PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32370057-0 2020 Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 102-106 33907586-9 2021 The role of the CHOP target gene in curcumin-induced ACC cell apoptosis was verified via lentiviral transfection experiments. Curcumin 36-44 DNA damage inducible transcript 3 Homo sapiens 16-20 27677346-8 2017 In addition, curcumin and IFN-beta/RA combination inhibited the expression of COX-2 and up-regulated GADD153. Curcumin 13-21 DNA damage inducible transcript 3 Homo sapiens 101-108 25980682-6 2016 CHOP, a key factor involved in ER stress-mediated apoptosis, was also activated by curcumin. Curcumin 83-91 DNA damage inducible transcript 3 Homo sapiens 0-4 27996348-6 2017 Meanwhile, curcumin pretreatment prevented FZD induced ER stress, evidenced by the inhibition of glucose-regulated protein 78 and DNA damage inducible gene 153/C/EBP-homologous protein (GADD153/CHOP) protein expression. Curcumin 11-19 DNA damage inducible transcript 3 Homo sapiens 186-193 27996348-6 2017 Meanwhile, curcumin pretreatment prevented FZD induced ER stress, evidenced by the inhibition of glucose-regulated protein 78 and DNA damage inducible gene 153/C/EBP-homologous protein (GADD153/CHOP) protein expression. Curcumin 11-19 DNA damage inducible transcript 3 Homo sapiens 194-198 25039189-7 2014 Curcumin could significantly increase the expression levels of GRP78 and CHOP in breast cancer cells. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 73-77 26013662-7 2015 Mechanistic investigations revealed that curcumin treatment upregulated the ER stress markers CHOP and Bip/GRP78 and the autophagic marker LC3-II. Curcumin 41-49 DNA damage inducible transcript 3 Homo sapiens 94-98 24625971-0 2014 Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin. Curcumin 129-137 DNA damage inducible transcript 3 Homo sapiens 43-47 17171638-0 2007 Curcumin-induced GADD153 upregulation: modulation by glutathione. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 17-24 23881281-4 2013 Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells. Curcumin 11-19 DNA damage inducible transcript 3 Homo sapiens 125-174 23881281-4 2013 Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells. Curcumin 11-19 DNA damage inducible transcript 3 Homo sapiens 176-180 23881281-9 2013 siRNA to CHOP markedly reduced curcumin-induced apoptosis. Curcumin 31-39 DNA damage inducible transcript 3 Homo sapiens 9-13 23415873-7 2013 Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells. Curcumin 13-21 DNA damage inducible transcript 3 Homo sapiens 157-161 23415873-8 2013 In PHA-activated T cells, curcumin further enhanced PHA-induced CHOP expression and reduced the expression of the anti-apoptotic protein Bcl-2. Curcumin 26-34 DNA damage inducible transcript 3 Homo sapiens 64-68 23415873-9 2013 Finally, curcumin treatment induced apoptotic cell death in activated T cells via eliciting an excessive ER stress response, which was reversed by the ER-stress inhibitor 4-phenylbutyric acid or transfection with CHOP-specific siRNA. Curcumin 9-17 DNA damage inducible transcript 3 Homo sapiens 213-217 20878089-11 2010 Curcumin induces the GADD153 expression by cleaving caspase-12 and ATF6, and then by translocating ATF6 to the nucleus. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 21-28 20651361-9 2010 Curcumin-induced apoptosis was also stimulated through the FAS/caspase-8 (extrinsic) pathway and ER stress proteins, growth arrest- and DNA damage-inducible gene 153 (GADD153) and glucose-regulated protein 78 (GRP78) were activated in the NCI-H460 cells. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 117-165 20651361-9 2010 Curcumin-induced apoptosis was also stimulated through the FAS/caspase-8 (extrinsic) pathway and ER stress proteins, growth arrest- and DNA damage-inducible gene 153 (GADD153) and glucose-regulated protein 78 (GRP78) were activated in the NCI-H460 cells. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 167-174 23415873-7 2013 Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells. Curcumin 13-21 DNA damage inducible transcript 3 Homo sapiens 131-155 21282356-5 2011 Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 99-103 18701210-5 2008 GADD153 and GRP78 were increased by curcumin which was indicative of ER stress. Curcumin 36-44 DNA damage inducible transcript 3 Homo sapiens 0-7 17171638-1 2007 As we reported previously, GADD153 is upregulated in colon cancer cells exposed to curcumin. Curcumin 83-91 DNA damage inducible transcript 3 Homo sapiens 27-34 17171638-2 2007 In the present study, we ascertained the involvement of glutathione and certain sulfhydryl enzymes associated with signal transduction in mediating the effect of curcumin on GADD153. Curcumin 162-170 DNA damage inducible transcript 3 Homo sapiens 174-181 17171638-3 2007 Curcumin-induced GADD153 gene upregulation was attenuated by reduced glutathione (GSH) or N-acetylcysteine (NAC) and potentiated by the glutathione synthesis inhibitor, L-buthionine-(S,R)-sulfoximine (BSO). Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 17-24 17171638-6 2007 In affecting the thiol redox status, curcumin caused activation of certain sulfhydryl enzymes involved in signal transduction linked to GADD153 expression. Curcumin 37-45 DNA damage inducible transcript 3 Homo sapiens 136-143 17171638-8 2007 Furthermore, selective inhibitors of PI3K and PKC-delta attenuated curcumin-induced GADD153 upregulation. Curcumin 67-75 DNA damage inducible transcript 3 Homo sapiens 84-91 17171638-9 2007 Collectively, these findings suggest that a regulatory thiol redox-sensitive signaling cascade exists in the molecular pathway leading to induction of GADD153 expression as caused by curcumin. Curcumin 183-191 DNA damage inducible transcript 3 Homo sapiens 151-158 34832850-4 2021 Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlation with the induction of a stronger ER stress and the upregulation of pro-death UPR molecule CHOP. Curcumin 40-48 DNA damage inducible transcript 3 Homo sapiens 205-209 34146894-4 2021 To this end, we detected transcription factor 6 (ATF6), the key factor of regulating lipid metabolism along with other related molecules (CHOP and GPR78) and found that curcumin significantly impaired the gene synthesis of ATF6, while CSFV infection promoted ATF6 expression. Curcumin 169-177 DNA damage inducible transcript 3 Homo sapiens 138-142 35300350-10 2021 Interestingly, lower expression of miR-27a by curcumin action enhanced the C/EBP homologous protein(CHOP) expression, leading to paraptosis. Curcumin 46-54 DNA damage inducible transcript 3 Homo sapiens 100-104 17198682-3 2007 In HL-60 cells, curcumin induced apoptosis and endoplasmic reticulum (ER) stress as evidenced by the survival molecules such as phosphorylated protein kinase-like ER-resident kinase, phosphorylated eukaryotic initiation factor-2alpha, glucose-regulated protein-78, and the apoptotic molecules such as caspase-4 and CAAT/enhancer binding protein homologous protein (CHOP). Curcumin 16-24 DNA damage inducible transcript 3 Homo sapiens 365-369 17198682-4 2007 Inhibition of caspase-4 activity by z-LEVD-FMK, blockage of CHOP expression by small interfering RNA, and treatment with salubrinal, an ER inhibitor, significantly reduced curcumin-induced apoptosis. Curcumin 172-180 DNA damage inducible transcript 3 Homo sapiens 60-64 16613838-0 2006 Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 111-115 16613838-4 2006 Curcumin also induced the expression of a potential pro-apoptotic gene, C/EBP homologous protein (CHOP), both at its mRNA and protein levels. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 72-96 16613838-4 2006 Curcumin also induced the expression of a potential pro-apoptotic gene, C/EBP homologous protein (CHOP), both at its mRNA and protein levels. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 98-102 16613838-6 2006 Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by CHOP-independent upregulation of DR5. Curcumin 52-60 DNA damage inducible transcript 3 Homo sapiens 97-101 16464750-4 2006 Like other proteasome inhibitors, curcumin exposure induces neurite outgrowth and the stress response, as evident from the induction of various cytosolic and endoplasmic reticulum chaperones as well as induction of transcription factor CHOP/GADD153. Curcumin 34-42 DNA damage inducible transcript 3 Homo sapiens 236-240 16464750-4 2006 Like other proteasome inhibitors, curcumin exposure induces neurite outgrowth and the stress response, as evident from the induction of various cytosolic and endoplasmic reticulum chaperones as well as induction of transcription factor CHOP/GADD153. Curcumin 34-42 DNA damage inducible transcript 3 Homo sapiens 241-248 15271854-0 2004 Curcumin-induced GADD153 gene up-regulation in human colon cancer cells. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 17-24 15271854-5 2004 To identify a potential pro-apoptotic gene that could be responsive to the DNA damage in curcumin-treated cells, growth arrest and DNA damage-inducible gene 153 (GADD153) was considered. Curcumin 89-97 DNA damage inducible transcript 3 Homo sapiens 113-160 15271854-5 2004 To identify a potential pro-apoptotic gene that could be responsive to the DNA damage in curcumin-treated cells, growth arrest and DNA damage-inducible gene 153 (GADD153) was considered. Curcumin 89-97 DNA damage inducible transcript 3 Homo sapiens 162-169 15271854-6 2004 Curcumin increased GADD153 mRNA (and also protein) expression, which was prevented by actinomycin D and also by a broad protein kinase C inhibitor, but not by selective MAPK inhibitors. Curcumin 0-8 DNA damage inducible transcript 3 Homo sapiens 19-26 15271854-7 2004 These findings suggest that curcumin-induced up-regulation of GADD153 mRNA expression was at the level of transcription, but apparently without depending on upstream MAPK. Curcumin 28-36 DNA damage inducible transcript 3 Homo sapiens 62-69 15271854-8 2004 In determining the involvement of reactive oxygen species in mediating the effect of curcumin on GADD153, the antioxidants pyrrolidine dithiocarbamate and N-acetylcysteine (NAC), but neither alpha-tocopherol nor catalase, also blunted or prevented up-regulation of GADD153 mRNA expression caused by curcumin. Curcumin 85-93 DNA damage inducible transcript 3 Homo sapiens 97-104 15271854-10 2004 Because expression of GADD153 protein was detected before the appearance of apoptotic features, this observation raises the possibility that GADD153 protein might be important for curcumin-induced apoptosis. Curcumin 180-188 DNA damage inducible transcript 3 Homo sapiens 22-29 15271854-10 2004 Because expression of GADD153 protein was detected before the appearance of apoptotic features, this observation raises the possibility that GADD153 protein might be important for curcumin-induced apoptosis. Curcumin 180-188 DNA damage inducible transcript 3 Homo sapiens 141-148 34659400-8 2021 The protein levels of oxidative stress markers inducible nitric oxide synthase (iNOS) and gammaH2AX and ERS-induced apoptosis-related molecules C/EBP homologous protein (CHOP) and cleaved caspase-12 were significantly downregulated upon curcumin treatment. Curcumin 237-245 DNA damage inducible transcript 3 Homo sapiens 144-168 34659400-8 2021 The protein levels of oxidative stress markers inducible nitric oxide synthase (iNOS) and gammaH2AX and ERS-induced apoptosis-related molecules C/EBP homologous protein (CHOP) and cleaved caspase-12 were significantly downregulated upon curcumin treatment. Curcumin 237-245 DNA damage inducible transcript 3 Homo sapiens 170-174 34659400-9 2021 Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2alpha- (eIF2alpha-) activating transcription factor 4- (ATF4-) CHOP signaling pathway. Curcumin 13-21 DNA damage inducible transcript 3 Homo sapiens 220-224