PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	cyclin dependent kinase inhibitor 2A	Homo sapiens	205-211	
26338965-9	2015	Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts.	Curcumin	67-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	103-106	
26338965-9	2015	Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts.	Curcumin	67-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	107-112	
26338965-9	2015	Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts.	Curcumin	67-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	121-127	
23730211-0	2013	Curcumin triggers p16-dependent senescence in active breast cancer-associated fibroblasts and suppresses their paracrine procarcinogenic effects.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	18-21	
23730211-4	2013	We have shown that curcumin treatment upregulates p16(INK4A) and other tumor suppressor proteins while inactivates the JAK2/STAT3 pathway.	Curcumin	19-27	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53	
23730211-4	2013	We have shown that curcumin treatment upregulates p16(INK4A) and other tumor suppressor proteins while inactivates the JAK2/STAT3 pathway.	Curcumin	19-27	cyclin dependent kinase inhibitor 2A	Homo sapiens	54-59	
23730211-9	2013	Importantly, this curcumin-related senescence was p16(INK4A)-dependent and occurred with no associated inflammatory secretory phenotype.	Curcumin	18-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53	
23730211-9	2013	Importantly, this curcumin-related senescence was p16(INK4A)-dependent and occurred with no associated inflammatory secretory phenotype.	Curcumin	18-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	54-59	
21896275-8	2011	p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b).	Curcumin	28-36	cyclin dependent kinase inhibitor 2A	Homo sapiens	66-69	
21896275-8	2011	p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b).	Curcumin	28-36	cyclin dependent kinase inhibitor 2A	Homo sapiens	70-75	
30149755-0	2018	Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	57-60	
30149755-9	2018	Curcumin induces the downregulation of miR-7641 and subsequent upregulation of p16 which is a target of miR-7641 at the post-transcriptional level, which leads to the decreased invasion and increased apoptosis of bladder cancer cells.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	79-82	
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	cyclin dependent kinase inhibitor 2A	Homo sapiens	212-215	
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	76-79	
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	81-86