PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22523587-0	2012	Curcumin attenuates beta-catenin signaling in prostate cancer cells through activation of protein kinase D1.	Curcumin	0-8	protein kinase D1	Mus musculus	90-107	
22523587-7	2012	Herein, we have demonstrated that curcumin activates PKD1, resulting in changes in beta-catenin signaling by inhibiting nuclear beta-catenin transcription activity and enhancing the levels of membrane beta-catenin in prostate cancer cells.	Curcumin	34-42	protein kinase D1	Mus musculus	53-57	
22523587-9	2012	In addition, we have also revealed that inhibition of cell motility by curcumin is mediated by decreasing the levels of active cofilin, a downstream target of PKD1.	Curcumin	71-79	protein kinase D1	Mus musculus	159-163	
22523587-12	2012	Overall, our findings herein have revealed a novel molecular mechanism of curcumin action via the activation of PKD1 in prostate cancer cells.	Curcumin	74-82	protein kinase D1	Mus musculus	112-116