PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31028577-5 2019 Western blot and immunocytochemistry studies revealed that pretreatment of A549 cells with curcumin for 3 h before PQ exposure has maintained E-cadherin expression and inhibited PQ induced alpha-smooth-muscle actin (alpha-SMA) expression. Curcumin 91-99 cadherin 1 Homo sapiens 142-152 32893845-12 2020 The expression levels of E-cadherin were increased in a curcumin concentration-dependent manner. Curcumin 56-64 cadherin 1 Homo sapiens 25-35 31511210-6 2019 In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin. Curcumin 30-38 cadherin 1 Homo sapiens 261-271 33179087-8 2021 Furthermore, curcumin notably decreased the expression levels of epithelial marker E-cadherin and markedly increased the expression levels of mesenchymal marker N-cadherin in MCF-7/TAMR cells compared with the control group. Curcumin 13-21 cadherin 1 Homo sapiens 83-93 33179087-10 2021 Moreover, curcumin treatment for 48 h significantly attenuated H19-induced alterations in N-cadherin and E-cadherin expression levels. Curcumin 10-18 cadherin 1 Homo sapiens 105-115 32377752-16 2020 In addition, curcumin and IL-6-neutralizing antibody treatment suppressed PSC-CM-modulated pancreatic cancer invasion, EMT and the changes in the expression of E-cadherin, vimentin and matrix metallopeptidase-9. Curcumin 13-21 cadherin 1 Homo sapiens 160-170 33124505-0 2020 Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression. Curcumin 0-8 cadherin 1 Homo sapiens 168-178 30542713-13 2019 In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin. Curcumin 126-134 cadherin 1 Homo sapiens 97-107 31602860-7 2019 Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well. Curcumin 9-17 cadherin 1 Homo sapiens 195-205 31143210-13 2019 Real-time RT-PCR and western blot revealed that, compared to the 4.25% Dianeal treated cells, curcumin treatment resulted in increased expression of E-cadherin (epithelial marker), and decreased expression of alpha-SMA (mesenchymal markers) (P < 0.05). Curcumin 94-102 cadherin 1 Homo sapiens 149-159 31005718-12 2019 Moreover, curcumin down-regulated the mRNA expression of Vimentin, Fibronectin, and beta-catenin, and up-regulated E-cadherin mRNA expression levels. Curcumin 10-18 cadherin 1 Homo sapiens 115-125 29801408-8 2018 Theresults showed that administration of curcumin in all the dose administered were incapable improving the expressionsof vimentin, TGF-beta1 and E-cadherin. Curcumin 41-49 cadherin 1 Homo sapiens 146-156 29600521-8 2018 Curcumin reduced the invasiveness of MCF-7 through perturbation of E-cadherin. Curcumin 0-8 cadherin 1 Homo sapiens 67-77 27829579-7 2017 When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin. Curcumin 47-55 cadherin 1 Homo sapiens 252-262 29420338-9 2018 After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated. Curcumin 6-14 cadherin 1 Homo sapiens 133-143 29420338-9 2018 After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated. Curcumin 96-104 cadherin 1 Homo sapiens 133-143 27829579-7 2017 When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin. Curcumin 66-74 cadherin 1 Homo sapiens 252-262 26302188-5 2015 However, curcumin reversed the morphological changes, abrogated the increased expression of mesenchymal markers, and rescued E-cadherin expression in CoCl2-treated hepatocytes, suggesting the inhibition of hepatocyte EMT in vitro. Curcumin 9-17 cadherin 1 Homo sapiens 125-135 27082017-7 2016 Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB. Curcumin 23-31 cadherin 1 Homo sapiens 130-140 26826337-5 2016 Herein, we demonstrated that curcumin remarkably increased the expression of the epithelial marker E-cadherin and repressed the expression of the mesenchymal marker vimentin in human papillary thyroid carcinoma BCPAP cells. Curcumin 29-37 cadherin 1 Homo sapiens 99-109 26036622-0 2015 Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway. Curcumin 0-8 cadherin 1 Homo sapiens 167-177 26036622-5 2015 RESULTS: Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression. Curcumin 30-38 cadherin 1 Homo sapiens 217-227 23544048-8 2013 Further, the effect of curcumin on alpha-SMA, PAI-1, E-cadherin, TbetaR I and TbetaR II were reversed by ERK inhibitor U0126 or PPARgamma inhibitor BADGE, or PPARgamma shRNA. Curcumin 23-31 cadherin 1 Homo sapiens 53-63 25349216-6 2015 Furthermore, curcumin enhances E-cadherin expression, inhibits metalloproteinase-9 (MMP-9) enzyme activity, and weakens K1 cells migration under hypoxic conditions. Curcumin 13-21 cadherin 1 Homo sapiens 31-41 25315241-0 2014 Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/beta-catenin negative feedback loop. Curcumin 0-8 cadherin 1 Homo sapiens 70-80 25315241-8 2014 RESULTS: Here, we report that bCSCs are endowed with aggravated migration property due to the inherent suppression of the tumor suppressor, E-cadherin, which is restored by curcumin. Curcumin 173-181 cadherin 1 Homo sapiens 140-150 25315241-12 2014 CONCLUSIONS: Cumulatively, our findings disclose that curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative feedback loop. Curcumin 54-62 cadherin 1 Homo sapiens 101-111 24570592-0 2014 Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver metastases via modulating matrix metalloproteinase-9 and E-cadherin expression. Curcumin 50-58 cadherin 1 Homo sapiens 174-184 24570592-2 2014 The current study was to investigate the ability of ulinastatin (UTI) and curcumin (CUR) to inhibit CRC liver metastases via modulating matrix metalloproteinase-9 (MMP-9) and E-cadherin expression. Curcumin 74-82 cadherin 1 Homo sapiens 175-185 24369238-6 2013 Curcumin inhibited the invasion and migration of HeLa cells by increasing E-cad expression and decreasing MMP-9 expression, and also decreased the expression level of iNOS and NO production in the cells. Curcumin 0-8 cadherin 1 Homo sapiens 74-79 24325063-7 2013 Intervention by curcumin significantly inhibited the proliferation and migration of hypoxic HepG2 cells, and expressions of HIF-1alpha and vimentin decreased, and the expression of E-cadherin was up-regulated, showing statistical difference when compared with those of the CoCl2 group (P < 0.05). Curcumin 16-24 cadherin 1 Homo sapiens 181-191 23474829-0 2013 Curcumin inhibits the metastasis of K1 papillary thyroid cancer cells via modulating E-cadherin and matrix metalloproteinase-9 expression. Curcumin 0-8 cadherin 1 Homo sapiens 85-95 23563640-9 2013 The expression level of E-cadherin in the curcumin-treated group was significantly increased compared with that in the control group (P<0.01). Curcumin 42-50 cadherin 1 Homo sapiens 24-34 23076367-3 2013 In this study, we used lipopolysaccharide (LPS) to trigger EMT in MCF-7 and MDA-MB-231 breast cancer cell lines and showed that curcumin inhibited LPS-induced morphological changes, decreased the expression of LPS-induced markers of EMT such as vimentin, and increased the expression of E-cadherin, resulting in the inhibition of in vitro cell motility and invasiveness. Curcumin 152-160 cadherin 1 Homo sapiens 335-345 23544048-4 2013 We found that curcumin inhibited the EMT as assessed by reduced expression of alpha-SMA and PAI-1, and increased E-cadherin in TGF-beta1 treated proximal tubular epithelial cell HK-2 cells. Curcumin 14-22 cadherin 1 Homo sapiens 113-123 24236784-7 2013 Curcumin reversed doxorubicin-induced morphological changes, inhibited doxorubicin-induced downregulation of E-cadherin expressions, and inhibited doxorubicin-induced upregulation of vimentin expression. Curcumin 0-8 cadherin 1 Homo sapiens 109-119 23970932-0 2013 Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Curcumin 0-8 cadherin 1 Homo sapiens 61-71 23970932-9 2013 Moreover, E-cadherin expression is upregulated by curcumin and serves as an inhibitor of EMT. Curcumin 50-58 cadherin 1 Homo sapiens 10-20 23970932-10 2013 These results suggest that curcumin executes its antimetastasis function through downregulation of Sp-1, FAK, and CD24 and by promoting E-cadherin expression in CRC cells. Curcumin 27-35 cadherin 1 Homo sapiens 136-146 20971552-6 2011 We show that Wnt inhibitors curcumin and quercetin target downstream beta-catenin activity and effectively repress HBx-mediated regulation of c-MYC and E-cadherin. Curcumin 28-36 cadherin 1 Homo sapiens 152-162 18794131-9 2008 Activation of HLJ1 by curcumin further leads to up-regulation of E-cadherin and a suppression of cancer cell invasion. Curcumin 22-30 cadherin 1 Homo sapiens 65-75 19573523-9 2009 The expression levels of two integral proteins of Wnt signaling, GSK3beta and E-cadherin were also altered by curcumin treatment. Curcumin 110-118 cadherin 1 Homo sapiens 78-88 18794131-10 2008 Our results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression. Curcumin 22-30 cadherin 1 Homo sapiens 157-167 12466962-9 2002 The curcumin treatment also induced caspase-3-mediated degradation of cell-cell adhesion proteins beta-catenin, E-cadherin and APC, which were linked with apoptosis, and this degradation was prevented with the caspase-3 inhibitor. Curcumin 4-12 cadherin 1 Homo sapiens 112-122 17569210-9 2007 Curcumin was found to suppress the expression of cyclooxygenase-2, vascular endothelial growth factor, and intercellular adhesion molecule- and elevated the expression of antimetastatic proteins, the tissue inhibitor of metalloproteases-2, nonmetastatic gene 23, and Ecadherin. Curcumin 0-8 cadherin 1 Homo sapiens 267-276 34357837-9 2021 In vitro, curcumin attenuated cell proliferation, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in BPH-1 cells. Curcumin 10-18 cadherin 1 Homo sapiens 130-140 33000266-12 2020 Additionally, the mRNA and protein levels of apoptosis-associated proteins (Fas, FADD, caspase-8 and caspase-3) and E-cadherin in HCT-116 cells were upregulated following treatment with curcumin in a dose-dependent manner. Curcumin 186-194 cadherin 1 Homo sapiens 116-126 34357837-10 2021 Furthermore, BAMBI knockdown reversed the expression of vimentin and E-cadherin induced by curcumin. Curcumin 91-99 cadherin 1 Homo sapiens 69-79 34641401-5 2021 When synergy was observed, for example with curcumin and irinotecan, this was unrelated to MET induction, as assessed by changes in E-cadherin and vimentin expression. Curcumin 44-52 cadherin 1 Homo sapiens 132-142 35487055-9 2022 Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes. Curcumin 59-67 cadherin 1 Homo sapiens 309-319