PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26100249-0 2015 Curcumin inhibits human cytomegalovirus by downregulating heat shock protein 90. Curcumin 0-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 58-79 33824458-0 2022 C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function. Curcumin 15-23 heat shock protein 90 alpha family class A member 1 Homo sapiens 138-143 33824458-4 2022 Compared to curcumin, a novel derivative of curcumin, 3,5-(E)-Bis(3-methoxy-4-hydroxybenzal)-4-piperidinone hydrochloride (C0818) that is more potent in Hsp90 inhibition and antitumor activity. Curcumin 44-52 heat shock protein 90 alpha family class A member 1 Homo sapiens 153-158 31820701-0 2021 Network Pharmacology Approach uncovering Pathways involved in targeting Hsp90 through Curcumin and Epigallocatechin to control Inflammation. Curcumin 86-94 heat shock protein 90 alpha family class A member 1 Homo sapiens 72-77 31820701-4 2021 Curcumin and EGC were also found to bind -N and -C terminal domain of Hsp90 respectively. Curcumin 0-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 70-75 31820701-6 2021 Hsp90 associated gene targets of Curcumin and EGC were collected from databases, and gene ontology studies were done. Curcumin 33-41 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 31820701-10 2021 Main proteins involved were identified as key regulators in Pkcdelta-Nrf2 and Tlr4 pathway for controlling expression of Hsp90 from Curcumin and EGC in inflammation. Curcumin 132-140 heat shock protein 90 alpha family class A member 1 Homo sapiens 121-126 31820701-11 2021 Docking was performed on main proteins, Hsp90, Pkcdelta and Tlr4 with Curcumin and EGC, significant binding energy was obtained for docked complexes. Curcumin 70-78 heat shock protein 90 alpha family class A member 1 Homo sapiens 40-45 31820701-13 2021 Present study is an attempt to unravel common pathways mediated in intervention of Curcumin and EGC for suppression of Hsp90 associated with inflammation. Curcumin 83-91 heat shock protein 90 alpha family class A member 1 Homo sapiens 119-124 32993709-0 2020 Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy. Curcumin 0-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 34-39 29219946-0 2018 C1206, a novel curcumin derivative, potently inhibits Hsp90 and human chronic myeloid leukemia cells in vitro. Curcumin 15-23 heat shock protein 90 alpha family class A member 1 Homo sapiens 54-59 29219946-1 2018 4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action. Curcumin 26-34 heat shock protein 90 alpha family class A member 1 Homo sapiens 126-147 29219946-1 2018 4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action. Curcumin 26-34 heat shock protein 90 alpha family class A member 1 Homo sapiens 149-154 29219946-1 2018 4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action. Curcumin 66-74 heat shock protein 90 alpha family class A member 1 Homo sapiens 126-147 29219946-1 2018 4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action. Curcumin 66-74 heat shock protein 90 alpha family class A member 1 Homo sapiens 149-154 33457406-4 2020 Under simulated hypoxic conditions, curcumin combined with Glu-GNPs can significantly improve the ROS level of MCF-7 and MDA-MB-231 mammospheres; reduce the expression of HIF-1alpha and HSP90, thereby inhibiting the tumor cells" own stress ability; promote the apoptosis of tumor stem cells; and enhance the sensitivity of radiotherapy. Curcumin 36-44 heat shock protein 90 alpha family class A member 1 Homo sapiens 186-191 32222339-4 2020 Herein we report a series of compounds by molecular hybridization PARP-1 inhibitor Olaparib (Ola) with HSP90 inhibitor C0817 (one curcumin derivative). Curcumin 130-138 heat shock protein 90 alpha family class A member 1 Homo sapiens 103-108 31136038-4 2019 Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Curcumin 0-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 104-109 30463061-0 2018 Curcumin Protects an SH-SY5Y Cell Model of Parkinson"s Disease Against Toxic Injury by Regulating HSP90. Curcumin 0-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 98-103 26100249-2 2015 The present study reported that the pharmacogenomics of curcumin are similar to that of the antiviral drug, geldanamycin, which targets heat shock protein 90 (Hsp90). Curcumin 56-64 heat shock protein 90 alpha family class A member 1 Homo sapiens 136-157 26100249-2 2015 The present study reported that the pharmacogenomics of curcumin are similar to that of the antiviral drug, geldanamycin, which targets heat shock protein 90 (Hsp90). Curcumin 56-64 heat shock protein 90 alpha family class A member 1 Homo sapiens 159-164 26100249-4 2015 Molecular docking simulation analysis revealed that curcumin fit well in the binding pocket of Hsp90, with hydrogen bonds, hydrophobic interactions and conjugation to maintain adhesion. Curcumin 52-60 heat shock protein 90 alpha family class A member 1 Homo sapiens 95-100 26100249-5 2015 Consistently, HCMV infection of human embryonic lung fibroblast cells resulted in increased expression of Hsp90alpha, which was significantly inhibited by treatment with curcumin. Curcumin 170-178 heat shock protein 90 alpha family class A member 1 Homo sapiens 106-116 26100249-6 2015 These findings suggested that targeting Hsp90 contributed to the anti-HCMV activity of curcumin. Curcumin 87-95 heat shock protein 90 alpha family class A member 1 Homo sapiens 40-45 25497868-7 2015 Treatment with UBS109, EF31 or curcumin inhibited HSP90, NF-kappaB, and HIF-1alpha transcription in PC cell lines. Curcumin 31-39 heat shock protein 90 alpha family class A member 1 Homo sapiens 50-55 25497868-9 2015 Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts. Curcumin 48-56 heat shock protein 90 alpha family class A member 1 Homo sapiens 124-129 25272063-7 2014 Overexpression of HSPs (27, 70, 90), HSF1, and HDAC6 in leukemia cells were down-regulated by curcumin, and the effects on HSPs 27and 70 were less than that on HSP 90. Curcumin 94-102 heat shock protein 90 alpha family class A member 1 Homo sapiens 160-166 24211270-10 2014 Additionally, treatment with a chemopreventive compound, curcumin, induced HO-1 expression accompanied with reduction of HSP90 client protein expression. Curcumin 57-65 heat shock protein 90 alpha family class A member 1 Homo sapiens 121-126 23294827-7 2013 Peptides pulled down from this reaction were sequenced and it was determined that biotinylated curcumin bound hsp70, hsp90, 3-phosphoglycerate dehydrogenase, and a beta-actin variant. Curcumin 95-103 heat shock protein 90 alpha family class A member 1 Homo sapiens 117-122 20039095-0 2010 The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. Curcumin 85-93 heat shock protein 90 alpha family class A member 1 Homo sapiens 109-114 20039095-2 2010 In this study, we observed that curcumin inhibited Hsp90 activity causing depletion of client proteins implicated in survival pathways. Curcumin 32-40 heat shock protein 90 alpha family class A member 1 Homo sapiens 51-56 20039095-3 2010 Based on this observation, this study was designed to investigate the cellular effects of curcumin combination with the pan-HDAC inhibitors, vorinostat and panobinostat, which induce hyperacetylation of Hsp90, resulting in inhibition of its chaperone function. Curcumin 90-98 heat shock protein 90 alpha family class A member 1 Homo sapiens 203-208 16723087-0 2006 Down-regulation of p210(bcr/abl) by curcumin involves disrupting molecular chaperone functions of Hsp90. Curcumin 36-44 heat shock protein 90 alpha family class A member 1 Homo sapiens 98-103 16804017-6 2006 Furthermore, the preincubation of human keratinocytes at 43 degrees C for 1 h, followed by 24-h treatment with 3 microM curcumin, led to an increase in heat-shock protein (hsp70 and hsp90) levels by 24% and 19%, respectively, and the effect was sustained at concentrations up to 10 microM. Curcumin 120-128 heat shock protein 90 alpha family class A member 1 Homo sapiens 182-187 19751963-0 2010 Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Curcumin 0-8 heat shock protein 90 alpha family class A member 1 Homo sapiens 73-78 19028451-5 2009 IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190. Curcumin 85-93 heat shock protein 90 alpha family class A member 1 Homo sapiens 34-39