PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33178666-3 2020 Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 54-58 33246423-9 2020 Concomitant with apoptotic induction, epidermal growth factor receptor (EGFR) activation was observed upon curcumin treatment, which was further activated in I227T/N236D mutant transfectant cells when compared with wild-type cells. Curcumin 107-115 epidermal growth factor receptor Homo sapiens 38-70 33246423-9 2020 Concomitant with apoptotic induction, epidermal growth factor receptor (EGFR) activation was observed upon curcumin treatment, which was further activated in I227T/N236D mutant transfectant cells when compared with wild-type cells. Curcumin 107-115 epidermal growth factor receptor Homo sapiens 72-76 32691972-5 2020 Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2. Curcumin 70-78 epidermal growth factor receptor Homo sapiens 270-274 31793078-7 2020 The results showed that curcumin could regulate the circRNA-miRNA-messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor-bound protein 2 (GRB2) to achieve radiosensitization. Curcumin 24-32 epidermal growth factor receptor Homo sapiens 104-136 31545905-12 2020 Incubation with curcumin and quercetin decreased the EGFR levels. Curcumin 16-24 epidermal growth factor receptor Homo sapiens 53-57 31793078-7 2020 The results showed that curcumin could regulate the circRNA-miRNA-messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor-bound protein 2 (GRB2) to achieve radiosensitization. Curcumin 24-32 epidermal growth factor receptor Homo sapiens 138-142 29620257-0 2018 Curcumin suppresses MUC5AC production via interfering with the EGFR signaling pathway. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 63-67 31432177-0 2019 Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 111-115 31432177-7 2019 Furthermore, curcumin significantly inhibited the expression of Toll-like receptor 4 (TLR4)/MyD88 and EGFR in a dose- and time-dependent manner. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 102-106 31432177-10 2019 These data suggested that curcumin may control the EGFR and TLR4/MyD88 pathways to synergistically downregulate downstream cell cycle- and EMT-related regulators, in order to block cell proliferation and metastasis in NSCLC. Curcumin 26-34 epidermal growth factor receptor Homo sapiens 51-55 31289524-10 2019 Furthermore, the radiosensitization effects of curcumin and cisplatin on NSCLC A549 cells, which include inhibition of proliferation, migration and invasion, may be associated with the inhibition of the EGFR-associated signaling pathway. Curcumin 47-55 epidermal growth factor receptor Homo sapiens 203-207 30899155-0 2019 Molecular designing, virtual screening and docking study of novel curcumin analogue as mutation (S769L and K846R) selective inhibitor for EGFR. Curcumin 66-74 epidermal growth factor receptor Homo sapiens 138-142 30542713-5 2019 As high glucose is able to induce the expression of epidermal growth factor (EGF), which is intimately related with tumor progression, the aim of this study was to evaluate whether curcumin could influence the high glucose-induced EGF/EGFR pathway and the biological activity of pancreatic cancer cells. Curcumin 181-189 epidermal growth factor receptor Homo sapiens 235-239 30542713-13 2019 In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin. Curcumin 126-134 epidermal growth factor receptor Homo sapiens 41-45 30542713-14 2019 Taken together, the present study indicates that curcumin suppresses hyperglycemia-driven EGF-induced invasion and migration of pancreatic cancer cells by inhibiting the EGF/EGFR signaling pathway and its downstream signaling molecules including ERK and Akt. Curcumin 49-57 epidermal growth factor receptor Homo sapiens 174-178 29157028-0 2018 Enhanced selective cellular uptake and cytotoxicity of epidermal growth factor-conjugated liposomes containing curcumin on EGFR-overexpressed pancreatic cancer cells. Curcumin 111-119 epidermal growth factor receptor Homo sapiens 123-127 29157028-6 2018 It is also shown that the cellular uptake of curcumin on BxPC-3, which is essential for the cytotoxicity, is associated with EGFR-mediated mechanism of action. Curcumin 45-53 epidermal growth factor receptor Homo sapiens 125-129 29157028-7 2018 In summary, our results have showed that targeting EGFR with EGF-conjugated curcumin liposomes enhanced the antitumor activity of curcumin against human pancreatic cancer cells. Curcumin 76-84 epidermal growth factor receptor Homo sapiens 51-55 29157028-7 2018 In summary, our results have showed that targeting EGFR with EGF-conjugated curcumin liposomes enhanced the antitumor activity of curcumin against human pancreatic cancer cells. Curcumin 130-138 epidermal growth factor receptor Homo sapiens 51-55 30214301-0 2018 A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction. Curcumin 26-34 epidermal growth factor receptor Homo sapiens 71-75 31196210-8 2019 Combination treatment with curcumin and gefitinib markedly downregulated EGFR activity through suppressing Sp1 and blocking interaction of Sp1 and HADC1, and markedly suppressed receptor tyrosine kinases as well as ERK/MEK and AKT/S6K pathways in the resistant NSCLC cells. Curcumin 27-35 epidermal growth factor receptor Homo sapiens 73-77 31196210-12 2019 Curcumin can be used as a sensitizer to enhance the efficacy of EGFR-TKIs and overcome the EGFR-TKI resistance in NSCLC patients with wild-type EGFR and/or KRAS mutation. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 64-68 31196210-12 2019 Curcumin can be used as a sensitizer to enhance the efficacy of EGFR-TKIs and overcome the EGFR-TKI resistance in NSCLC patients with wild-type EGFR and/or KRAS mutation. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 91-95 31196210-12 2019 Curcumin can be used as a sensitizer to enhance the efficacy of EGFR-TKIs and overcome the EGFR-TKI resistance in NSCLC patients with wild-type EGFR and/or KRAS mutation. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 91-95 30333889-9 2018 The results demonstrated that co-treatment with cetuximab and curcumin exerts synergistic oral anticancer effects on CAR cells through the suppression of the EGFR signaling by regulation of the MAPK pathway. Curcumin 62-70 epidermal growth factor receptor Homo sapiens 158-162 29620257-5 2018 In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 73-85 29620257-5 2018 In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 87-91 29620257-7 2018 In addition, treatment with curcumin significantly decreased MUC5AC and EGFR expression in a time-dependent manner under basal conditions. Curcumin 28-36 epidermal growth factor receptor Homo sapiens 72-76 29620257-9 2018 This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells. Curcumin 136-144 epidermal growth factor receptor Homo sapiens 63-67 29620257-9 2018 This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells. Curcumin 136-144 epidermal growth factor receptor Homo sapiens 98-102 29620257-9 2018 This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells. Curcumin 136-144 epidermal growth factor receptor Homo sapiens 98-102 29805641-10 2018 These results indicate that EGF-conjugated NHS-PEG10000-DSPE phospholipid NPs loaded with curcumin may be useful for treating TNBCs that overexpress the EGF receptor. Curcumin 90-98 epidermal growth factor receptor Homo sapiens 153-165 28117012-0 2017 Current Status and Perspectives Regarding the Therapeutic Potential of Targeting EGFR Pathway by Curcumin in Lung Cancer. Curcumin 97-105 epidermal growth factor receptor Homo sapiens 81-85 29700289-3 2018 In the present study, we demonstrated that FAK is implicated in RCP-induced EGFR phosphorylation and ovarian cancer cell invasion with inhibition by curcumin. Curcumin 149-157 epidermal growth factor receptor Homo sapiens 76-80 29700289-5 2018 Interestingly, we observed for the first time that curcumin attenuates RCP-induced ovarian cancer cell invasion by blocking stabilization of beta1 integrin and consequently inhibiting FAK and EGFR activation, providing potential biomarkers for ovarian cancer and therapeutic approaches for this deadly disease. Curcumin 51-59 epidermal growth factor receptor Homo sapiens 192-196 29445279-0 2018 EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles. Curcumin 38-46 epidermal growth factor receptor Homo sapiens 0-4 29445279-8 2018 Conclusion: These curcumin-encapsulated chitosan/TPP nanoparticles are a promising targeted-PDT against EGFR-overexpressing cancers. Curcumin 18-26 epidermal growth factor receptor Homo sapiens 104-108 29052674-4 2017 Here, we demonstrate that epidermal growth factor receptor (EGFR)-targeting GE11 peptides conjugated with PEGylated polylactic-co-glycolic acid (PLGA) nanoparticles can be used to effectively deliver an anti-cancer agent, curcumin, into EGFR-expressing MCF-7 cells in vitro and in vivo. Curcumin 222-230 epidermal growth factor receptor Homo sapiens 26-58 29052674-4 2017 Here, we demonstrate that epidermal growth factor receptor (EGFR)-targeting GE11 peptides conjugated with PEGylated polylactic-co-glycolic acid (PLGA) nanoparticles can be used to effectively deliver an anti-cancer agent, curcumin, into EGFR-expressing MCF-7 cells in vitro and in vivo. Curcumin 222-230 epidermal growth factor receptor Homo sapiens 60-64 28122302-2 2017 In this report, we designed EGFR peptide decorated nanoparticles (NPs) to co-deliver docetaxel (DTX) and pH sensitive curcumin (CUR) prodrug for the treatment of prostate cancer. Curcumin 118-126 epidermal growth factor receptor Homo sapiens 28-32 28286519-6 2017 In this paper we aim to review the involvement of ErbB proteins in cancer as well as the biologic activity of EGCG and curcumin in ErbB expressing and overexpressing malignancies. Curcumin 119-127 epidermal growth factor receptor Homo sapiens 131-135 26468449-6 2015 We will also outline the various mechanisms of EGFR inhibition that are induced by naturally occurring chemopreventative agents such as ginseng, green tea, and curcumin. Curcumin 160-168 epidermal growth factor receptor Homo sapiens 47-51 26505786-0 2016 Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways. Curcumin 25-33 epidermal growth factor receptor Homo sapiens 131-135 26505786-9 2016 In addition, curcumin exposure along with 5-FU or DOX inhibited cell proliferation through the downregulation of EGFR-ERK1/2 signaling molecules. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 113-117 25753330-0 2015 Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects. Curcumin 6-14 epidermal growth factor receptor Homo sapiens 35-39 25753330-0 2015 Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects. Curcumin 6-14 epidermal growth factor receptor Homo sapiens 91-95 25753330-1 2015 Curcumin (1) down-regulates the expression as well as phosphorylation of epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells expressing gefitinib-resistant EGFR. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 73-105 25753330-1 2015 Curcumin (1) down-regulates the expression as well as phosphorylation of epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells expressing gefitinib-resistant EGFR. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 107-111 25753330-1 2015 Curcumin (1) down-regulates the expression as well as phosphorylation of epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells expressing gefitinib-resistant EGFR. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 173-177 25753330-6 2015 Among all evaluated curcumin derivatives, compound 2 showed the best inhibitory effects on both wild-type and mutant EGFR by efficiently inducing gefitinib-insensitive EGFR degradation. Curcumin 20-28 epidermal growth factor receptor Homo sapiens 117-121 25400722-0 2014 Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 78-82 25400722-2 2014 Curcumin is known to inhibit growth, invasion and metastasis by downregulating EGFR expression in some cancer cells. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 79-83 25400722-5 2014 We also explored the effect of curcumin on the activition of EGFR and its downstream signaling molecules Akt, ERK1/2 and STAT3. Curcumin 31-39 epidermal growth factor receptor Homo sapiens 61-65 25400722-6 2014 Furthermore, we examined the inhibition effect of curcumin on EGF-induced EGFR phosphorylation and SCC-25 cells invasion. Curcumin 50-58 epidermal growth factor receptor Homo sapiens 74-78 25400722-9 2014 We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3. Curcumin 25-33 epidermal growth factor receptor Homo sapiens 50-54 25400722-9 2014 We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3. Curcumin 25-33 epidermal growth factor receptor Homo sapiens 59-63 25400722-11 2014 Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3. Curcumin 41-49 epidermal growth factor receptor Homo sapiens 140-144 25400722-11 2014 Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3. Curcumin 41-49 epidermal growth factor receptor Homo sapiens 149-153 24491504-0 2014 Ensemble docking and molecular dynamics identify knoevenagel curcumin derivatives with potent anti-EGFR activity. Curcumin 61-69 epidermal growth factor receptor Homo sapiens 99-103 24318305-0 2014 Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling. Curcumin 39-47 epidermal growth factor receptor Homo sapiens 115-119 24318305-4 2014 In addition, simultaneous treatment with paclitaxel and curcumin strongly inhibited paclitaxel-induced activities of EGFR signaling. Curcumin 56-64 epidermal growth factor receptor Homo sapiens 117-121 24491504-3 2014 In the present study, a molecular docking and molecular dynamics investigation has been carried out with an ensemble of EGFR-TK structures against a synthetically feasible library of curcumin analogs to discover potent EGFR inhibitors. Curcumin 183-191 epidermal growth factor receptor Homo sapiens 219-223 24491504-6 2014 Finally, the 5 ns molecular dynamics simulation shows that knoevenagel condensate of curcumin specifically C29 and C30 can be used as starting blocks for developing effective leads capable of inhibiting EGFR. Curcumin 85-93 epidermal growth factor receptor Homo sapiens 203-207 24508477-9 2014 Both curcumin and EGCG effectively reduced acrylamide-induced proliferation, as well as protein expression of CYP2E1, EGFR, cyclin D1 and NF-kappaB. Curcumin 5-13 epidermal growth factor receptor Homo sapiens 118-122 24445050-0 2014 Down-regulation of epidermal growth factor receptor by curcumin-induced UBE1L in human bronchial epithelial cells. Curcumin 55-63 epidermal growth factor receptor Homo sapiens 19-51 24445050-3 2014 Curcumin, a well-studied chemopreventive agent, is known to down-regulate EGFR. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 74-78 24445050-4 2014 The present study demonstrated that curcumin decreased EGFR expression in human bronchial epithelial (HBE) Beas-2B cells and lung cancer A549 cells. Curcumin 36-44 epidermal growth factor receptor Homo sapiens 55-59 24445050-8 2014 Curcumin decreased EGFR downstream signaling pAKT and nuclear factor kappaB (NF-kappaB). Curcumin 0-8 epidermal growth factor receptor Homo sapiens 19-23 24445050-11 2014 These results uncover a novel chemopreventive mechanism of curcumin in inducing UBE1L and down-regulating EGFR signaling in HBE cells. Curcumin 59-67 epidermal growth factor receptor Homo sapiens 106-110 23234806-7 2013 RESULTS: Curcumin selectively eliminates a variety of HPV(+) cervical cancer cells (HeLa, ME-180, SiHa, and SW756), suppresses the transforming antigen E6, dramatically inhibits the expression of the pro-cancer protein epidermal growth factor receptor (EGFR), and concomitantly induces p53. Curcumin 9-17 epidermal growth factor receptor Homo sapiens 253-257 23880083-0 2013 Exploring pyrimidine-substituted curcumin analogues: design, synthesis and effects on EGFR signaling. Curcumin 33-41 epidermal growth factor receptor Homo sapiens 86-90 23880083-2 2013 Curcumin inhibits cancer cell growth in vitro by suppressing gene expression of EGFR and reduces tumor growth in various animal models. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 80-84 23245570-0 2013 Design, synthesis and molecular docking of alpha,beta-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity. Curcumin 93-101 epidermal growth factor receptor Homo sapiens 112-116 23245570-1 2013 A type of novel alpha,beta-unsaturated cyclohexanone analogous, which designed based on the curcumin core structure, have been discovered as potential EGFR inhibitors. Curcumin 92-100 epidermal growth factor receptor Homo sapiens 151-155 23194063-6 2012 Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50). Curcumin 0-8 epidermal growth factor receptor Homo sapiens 238-270 24512728-0 2013 Curcumin lowers erlotinib resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 89-101 24512728-9 2013 Furthermore, curcumin significantly increased the cytotoxicity of erlotinib to erlotinib-resistant NSCLC cells, enhanced erlotinib-induced apoptosis, downregulated the expressions of EGFR, p-EGFR, and survivin, and inhibited the NF-kappaB activation in erlotinib-resistant NSCLC cells. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 183-187 24512728-9 2013 Furthermore, curcumin significantly increased the cytotoxicity of erlotinib to erlotinib-resistant NSCLC cells, enhanced erlotinib-induced apoptosis, downregulated the expressions of EGFR, p-EGFR, and survivin, and inhibited the NF-kappaB activation in erlotinib-resistant NSCLC cells. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 191-195 23023821-0 2012 Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 95-99 23194063-6 2012 Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50). Curcumin 0-8 epidermal growth factor receptor Homo sapiens 272-276 22489192-5 2012 Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell. Curcumin 97-105 epidermal growth factor receptor Homo sapiens 114-146 22489192-5 2012 Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell. Curcumin 97-105 epidermal growth factor receptor Homo sapiens 148-152 22489192-9 2012 Therefore, EGFR-, miRNA-, autophagy- and cancer stem cell-based therapy in the presence of curcumin might be promising mechanisms and targets in the therapeutic strategy of lung cancer. Curcumin 91-99 epidermal growth factor receptor Homo sapiens 11-15 20332435-5 2010 However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1. Curcumin 22-30 epidermal growth factor receptor Homo sapiens 179-183 21567511-5 2012 The observation suggested that combined treatment of a low dosage of curcumin with inhibitors against epidermal growth factor receptor (EGFR), insulin-like growth factor 1 (IGF-1R), fibroblast growth factors receptor (FGFR), phosphatidylinositol 3-kinases (PI3K) or NF-kappaB signaling pathway may be a potential adjuvant therapy beneficial to NSCLC patients. Curcumin 69-77 epidermal growth factor receptor Homo sapiens 102-134 21567511-5 2012 The observation suggested that combined treatment of a low dosage of curcumin with inhibitors against epidermal growth factor receptor (EGFR), insulin-like growth factor 1 (IGF-1R), fibroblast growth factors receptor (FGFR), phosphatidylinositol 3-kinases (PI3K) or NF-kappaB signaling pathway may be a potential adjuvant therapy beneficial to NSCLC patients. Curcumin 69-77 epidermal growth factor receptor Homo sapiens 136-140 21859497-4 2011 The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/beta-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription (STATs). Curcumin 36-44 epidermal growth factor receptor Homo sapiens 105-109 21858220-0 2011 Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 17-21 21858220-4 2011 METHODS/PRINCIPAL FINDINGS: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR. Curcumin 87-95 epidermal growth factor receptor Homo sapiens 220-224 21858220-4 2011 METHODS/PRINCIPAL FINDINGS: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR. Curcumin 87-95 epidermal growth factor receptor Homo sapiens 259-263 21858220-4 2011 METHODS/PRINCIPAL FINDINGS: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR. Curcumin 87-95 epidermal growth factor receptor Homo sapiens 259-263 21858220-4 2011 METHODS/PRINCIPAL FINDINGS: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR. Curcumin 87-95 epidermal growth factor receptor Homo sapiens 259-263 20407012-4 2010 BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death. Curcumin 4-12 epidermal growth factor receptor Homo sapiens 232-236 20407012-4 2010 BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death. Curcumin 110-118 epidermal growth factor receptor Homo sapiens 98-102 20407012-4 2010 BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death. Curcumin 110-118 epidermal growth factor receptor Homo sapiens 232-236 20407012-5 2010 The results show that EGFR is an Sp-regulated gene in bladder cancer, and drugs such as BA and curcumin that repress Sp proteins also ablate EGFR expression. Curcumin 95-103 epidermal growth factor receptor Homo sapiens 22-26 20407012-5 2010 The results show that EGFR is an Sp-regulated gene in bladder cancer, and drugs such as BA and curcumin that repress Sp proteins also ablate EGFR expression. Curcumin 95-103 epidermal growth factor receptor Homo sapiens 141-145 20407012-6 2010 Thus, compounds such as curcumin and BA that downregulate Sp transcription factors represent a novel class of anticancer drugs that target EGFR in bladder cancer cells and tumors by inhibiting receptor expression. Curcumin 24-32 epidermal growth factor receptor Homo sapiens 139-143 18332871-6 2008 Further experiments observed that curcumin dose dependently reduced gene expression of PDGF and EGF receptors (ie, PDGF-betaR and EGFR), which required PPARgamma activation. Curcumin 34-42 epidermal growth factor receptor Homo sapiens 130-134 18214481-7 2008 We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation. Curcumin 18-26 epidermal growth factor receptor Homo sapiens 224-228 18214481-7 2008 We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation. Curcumin 154-162 epidermal growth factor receptor Homo sapiens 224-228 19956394-6 2009 Treatment of FOLFOX-surviving colon cancer cells with either curcumin alone or together with FOLFOX resulted in a marked reduction in CSCs, as evidenced by the decreased expression of CD44 and CD166 as well as EGFR and by their ability to form anchorage-dependent colonies. Curcumin 61-69 epidermal growth factor receptor Homo sapiens 210-214 19956394-8 2009 Increased expression of EGFR in FOLFOX-surviving cells could be attributed to hypomethylation of the EGFR promoter, whereas an opposite phenomenon was observed when the FOLFOX-surviving cells were treated with curcumin and/or FOLFOX. Curcumin 210-218 epidermal growth factor receptor Homo sapiens 24-28 19448398-2 2009 It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined. Curcumin 41-49 epidermal growth factor receptor Homo sapiens 75-87 19448398-2 2009 It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined. Curcumin 41-49 epidermal growth factor receptor Homo sapiens 89-93 19448398-2 2009 It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined. Curcumin 41-49 epidermal growth factor receptor Homo sapiens 196-200 18719366-7 2008 Further more, expression of EGFR and ERBB2 receptor were found to be downregulated in curcumin treated LNCaP and C4-2B cells. Curcumin 86-94 epidermal growth factor receptor Homo sapiens 28-32 18332871-8 2008 In addition, curcumin reduced the phosphorylation levels of PDGF-betaR and EGFR, as well as their downstream signaling cascades, including ERK1/2 and JNK1/2. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 75-79 18332871-10 2008 De novo synthesis of glutathione was required for curcumin to suppress pdgf-betar and egfr expression in activated HSCs. Curcumin 50-58 epidermal growth factor receptor Homo sapiens 86-90 18332871-11 2008 Our results collectively demonstrated that enhancement of PPARgamma activity by curcumin interrupted PDGF and EGF signaling in activated HSCs by reducing the phosphorylation levels of PDGF-betaR and EGFR, and by suppressing the receptor gene expression. Curcumin 80-88 epidermal growth factor receptor Homo sapiens 199-203 17569205-7 2007 Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN). Curcumin 0-8 epidermal growth factor receptor Homo sapiens 202-234 17918158-0 2008 Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 131-135 16170359-0 2006 Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 83-115 17201164-0 2006 Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. Curcumin 66-74 epidermal growth factor receptor Homo sapiens 144-148 17201164-2 2006 Other studies indicated that epidermal growth factor receptor (EGFR) is also inhibited by curcumin in vitro and in vivo. Curcumin 90-98 epidermal growth factor receptor Homo sapiens 29-61 17201164-2 2006 Other studies indicated that epidermal growth factor receptor (EGFR) is also inhibited by curcumin in vitro and in vivo. Curcumin 90-98 epidermal growth factor receptor Homo sapiens 63-67 17201164-4 2006 Our aim was to evaluate whether the curcumin inhibitory effect on the survival of cancer cells is associated with simultaneous down-regulation of COX-2 and EGFR and inhibition of Erk1/2 (extra-cellular signal regulated kinase) signaling pathway. Curcumin 36-44 epidermal growth factor receptor Homo sapiens 156-160 17201164-10 2006 In the p34 and PC-14 cells, curcumin decreased COX-2, EGFR and p-Erk1/2 expressions in a dose-dependent manner. Curcumin 28-36 epidermal growth factor receptor Homo sapiens 54-58 17201164-12 2006 CONCLUSION: Curcumin co-inhibited COX-2 and EGFR expression and decreased Erk1/2 activity. Curcumin 12-20 epidermal growth factor receptor Homo sapiens 44-48 16299382-0 2006 Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin. Curcumin 131-139 epidermal growth factor receptor Homo sapiens 14-18 16299382-8 2006 As these events can be downstream of the activation of epidermal growth factor receptor (EGFR), we pretreated PC-3 cells with PEITC and curcumin and then stimulated them with EGF. Curcumin 136-144 epidermal growth factor receptor Homo sapiens 55-87 16299382-8 2006 As these events can be downstream of the activation of epidermal growth factor receptor (EGFR), we pretreated PC-3 cells with PEITC and curcumin and then stimulated them with EGF. Curcumin 136-144 epidermal growth factor receptor Homo sapiens 89-93 16299382-9 2006 EGFR phosphorylations (Y845 and Y1068) were dramatically suppressed by PEITC or curcumin, and more so by the combination. Curcumin 80-88 epidermal growth factor receptor Homo sapiens 0-4 16299382-11 2006 We conclude that the simultaneous targeting of EGFR, Akt and NF-kappaB signaling pathways by PEITC and curcumin could be the molecular targets by which PEITC and curcumin exert their additive inhibitory effects on cell proliferation and ultimately lead to programmed cell death of tumor cells. Curcumin 103-111 epidermal growth factor receptor Homo sapiens 47-51 16299382-11 2006 We conclude that the simultaneous targeting of EGFR, Akt and NF-kappaB signaling pathways by PEITC and curcumin could be the molecular targets by which PEITC and curcumin exert their additive inhibitory effects on cell proliferation and ultimately lead to programmed cell death of tumor cells. Curcumin 162-170 epidermal growth factor receptor Homo sapiens 47-51 16170359-4 2006 We recently reported that curcumin inhibited the growth of human colon cancer-derived Moser cells by suppressing gene expression of cyclinD1 and EGFR. Curcumin 26-34 epidermal growth factor receptor Homo sapiens 145-149 16170359-5 2006 The aim of the present study was to explore the molecular mechanisms underlying curcumin inhibition of gene expression of EGFR in colon cancer cells. Curcumin 80-88 epidermal growth factor receptor Homo sapiens 122-126 16170359-6 2006 The generality of the inhibitory effect of curcumin on gene expression of EGFR was verified in other human colon cancer-derived cell lines, including Caco-2 and HT-29 cells. Curcumin 43-51 epidermal growth factor receptor Homo sapiens 74-78 16170359-7 2006 Promoter deletion assays and site-directed mutageneses identified a binding site for the transcription factor early growth response-1 (Egr-1) in egfr promoter as a putative curcumin response element in regulating the promoter activity of the gene in Moser cells. Curcumin 173-181 epidermal growth factor receptor Homo sapiens 145-149 16170359-10 2006 Taken together, our results demonstrated that curcumin inhibited human colon cancer cell growth by suppressing gene expression of EGFR through reducing the trans-activation activity of Egr-1. Curcumin 46-54 epidermal growth factor receptor Homo sapiens 130-134 15486348-8 2005 In addition, curcumin blocked EGF signaling by inhibiting EGF receptor (EGFR) tyrosine phosphorylation and suppressing the gene expression of EGFR mediated by activation of PPARgamma. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 142-146 16737669-4 2006 However, other studies have suggested that curcumin may also inhibit polyps formation by COX-2 independent mechanisms (eg, inhibition of ErbB-1, AkT). Curcumin 43-51 epidermal growth factor receptor Homo sapiens 137-143 17044774-7 2006 Whereas curcumin inhibited constitutive activation of both EGFR and IGF-1R, ERRP decreased activation of EGFR, ErbB-2, and ErbB-3 but had no effect on IGF-1R. Curcumin 8-16 epidermal growth factor receptor Homo sapiens 59-63 15486348-0 2005 Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR. Curcumin 29-37 epidermal growth factor receptor Homo sapiens 126-130 15486348-8 2005 In addition, curcumin blocked EGF signaling by inhibiting EGF receptor (EGFR) tyrosine phosphorylation and suppressing the gene expression of EGFR mediated by activation of PPARgamma. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 58-70 15486348-8 2005 In addition, curcumin blocked EGF signaling by inhibiting EGF receptor (EGFR) tyrosine phosphorylation and suppressing the gene expression of EGFR mediated by activation of PPARgamma. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 72-76 15486348-10 2005 Taken together, our results demonstrated for the first time that curcumin activation of PPARgamma inhibited Moser cell growth and mediated the suppression of the gene expression of cyclin D1 and EGFR. Curcumin 65-73 epidermal growth factor receptor Homo sapiens 195-199 12527329-3 2003 After pre-treatment of cells for 20 min, curcumin (40 microM) inhibited EGF-stimulated phosphorylation of the EGFR in MDA-MB-468 cells and phosphorylation of extracellular signal regulated kinases (ERKs) 1 and 2, as well as ERK activity and levels of nuclear c-fos in both cell lines. Curcumin 41-49 epidermal growth factor receptor Homo sapiens 110-114 7634398-0 1995 Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Curcumin 104-112 epidermal growth factor receptor Homo sapiens 43-75 10851300-2 2000 Curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 46-78 10851300-3 2000 PURPOSE: In a search for alternative and preventive therapies for prostate cancer, attention was focused on the ways in which curcumin (Turmeric), used in food and medicine in India for centuries, could interfere with the growth factor signaling pathways in both androgen-dependent and androgen-independent prostate cancer cells, as exemplified by the epidermal growth factor receptor (EGF-R) signaling. Curcumin 126-134 epidermal growth factor receptor Homo sapiens 352-384 10851300-3 2000 PURPOSE: In a search for alternative and preventive therapies for prostate cancer, attention was focused on the ways in which curcumin (Turmeric), used in food and medicine in India for centuries, could interfere with the growth factor signaling pathways in both androgen-dependent and androgen-independent prostate cancer cells, as exemplified by the epidermal growth factor receptor (EGF-R) signaling. Curcumin 126-134 epidermal growth factor receptor Homo sapiens 386-391 7634398-3 1995 There was no effect of curcumin treatment on the amount of surface expression of labeled EGF-R and inhibition of EGF-mediated tyrosine phosphorylation of EGF-R by curcumin was mediated by a reversible mechanism. Curcumin 163-171 epidermal growth factor receptor Homo sapiens 154-159 7634398-5 1995 These findings demonstrate that curcumin is a potent inhibitor of a growth stimulatory pathway, the ligand-induced activation of EGF-R, and may potentially be useful in developing anti-proliferative strategies to control tumor cell growth. Curcumin 32-40 epidermal growth factor receptor Homo sapiens 129-134 34804186-10 2021 The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin. Curcumin 42-50 epidermal growth factor receptor Homo sapiens 80-84 7803521-1 1994 We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells. Curcumin 50-58 epidermal growth factor receptor Homo sapiens 90-128 34804186-10 2021 The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin. Curcumin 147-155 epidermal growth factor receptor Homo sapiens 80-84 34994998-0 2022 Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib-resistant melanoma cells by downregulating the EGFR signaling pathway. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 124-128 34994998-9 2022 Curcumin-induced apoptosis was also mediated by the EGFR signaling pathway. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 52-56 34994998-10 2022 Combination treatment with curcumin and gefitinib (an EGFR inhibitor) synergistically potentiated the inhibitory effect of cell viability in A375.S2/VR cells. Curcumin 27-35 epidermal growth factor receptor Homo sapiens 54-58 33003239-0 2021 Curcumin Promotes Collagen Type I, Keratinocyte Growth Factor-1, and Epidermal Growth Factor Receptor Expressions in the In Vitro Wound Healing Model of Human Gingival Fibroblasts. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 69-101 33003239-9 2021 RESULTS: In unwounded hGFs, curcumin significantly increased KGF-1 and EGFR expressions but not COL1 mRNA expression. Curcumin 29-37 epidermal growth factor receptor Homo sapiens 72-76 33003239-10 2021 Interestingly, curcumin significantly upregulated COL1, KGF-1, and EGFR expressions in the in vitro wound healing model. Curcumin 15-23 epidermal growth factor receptor Homo sapiens 67-71 33003239-11 2021 Furthermore, PD98059 significantly decreased the curcumin-induced COL1 and EGFR expressions, but did not significantly affect KGF-1 upregulation by curcumin. Curcumin 49-57 epidermal growth factor receptor Homo sapiens 75-79 33003239-13 2021 CONCLUSION: Curcumin induced KGF-1 and EGFR expressions in unwounded hGFs. Curcumin 13-21 epidermal growth factor receptor Homo sapiens 40-44 33003239-14 2021 In the in vitro wound healing model, curcumin upregulated COL1 and EGFR expression via the ERK pathway and increased KGF-1 expression, possibly by an ERK-independent mechanism. Curcumin 37-45 epidermal growth factor receptor Homo sapiens 67-71