PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35078445-12 2022 In vitro, we further confirmed that curcumin significantly downregulated the expression of AURKA, CDK1, and TOP2A genes, while significantly upregulated the expression of CYP2B6, CYP2C9, and CYP3A4 genes. Curcumin 36-44 cyclin dependent kinase 1 Homo sapiens 98-102 35078445-13 2022 CONCLUSIONS: Our results provided a novel panel of AURKA, CDK1, TOP2A, CYP2C9, and CYP3A4 candidate genes for curcumin related chemotherapy of hepatocellular carcinoma. Curcumin 110-118 cyclin dependent kinase 1 Homo sapiens 58-62 26442630-7 2016 Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation. Curcumin 37-45 cyclin dependent kinase 1 Homo sapiens 106-110 32337261-5 2020 Results: Curcumin was found to suppress the proliferation of LECs by inducing G2/M arrest via possible inhibition of cell cycle-related proteins including CDK1, cyclin B1, and CDC25C. Curcumin 9-17 cyclin dependent kinase 1 Homo sapiens 155-159 30116377-5 2018 In-depth study of its mechanism of action revealed that curcumin induced cell cycle arrest at the G2/M phase and decreased the expression of the CDC25 and CDC2 proteins, while increasing the expression of P21. Curcumin 56-64 cyclin dependent kinase 1 Homo sapiens 145-149 30116377-7 2018 In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway. Curcumin 15-23 cyclin dependent kinase 1 Homo sapiens 176-180 27035875-4 2016 By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1). Curcumin 116-124 cyclin dependent kinase 1 Homo sapiens 305-330 27035875-4 2016 By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1). Curcumin 116-124 cyclin dependent kinase 1 Homo sapiens 332-336 27035875-7 2016 Furthermore, following knockdown of FoxO1 expression in curcumin-treated U87 cells using FoxO1 small interfering RNA, the expression levels of cyclin G2, cleaved caspase-3 and FasL were inhibited; however, the expression levels of CDK1 were not markedly altered. Curcumin 56-64 cyclin dependent kinase 1 Homo sapiens 231-235 26796279-7 2016 The results indicated that curcumin induced cell cycle arrest at G2/M phase by downregulation of cyclin B1 and Cdc2 and inhibited colony formation in MCF-7wt cells. Curcumin 27-35 cyclin dependent kinase 1 Homo sapiens 111-115 26442630-9 2016 These results collectively show that curcumin treatment induced the DNA damage response via triggering an ATM-activated Chk2-Cdc25C-Cdc2 signaling pathway. Curcumin 37-45 cyclin dependent kinase 1 Homo sapiens 125-129 23848205-9 2013 Since curcumin is known to inhibit the cyclin D1-dependent G1/S-phase kinase CDK4 and the cyclin B-dependent G2/M-phase kinase CDK1 that catalyze phosphorylation-mediated inactivation of Rb, our results indicate that SunC containing a lower dose of sunitinib would be effective in restoring the tumor suppressor activity of Rb, thereby truncating cell cycle and triggering cell death. Curcumin 6-14 cyclin dependent kinase 1 Homo sapiens 127-131 21887696-4 2011 Treatment of SCC-4 cells with curcumin caused a moderate and promoted the G(2) /M phase arrest, which was accompanied with decreases in cyclin B/CDK1 and CDC25C protein levels. Curcumin 30-38 cyclin dependent kinase 1 Homo sapiens 145-149 23351311-6 2012 The inhibition of cdk1 phosphorylation is one of alternative strategy which could selectively kill cancer cells and potentially be combined with DNA damaging agent such as curcumin. Curcumin 172-180 cyclin dependent kinase 1 Homo sapiens 18-22 21617861-5 2011 The results indicated that curcumin-induced G2/M phase arrest was associated with a marked decrease in the protein expression of cyclin A, cyclin B and cyclin-dependent kinase 1 (Cdk1). Curcumin 27-35 cyclin dependent kinase 1 Homo sapiens 152-177 21617861-5 2011 The results indicated that curcumin-induced G2/M phase arrest was associated with a marked decrease in the protein expression of cyclin A, cyclin B and cyclin-dependent kinase 1 (Cdk1). Curcumin 27-35 cyclin dependent kinase 1 Homo sapiens 179-183 21857083-8 2011 In addition, curcumin significantly decreased p38MAPK and phospho-CDC-2 protein expression and increased phospho-p38MAPK, p42/44MAPK, and phospho-p42/44MAPK protein expression. Curcumin 13-21 cyclin dependent kinase 1 Homo sapiens 66-71 20596601-10 2010 In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB. Curcumin 48-56 cyclin dependent kinase 1 Homo sapiens 146-150 20878089-13 2010 Curcumin induced cell cycle arrest at the G2/M phase by decreasing the Cdc2 expression. Curcumin 0-8 cyclin dependent kinase 1 Homo sapiens 71-75 19401701-8 2009 Concomitant decrease in the expressions of cyclin B1 and Cdk1 were seen in curcumin-treated cells. Curcumin 75-83 cyclin dependent kinase 1 Homo sapiens 57-61 12118335-3 2002 Curcumin was found to induce G0/G1 and/or G2/M phase cell cycle arrest, up-regulate CDKIs, p21WAF1/CIP1, p27KIP1, and p53, and slightly down-regulate cyclin B1 and cdc2 in ECV304 cells. Curcumin 0-8 cyclin dependent kinase 1 Homo sapiens 164-168 16106398-5 2006 Curcumin induced cell cycle arrest by reducing the expression of cyclin D1, Cdk1 and Cdc25C and apoptosis by reducing the expression of XIAP and survivin. Curcumin 0-8 cyclin dependent kinase 1 Homo sapiens 76-80 17148446-8 2007 In addition, curcumin treatment reduces cell number, which is associated with a reduced cyclin and cdk1 levels. Curcumin 13-21 cyclin dependent kinase 1 Homo sapiens 99-103 17569210-6 2007 Curcumin arrested the cell cycle by preventing the expression of cyclin D1, cdk-1 and cdc-25. Curcumin 0-8 cyclin dependent kinase 1 Homo sapiens 76-81 31394642-6 2006 Futhermore, curcumin induced Wee1 expression and decreased the Cdc25c, cyclin B1 and CDK1 expressions, resulting in the induction of G2/M cell cycle arrest in the colo 205 cells. Curcumin 12-20 cyclin dependent kinase 1 Homo sapiens 85-89 31394642-8 2006 CONCLUSION: The results indicate that curcumin promoted the gene expression of Wee1 and inhibited that of Cdc25c, CDK1 and cyclin B1. Curcumin 38-46 cyclin dependent kinase 1 Homo sapiens 114-118 14534529-4 2003 The amount of wee1 and c-Fos and the phosphorylation of cdc2 were decreased after treatment of the cells with an inhibitor of AP-1, curcumin. Curcumin 132-140 cyclin dependent kinase 1 Homo sapiens 56-60 34134960-6 2021 The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05). Curcumin 44-52 cyclin dependent kinase 1 Homo sapiens 200-204 11396178-4 2001 Investigation of cyclin-dependent kinases, Cdk2 and Cdc2, showed activity of Cdc2, but not Cdk2, increased markedly in response to curcumin. Curcumin 131-139 cyclin dependent kinase 1 Homo sapiens 52-56 11396178-4 2001 Investigation of cyclin-dependent kinases, Cdk2 and Cdc2, showed activity of Cdc2, but not Cdk2, increased markedly in response to curcumin. Curcumin 131-139 cyclin dependent kinase 1 Homo sapiens 77-81