66-75 carbonic anhydrase 2 Rattus norvegicus 90-93 3383374-3 1988 In the presence of 1 mM extracellular Ca2+, both diltiazem (IC50, 0.31 microM) and verapamil (IC50, 0.47 microM) dose-dependently inhibited elevations in the cytosolic Ca2+, as induced by depolarization of the plasma membrane with high extracellular K+. Verapamil 83-92 carbonic anhydrase 2 Rattus norvegicus 38-41 3383374-3 1988 In the presence of 1 mM extracellular Ca2+, both diltiazem (IC50, 0.31 microM) and verapamil (IC50, 0.47 microM) dose-dependently inhibited elevations in the cytosolic Ca2+, as induced by depolarization of the plasma membrane with high extracellular K+. Verapamil 83-92 carbonic anhydrase 2 Rattus norvegicus 168-171 3049099-8 1988 In rats, the Ca2+ antagonist verapamil not only prevented arterial calcinosis due to overdoses of vitamin D and dihydrotachysterol but also counteracted age-dependent Ca2+ accumulation. Verapamil 29-38 carbonic anhydrase 2 Rattus norvegicus 167-170 3049099-9 1988 Spontaneously hypertensive rats also exhibit progressive arterial Ca2+ overload which responds excellently to the Ca2+ antagonists nifedipine, nimodipine, nisoldipine, nitrendipine, as well as to verapamil and diltiazem. Verapamil 196-205 carbonic anhydrase 2 Rattus norvegicus 66-69 2441812-6 1987 verapamil (50-100 microM) and fendiline (100-200 microM) reduced the postsynaptic influx of Ca2+ but did not alter Ca2+ loss from the extracellular space into presynaptic terminals. Verapamil 0-9 carbonic anhydrase 2 Rattus norvegicus 92-95 2427806-1 1986 Ethanol and verapamil are both known to affect the transmembrane movement of Ca2+ in several biological systems. Verapamil 12-21 carbonic anhydrase 2 Rattus norvegicus 77-80 2427806-7 1986 It is hypothesized that the ethanol-verapamil interaction is mediated through a reduction in transmembrane Ca2+ movement. Verapamil 36-45 carbonic anhydrase 2 Rattus norvegicus 107-110