PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28980111-6 2017 In addition, Curcumin administration protects rats against acetamiprid-induced cerebellum toxicity such as increase in AChE and BChE activities, decrease on cells viability, oxidative stress, and an increase of intracellular calcium. Curcumin 13-21 acetylcholinesterase Rattus norvegicus 119-123 33237490-6 2021 In addition, curcumin treatment has been found to cause a significant reduction in AChE activities and MDA levels in synaptosomes (P < 0.05). Curcumin 13-21 acetylcholinesterase Rattus norvegicus 83-87 33237490-7 2021 Co-administration of BA and curcumin on synaptosomes exposed to Abeta1-42 resulted in a significant decrease in DNA fragmentation values, MDA levels, and AChE activities. Curcumin 28-36 acetylcholinesterase Rattus norvegicus 154-158 33548025-2 2021 The present study investigates the efficacy of curcumin nanoparticles against the cardiotoxic effects of cisplatin by assessment of oxidative stress parameters, Na+,K+-ATPase, acetylcholinesterase (AchE) and tumor necrosis factor-alpha (TNF-alpha) in cardiac tissue in addition to serum lactate dehydrogenase (LDH). Curcumin 47-55 acetylcholinesterase Rattus norvegicus 198-202 30772790-6 2019 Our results showed that both curcumin and donepezil improved memory and inhibited acetylcholinesterase, however curcumin inhibited AchE with more potency than donepezil when compared to vehicle control rats. Curcumin 29-37 acetylcholinesterase Rattus norvegicus 82-102 30772790-6 2019 Our results showed that both curcumin and donepezil improved memory and inhibited acetylcholinesterase, however curcumin inhibited AchE with more potency than donepezil when compared to vehicle control rats. Curcumin 112-120 acetylcholinesterase Rattus norvegicus 131-135 28527659-0 2017 Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. Curcumin 0-8 acetylcholinesterase Rattus norvegicus 33-53 28527659-1 2017 Curcumin, the main polyphenolic component of turmeric (Curcuma longa) rhizomes have been reported to exert anticholinesterase potential with limited information on how they regulate acetylcholinesterase (AChE) gene expression. Curcumin 0-8 acetylcholinesterase Rattus norvegicus 182-202 28527659-1 2017 Curcumin, the main polyphenolic component of turmeric (Curcuma longa) rhizomes have been reported to exert anticholinesterase potential with limited information on how they regulate acetylcholinesterase (AChE) gene expression. Curcumin 0-8 acetylcholinesterase Rattus norvegicus 204-208 28527659-2 2017 Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) activity and their mRNA gene expression level in cadmium (Cd)-treated rats. Curcumin 51-59 acetylcholinesterase Rattus norvegicus 79-99 28527659-2 2017 Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) activity and their mRNA gene expression level in cadmium (Cd)-treated rats. Curcumin 51-59 acetylcholinesterase Rattus norvegicus 101-105 28527659-3 2017 Furthermore, in vitro effect of different concentrations of curcumin (1-5mug/mL) on rat cerebral cortex AChE activity was assessed. Curcumin 60-68 acetylcholinesterase Rattus norvegicus 104-108 28527659-8 2017 However, co-treatment with curcumin inhibited AChE activity and alters AChE mRNA levels when compared to Cd-treated group. Curcumin 27-35 acetylcholinesterase Rattus norvegicus 46-50 28527659-8 2017 However, co-treatment with curcumin inhibited AChE activity and alters AChE mRNA levels when compared to Cd-treated group. Curcumin 27-35 acetylcholinesterase Rattus norvegicus 71-75 28527659-9 2017 In addition, curcumin inhibits rat cerebral cortex AChE activity in vitro. Curcumin 13-21 acetylcholinesterase Rattus norvegicus 51-55 28527659-10 2017 In conclusion, curcumin exhibit anti-acetylcholinesterase activity and suppressed AChE mRNA gene expression level in Cd exposed rats, thus providing some biochemical and molecular evidence on the therapeutic effect of this turmeric-derived compound in treating neurological disorders including Alzheimer"s disease. Curcumin 15-23 acetylcholinesterase Rattus norvegicus 37-57 28527659-10 2017 In conclusion, curcumin exhibit anti-acetylcholinesterase activity and suppressed AChE mRNA gene expression level in Cd exposed rats, thus providing some biochemical and molecular evidence on the therapeutic effect of this turmeric-derived compound in treating neurological disorders including Alzheimer"s disease. Curcumin 15-23 acetylcholinesterase Rattus norvegicus 82-86 28102474-9 2017 However, combination of curcumin and donepezil improves learning and memory activity associated with inhibitory effect on AChE, BuChE, and ADA activities as compared to control. Curcumin 24-32 acetylcholinesterase Rattus norvegicus 122-126 22783142-7 2012 Curcumin when co-supplemented with 2-PAMCl + atropine also significantly protected serum aspartate aminotransferase (AST) and restored brain AChE activity and 5-HT level in animals sub-chronically exposed to DDVP. Curcumin 0-8 acetylcholinesterase Rattus norvegicus 141-145 27491636-2 2017 Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities in cadmium (Cd)-induced memory impairment in rats. Curcumin 51-59 acetylcholinesterase Rattus norvegicus 79-99 27491636-2 2017 Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities in cadmium (Cd)-induced memory impairment in rats. Curcumin 51-59 acetylcholinesterase Rattus norvegicus 101-105 28605332-3 2017 Against carbofuran, curcumin restored the activities of acetylcholinesterase, LDH, CK and gamma- GT in animals. Curcumin 20-28 acetylcholinesterase Rattus norvegicus 56-76 22579739-0 2012 Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats. Curcumin 0-8 acetylcholinesterase Rattus norvegicus 85-105 27491636-0 2017 Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model. Curcumin 0-8 acetylcholinesterase Rattus norvegicus 93-113 25982942-7 2015 In addition, curcumin significantly reduced the level of MDA and increased the activities of SOD and AChE. Curcumin 13-21 acetylcholinesterase Rattus norvegicus 101-105 21932293-0 2011 The effect of curcumin in the ectonucleotidases and acetylcholinesterase activities in synaptosomes from the cerebral cortex of cigarette smoke-exposed rats. Curcumin 14-22 acetylcholinesterase Rattus norvegicus 52-72 21932293-4 2011 Curcumin prevented the increased NTPDase, 5"-nucleotidase and AChE activities caused by smoke exposure. Curcumin 0-8 acetylcholinesterase Rattus norvegicus 62-66 20026275-7 2010 Furthermore, STZ (ICV) resulted into enhanced AChE activity in hippocampus and cerebral cortex which was normalized by curcumin pre- and post-treatment. Curcumin 119-127 acetylcholinesterase Rattus norvegicus 46-50 21839772-5 2011 Simultaneous treatment with arsenic and curcumin (100mg/kg body weight, p.o., 28 days) increased learning and memory performance associated with increased binding of (3)H-QNB in hippocampus (54%), frontal cortex (25%) and activity of acetylcholinesterase in hippocampus (41%) and frontal cortex (29%) as compared to arsenic treated rats. Curcumin 40-48 acetylcholinesterase Rattus norvegicus 234-254 19020987-4 2009 In animals co-administered with curcumin and aluminium, the levels of lipid peroxidation, activities of PKC and AChE were significantly lowered while the activities of SOD, GPx, GST and Na(+), K(+)-ATPase were significantly enhanced in the two brain regions studied indicating curcumin"s protective effects against aluminium toxicity. Curcumin 32-40 acetylcholinesterase Rattus norvegicus 112-116 19616038-13 2009 Chronic administration of curcumin significantly improved memory retention in both tasks, attenuated oxidative damage, acetylcholinesterase activity and aluminium concentration in aluminium treated rats (P<0.05). Curcumin 26-34 acetylcholinesterase Rattus norvegicus 119-139 19020987-5 2009 Though the magnitudes of curcumin-induced alterations varied in young and old animals, the results of the present study also demonstrated that curcumin exerts a protective effect against aluminium-induced elevation of ageing-related changes by modulating the extent of oxidative stress (by upregulating the activities of antioxidant enzymes) and by regulating the activities of Na(+), K(+) ATPase, PKC and AChE. Curcumin 143-151 acetylcholinesterase Rattus norvegicus 406-410 18930076-4 2009 Curcuminoids inhibited AChE in the in-vitro assay with IC(50) value of 19.67, bisdemethoxycurcumin 16.84, demethoxycurcumin 33.14 and curcumin 67.69 microM. Curcumin 90-98 acetylcholinesterase Rattus norvegicus 23-27 18930076-5 2009 In the ex-vivo AChE assay, curcuminoids and its individual components except curcumin showed dose-dependent (3-10 mg/kg) inhibition in frontal cortex and hippocampus. Curcumin 27-35 acetylcholinesterase Rattus norvegicus 15-19 18930076-7 2009 These data indicate that curcuminoids and all individual components except curcumin possess pronounced AChE inhibitory activity. Curcumin 25-33 acetylcholinesterase Rattus norvegicus 103-107 18809455-9 2008 Moreover, curcumin induced Sa-reduced liver transaminases and phosphatases, plasma and brain AChE, and the levels of TP and Alb. Curcumin 10-18 acetylcholinesterase Rattus norvegicus 93-97