PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34361702-2 2021 Over the last decade, many innovative curcumin-based compounds have been designed and synthesized, searching for new derivatives having anti-amyloidogenic, inhibitory of tau formation, as well as anti-neuroinflammation, antioxidative, and AChE inhibitory activities. Curcumin 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 239-243 32785161-0 2020 Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches. Curcumin 10-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Curcumin 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Curcumin 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Curcumin 300-308 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 32785161-5 2020 A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models. Curcumin 69-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 32717861-4 2020 Here, we combine GAL core with CU fragments and design a combinatorial library of GAL-CU hybrids as dual-site binding AChE inhibitors. Curcumin 31-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 31507403-7 2019 Of the four compounds screened, only curcumin (-9.6 kcal/mol) and piperine (-10.5 kcal/mol) showed favorable binding affinities and interactions towards AChE and were hence selected. Curcumin 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 32118214-1 2020 In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin. Curcumin 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32118214-1 2020 In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin. Curcumin 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 31507403-8 2019 In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml. Curcumin 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 31507403-8 2019 In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml. Curcumin 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 25446495-0 2015 A combined molecular docking and charge density analysis is a new approach for medicinal research to understand drug-receptor interaction: curcumin-AChE model. Curcumin 139-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 27897077-1 2017 Acetylcholinesterase (AChE) is an important enzyme responsible for Alzheimer"s disease, as per report, keto-enol form of curcumin inhibits this enzyme. Curcumin 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27897077-1 2017 Acetylcholinesterase (AChE) is an important enzyme responsible for Alzheimer"s disease, as per report, keto-enol form of curcumin inhibits this enzyme. Curcumin 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 25446495-1 2015 In the present study, a molecular docking analysis has been performed on diketone form of curcumin molecule with acetylcholinesterase (AChE). Curcumin 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 25446495-1 2015 In the present study, a molecular docking analysis has been performed on diketone form of curcumin molecule with acetylcholinesterase (AChE). Curcumin 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 25446495-2 2015 The calculated lowest docked energy of curcumin molecule in the active site of AChE is -11.21 kcal/mol; this high negative value indicates that the molecule exhibits large binding affinity towards AChE. Curcumin 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 25446495-2 2015 The calculated lowest docked energy of curcumin molecule in the active site of AChE is -11.21 kcal/mol; this high negative value indicates that the molecule exhibits large binding affinity towards AChE. Curcumin 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 25446495-3 2015 When the curcumin molecule present in the active site of AChE, subsequently, its conformation has altered significantly and the molecule adopts a U-shape geometry as it is linear in gas phase (before entering into the active site). Curcumin 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 23501115-4 2013 Besides, compounds showed higher activity of inhibiting AChE-induced amyloid-beta (Abeta) aggregation than curcumin, higher anti-oxidative activity than Trolox, and could also be good metal chelators. Curcumin 107-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60