PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32782494-9 2020 However, pretreatment with curcumin increased the expression of ABCA1 and cholesterol efflux and suppressed secretion of TNF-alpha, MCP-1 and Il-6. Curcumin 27-35 C-C motif chemokine ligand 2 Homo sapiens 132-137 33923651-0 2021 Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 49-54 33923651-3 2021 Monocyte chemoattractant protein-1 (MCP-1) is a key inflammatory marker during the development of atherosclerosis, and curcumin blocks MCP-1 expression stimulated by various ligands. Curcumin 119-127 C-C motif chemokine ligand 2 Homo sapiens 135-140 33923651-4 2021 Hence, we studied the action of curcumin on lysophosphatidic acid (LPA) mediated MCP-1 expression and explored the specific underlying mechanisms. Curcumin 32-40 C-C motif chemokine ligand 2 Homo sapiens 81-86 33923651-7 2021 Curcumin blocks LPA mediated TGFBR1 transactivation and subsequent MCP-1 expression by blocking the ROCK signalling. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 67-72 34014157-0 2021 Curcumin alleviates inflammation in Takayasu"s arteritis by blocking CCL2 overexpression in adventitial fibroblasts. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 69-73 34014157-8 2021 RT-qPCR, ELISA and western blot were used to determine the regulatory effect of curcumin on CCL2 expression in aortic adventitia fibroblasts (AAFs) and its mechanism. Curcumin 80-88 C-C motif chemokine ligand 2 Homo sapiens 92-96 34014157-9 2021 RESULTS: Curcumin treatment significantly lowered Kerr score and the levels of serum CCL2 in TAK patients. Curcumin 9-17 C-C motif chemokine ligand 2 Homo sapiens 85-89 34014157-12 2021 After curcumin treatment, the changes in CCL2 were positively associated with the changes in IL-6. Curcumin 6-14 C-C motif chemokine ligand 2 Homo sapiens 41-45 34014157-15 2021 Nevertheless, curcumin could reverse the HSP65-induced CCL2 upregulation through restraining JAK2/AKT/STAT3 pathway. Curcumin 14-22 C-C motif chemokine ligand 2 Homo sapiens 55-59 34014157-17 2021 CONCLUSIONS: Curcumin alleviated inflammation in TAK by downregulating CCL2 overexpression in AAFs through inhibiting the JAK2/AKT/STAT3 signalling pathway. Curcumin 13-21 C-C motif chemokine ligand 2 Homo sapiens 71-75 32782494-0 2020 Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 49-54 31947962-5 2020 Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT. Curcumin 31-39 C-C motif chemokine ligand 2 Homo sapiens 265-299 32430842-9 2020 Our data also revealed that CM-NP could significantly reduce the invasiveness of GSCs compared with CM, possibly via MCP-1-mediated pathways. Curcumin 28-30 C-C motif chemokine ligand 2 Homo sapiens 117-122 31947962-5 2020 Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT. Curcumin 31-39 C-C motif chemokine ligand 2 Homo sapiens 301-306 31593984-5 2019 Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels. Curcumin 24-32 C-C motif chemokine ligand 2 Homo sapiens 160-165 31665675-5 2019 We also found that TNF-alpha-enhanced protein expressions of vascular cell adhesion molecule 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and nuclear factor (NF)-kappaB translocation were synergistically reduced by the combined curcumin and luteolin in EA.hy 926 cells while the individual chemical did not have this inhibitory effect. Curcumin 234-242 C-C motif chemokine ligand 2 Homo sapiens 105-135 31665675-7 2019 Therefore, combined curcumin and luteolin at physiological concentrations synergistically inhibits TNF-alpha-induced monocytes adhesion to endothelial cells and expressions of MCP-1 and VCAM-1 via suppressing NF-kappaB translocation into the nucleus. Curcumin 20-28 C-C motif chemokine ligand 2 Homo sapiens 176-181 31630418-7 2020 After blocking Act1/TRAF6/p38MAPK cascade and interfering AP-1 with Curcumin or c-Jun siRNA, CCL2 expression induced by IL-17 was significantly attenuated at both mRNA and protein levels. Curcumin 68-76 C-C motif chemokine ligand 2 Homo sapiens 93-97 29460119-9 2018 These results could shed light on understanding of the molecular basis for the inhibition of Curcumin on MCP-1 expression during the process of astrocyte activation, and provide a molecular mechanism for using Curcumin in neuropathic pain. Curcumin 93-101 C-C motif chemokine ligand 2 Homo sapiens 105-110 29460119-0 2018 Curcumin Inhibits Monocyte Chemoattractant Protein-1 Expression in TNF-alpha induced Astrocytes Through AMPK Pathway. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 18-52 29460119-6 2018 Our data demonstrated that Curcumin inhibited TNF-alpha-induced astrocytes migration, decreased MCP-1 expression, and up-regulated SOD2 expression in TNF-alpha-induced astrocytes in vitro. Curcumin 27-35 C-C motif chemokine ligand 2 Homo sapiens 96-101 28914666-5 2018 The pleiotropic nonselective MCP-1/CCR2 inhibition by current pharmacological agents is thought to contribute to their anti-inflammatory and antiatherosclerotic effects that is also seen for nutraceutical compounds such as curcumin. Curcumin 223-231 C-C motif chemokine ligand 2 Homo sapiens 29-34 17666914-6 2007 The expression of intracellular cell adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1, and interleukin (IL)-8 were attenuated by curcumin at both mRNA and protein level. Curcumin 149-157 C-C motif chemokine ligand 2 Homo sapiens 65-105 27743775-0 2017 Curcumin as a natural regulator of monocyte chemoattractant protein-1. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 35-69 27743775-5 2017 The purpose of this review is to evaluate the effects of curcumin on the regulation of MCP-1 as a key mediator of chemotaxis and inflammation, and the biological consequences thereof. Curcumin 57-65 C-C motif chemokine ligand 2 Homo sapiens 87-92 27743775-7 2017 Animal studies have also revealed that curcumin can attenuate MCP-1 expression and improve a range of inflammatory diseases through multiple molecular targets and mechanisms of action. Curcumin 39-47 C-C motif chemokine ligand 2 Homo sapiens 62-67 27743775-8 2017 There is limited data from human clinical trials showing the decreasing effect of curcumin on MCP-1 concentrations and improvement of the course of inflammatory diseases. Curcumin 82-90 C-C motif chemokine ligand 2 Homo sapiens 94-99 27743775-9 2017 Most of the in vitro and animal studies confirm that curcumin exert its MCP-1-lowering and anti-inflammatory effects by down-regulating the mitogen-activated protein kinase (MAPK) and NF-kappaB signaling pathway. Curcumin 53-61 C-C motif chemokine ligand 2 Homo sapiens 72-77 27743775-10 2017 As yet, there is limited data from human clinical trials showing the effect of curcumin on MCP-1 levels and improvement of the course of inflammatory diseases. Curcumin 79-87 C-C motif chemokine ligand 2 Homo sapiens 91-96 27888616-9 2016 Finally, we reported that curcumin, a powerful natural drug, suppressed the production of EGF and CCL2 in macrophages and cancer cells, respectively, blocking the feedback loop and suppressing the migration and invasion of HNSCC cells. Curcumin 26-34 C-C motif chemokine ligand 2 Homo sapiens 98-102 25064633-11 2014 CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis. Curcumin 12-20 C-C motif chemokine ligand 2 Homo sapiens 32-37 22674286-11 2012 Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA. Curcumin 277-285 C-C motif chemokine ligand 2 Homo sapiens 18-22 22183741-7 2012 In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-alpha-induced secretion of IL-6, IL-8 and MCP-1. Curcumin 59-67 C-C motif chemokine ligand 2 Homo sapiens 133-138 19766691-0 2010 Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 58-63 19766691-3 2010 We found that curcumin, a natural biologically active compound extracted from rhizomes of Curcuma species, significantly inhibited the PMA-induced increase in MCP-1 expression and secretion. Curcumin 14-22 C-C motif chemokine ligand 2 Homo sapiens 159-164 19766691-4 2010 These effects of curcumin are dose dependent and correlate with the suppression of MCP-1 mRNA expression levels. Curcumin 17-25 C-C motif chemokine ligand 2 Homo sapiens 83-88 19766691-6 2010 Therefore, one possible anti-inflammatory mechanism of curcumin may be to inhibit the secretions of inflammatory MCP-1 chemokine. Curcumin 55-63 C-C motif chemokine ligand 2 Homo sapiens 113-118 27470399-6 2016 Within-group analysis revealed significant reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 following curcumin supplementation (p<0.001). Curcumin 127-135 C-C motif chemokine ligand 2 Homo sapiens 111-116 27470399-8 2016 Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 in the curcumin versus placebo group (p<0.001). Curcumin 138-146 C-C motif chemokine ligand 2 Homo sapiens 125-130 26767865-8 2016 Pre-treatment with a p38 inhibitor, a JNK inhibitor, or curcumin significantly inhibited Ang III-induced MCP-1 production. Curcumin 56-64 C-C motif chemokine ligand 2 Homo sapiens 105-110 25064633-0 2014 Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 18-52 25064633-1 2014 OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. Curcumin 40-48 C-C motif chemokine ligand 2 Homo sapiens 52-86 25064633-1 2014 OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. Curcumin 40-48 C-C motif chemokine ligand 2 Homo sapiens 88-93 25064633-6 2014 RESULTS: Curcumin decreased the production of MCP-1 induced by ox-LDL in macrophages. Curcumin 9-17 C-C motif chemokine ligand 2 Homo sapiens 46-51 22973975-7 2012 Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor. Curcumin 44-52 C-C motif chemokine ligand 2 Homo sapiens 175-209 23185512-4 2012 CCL2-mediated VCAM-1 expression was attenuated by CCR2 inhibitor (RS102895), PKCdelta inhibitor (rottlerin), p38MAPK inhibitor (SB203580), and AP-1 inhibitors (curcumin and tanshinone IIA). Curcumin 160-168 C-C motif chemokine ligand 2 Homo sapiens 0-4 35011106-8 2022 Curcumin significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-gamma, and IL-4) and lipid peroxidation. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 66-71 15569263-6 2004 Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 113-118 34981477-0 2021 The Role of Chemokines in Cardiovascular Diseases and the Therapeutic Effect of Curcumin on CXCL8 and CCL2 as Pathological Chemokines in Atherosclerosis. Curcumin 80-88 C-C motif chemokine ligand 2 Homo sapiens 102-106 35606882-5 2022 The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). Curcumin 50-58 C-C motif chemokine ligand 2 Homo sapiens 84-89 35606882-5 2022 The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). Curcumin 115-123 C-C motif chemokine ligand 2 Homo sapiens 84-89 35015114-7 2022 In retinal ischemia reperfusion injury, curcumin downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK. Curcumin 40-48 C-C motif chemokine ligand 2 Homo sapiens 91-96 16358608-10 2005 Curcumin (AP-1 inhibitor) markedly suppressed the TNF-alpha-induced CCL2 expression. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 68-72 15022320-13 2004 PD 98059, fludarabine, piceatannol, and curcumin (AP-1 inhibitor) inhibited the OSM-induced expression of CCL2. Curcumin 40-48 C-C motif chemokine ligand 2 Homo sapiens 106-110 14728887-13 2003 CONCLUSION: Curcumin could inhibit the human mesangial cell proliferation and alter the extracellular matrix turnover, meanwhile it could down-regulate the IL-1 beta and MCP-1 mRNA expression induced by LPS, which may be valuable in decreasing the progression of glomerulosclerosis. Curcumin 12-20 C-C motif chemokine ligand 2 Homo sapiens 170-175 11422736-14 2001 Curcumin, an inhibitor of AP-1, dose-dependently suppressed the induction of MCP-1 mRNA by high glucose. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 77-82 11053056-6 2000 Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin. Curcumin 81-89 C-C motif chemokine ligand 2 Homo sapiens 119-124 10051376-5 1999 Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 55-60 10051376-6 1999 These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages. Curcumin 24-32 C-C motif chemokine ligand 2 Homo sapiens 102-107