PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34641401-5 2021 When synergy was observed, for example with curcumin and irinotecan, this was unrelated to MET induction, as assessed by changes in E-cadherin and vimentin expression. Curcumin 44-52 vimentin Homo sapiens 147-155 34357837-9 2021 In vitro, curcumin attenuated cell proliferation, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in BPH-1 cells. Curcumin 10-18 vimentin Homo sapiens 79-87 34357837-10 2021 Furthermore, BAMBI knockdown reversed the expression of vimentin and E-cadherin induced by curcumin. Curcumin 91-99 vimentin Homo sapiens 56-64 31511210-6 2019 In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin. Curcumin 30-38 vimentin Homo sapiens 203-211 31854220-5 2020 The expression of MAPK, NF-kappaB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting.Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg). Curcumin 153-161 vimentin Homo sapiens 50-58 31854220-9 2020 Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target. Curcumin 0-8 vimentin Homo sapiens 38-46 31854220-9 2020 Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target. Curcumin 103-111 vimentin Homo sapiens 38-46 31854220-9 2020 Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target. Curcumin 217-225 vimentin Homo sapiens 38-46 32893845-11 2020 The expression levels of N-cadherin, Vimentin, Wnt3a, Snail1, and Twist, as well as the nuclear translocation levels of ss-catenin, were reduced in a curcumin concentration-dependent manner. Curcumin 150-158 vimentin Homo sapiens 37-45 32391111-10 2020 Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, an ERK. Curcumin 13-21 vimentin Homo sapiens 96-104 32377752-16 2020 In addition, curcumin and IL-6-neutralizing antibody treatment suppressed PSC-CM-modulated pancreatic cancer invasion, EMT and the changes in the expression of E-cadherin, vimentin and matrix metallopeptidase-9. Curcumin 13-21 vimentin Homo sapiens 172-180 31436299-9 2019 The results demonstrated a significant decrease in EMT following exposure to 20 microM curcumin for 72 h. This finding was supported by a decrease in the protein expression levels of N-cadherin, Vimentin and Slug. Curcumin 87-95 vimentin Homo sapiens 195-203 29139094-13 2018 CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2. Curcumin 12-20 vimentin Homo sapiens 168-171 29801408-8 2018 Theresults showed that administration of curcumin in all the dose administered were incapable improving the expressionsof vimentin, TGF-beta1 and E-cadherin. Curcumin 41-49 vimentin Homo sapiens 122-130 31005718-12 2019 Moreover, curcumin down-regulated the mRNA expression of Vimentin, Fibronectin, and beta-catenin, and up-regulated E-cadherin mRNA expression levels. Curcumin 10-18 vimentin Homo sapiens 57-65 29420338-9 2018 After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated. Curcumin 6-14 vimentin Homo sapiens 180-188 29312505-4 2017 Our results showed that curcumin attenuated the high expression levels of fibroblast proteins (alpha-SMA & Vimentin) in GC-MSCs. Curcumin 24-32 vimentin Homo sapiens 111-119 27829579-7 2017 When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin. Curcumin 47-55 vimentin Homo sapiens 164-172 27829579-7 2017 When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin. Curcumin 66-74 vimentin Homo sapiens 164-172 27082017-7 2016 Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB. Curcumin 23-31 vimentin Homo sapiens 179-187 26893768-6 2016 Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, extracellular signal-regulated kinase and Snail. Curcumin 13-21 vimentin Homo sapiens 96-104 24325063-7 2013 Intervention by curcumin significantly inhibited the proliferation and migration of hypoxic HepG2 cells, and expressions of HIF-1alpha and vimentin decreased, and the expression of E-cadherin was up-regulated, showing statistical difference when compared with those of the CoCl2 group (P < 0.05). Curcumin 16-24 vimentin Homo sapiens 139-147 27423629-6 2016 Our data also showed that curcumin inhibits oxidative stress-induced cytoskeleton disarrangement, and impedes the activation of astrocytes by inhibiting upregulation of GFAP, vimentin and Prdx6. Curcumin 26-34 vimentin Homo sapiens 175-183 24236784-7 2013 Curcumin reversed doxorubicin-induced morphological changes, inhibited doxorubicin-induced downregulation of E-cadherin expressions, and inhibited doxorubicin-induced upregulation of vimentin expression. Curcumin 0-8 vimentin Homo sapiens 183-191 26770672-3 2013 Curcumin activated caspase-3 and the cleavage of the two cytoskeletal proteins lamin B1 and vimentin. Curcumin 0-8 vimentin Homo sapiens 92-100 23563640-8 2013 The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P<0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P<0.01, respectively). Curcumin 93-101 vimentin Homo sapiens 279-287 23563640-8 2013 The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P<0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P<0.01, respectively). Curcumin 93-101 vimentin Homo sapiens 279-287