PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24316441-3 2014 In this study, we demonstrated that curcumin, a natural product which functions as an anti-inflammatory agent, inhibited the activation of signal transducer and activator of transcription-3 and NF-kappa B in the injured spinal cord. Curcumin 36-44 signal transducer and activator of transcription 3 Mus musculus 139-189 24819716-3 2014 FLLL31 is a newly developed compound based on the herbal medicine curcumin, which specifically suppresses the activation of STAT3. Curcumin 66-74 signal transducer and activator of transcription 3 Mus musculus 124-129 24645646-14 2014 Moreover, curcumin significantly reduced the expression of NF-kappaB p65 in nuclei and phospho-STAT3 (p-STAT3) in cytosols and nuclei. Curcumin 10-18 signal transducer and activator of transcription 3 Mus musculus 95-100 24645646-14 2014 Moreover, curcumin significantly reduced the expression of NF-kappaB p65 in nuclei and phospho-STAT3 (p-STAT3) in cytosols and nuclei. Curcumin 10-18 signal transducer and activator of transcription 3 Mus musculus 104-109 24645646-15 2014 CONCLUSIONS: This study indicates that curcumin ameliorates the depressed MFG-E8 expression and the attenuated phagocytic ability of EMF-exposed N9 cells, which is attributable to the inhibition of the pro-inflammatory response through the NF-kappaB and STAT3 pathways. Curcumin 39-47 signal transducer and activator of transcription 3 Mus musculus 254-259 25011972-0 2014 [Effect of curcumin on the expression of p-STAT3 and IkappaB in db/db mice]. Curcumin 11-19 signal transducer and activator of transcription 3 Mus musculus 43-48 25011972-10 2014 Compared with the db/db mice, curcumin significantly decreased the urinary albumin, inhibited the phosphorylation of STAT3 and the degradation of IkappaB, and reduced the expression of collagen IV and FN in the kidney. Curcumin 30-38 signal transducer and activator of transcription 3 Mus musculus 117-122 25011972-11 2014 CONCLUSION: Curcumin can obviously decrease albuminuria and attenuate glomerular sclerosis in diabetic db/db mice by inhibiting phosphorylation of STAT3 and degradation of IkappaB. Curcumin 12-20 signal transducer and activator of transcription 3 Mus musculus 147-152 24036260-9 2013 Findings in both in vitro and in vivo mechanistic studies are consistent with the supposition that the presently described liposomal formulation of curcumin inhibits tumor growth by blocking VEGF-induced STAT3 phosphorylation in tumor endothelium. Curcumin 148-156 signal transducer and activator of transcription 3 Mus musculus 204-209 23856612-0 2013 Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 85-90 23856612-2 2013 The purpose of the study was to investigate whether curcumin could exert its therapeutic effects in experimental colitis by inhibiting STAT3 pathway. Curcumin 52-60 signal transducer and activator of transcription 3 Mus musculus 135-140 23856612-10 2013 CONCLUSION: Curcumin exerts beneficial effects in experimental colitis by the suppression of STAT3 pathway, which may therefore provide a better understanding of the mechanism of action for curcumin in treating colitis. Curcumin 12-20 signal transducer and activator of transcription 3 Mus musculus 93-98 23856612-10 2013 CONCLUSION: Curcumin exerts beneficial effects in experimental colitis by the suppression of STAT3 pathway, which may therefore provide a better understanding of the mechanism of action for curcumin in treating colitis. Curcumin 190-198 signal transducer and activator of transcription 3 Mus musculus 93-98 25337545-0 2013 Curcumin Inhibits STAT3 Signaling in the Colon of Dextran Sulfate Sodium-treated Mice. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 18-23 25337545-5 2013 Our study revealed that administration of curcumin significantly attenuated the severity of DSS-induced colitis and STAT3 signaling in mouse colon. Curcumin 42-50 signal transducer and activator of transcription 3 Mus musculus 116-121 22156994-8 2012 In-vitro studies with curcuminoid complex demonstrated that the activity of Stat3 in both normal bronchoepithelial cells and lung cancer-derived cells is sensitive to curcumin exposure. Curcumin 22-30 signal transducer and activator of transcription 3 Mus musculus 76-81 22156994-0 2012 Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 19-24 22751848-7 2012 The induction of signal transducer and activator of transcription 3 phosphorylation by curcumin resulted in the downregulation of the suppressor of cytokine signaling 3 in the liver of obese mice. Curcumin 87-95 signal transducer and activator of transcription 3 Mus musculus 17-67 22156994-9 2012 In a dose-dependent manner, curcumin treatment resulted in significant suppression of Stat3 phosphorylation and reduction in the proliferative capacity of both cell types. Curcumin 28-36 signal transducer and activator of transcription 3 Mus musculus 86-91 22156994-10 2012 In the preclinical trial with rodent models, curcumin reduced Stat3-P and the proliferative markers CycD1 and Mcm2 in mice lung tissues in vivo. Curcumin 45-53 signal transducer and activator of transcription 3 Mus musculus 62-67 22156994-11 2012 These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium. Curcumin 107-115 signal transducer and activator of transcription 3 Mus musculus 72-77 22156994-11 2012 These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium. Curcumin 107-115 signal transducer and activator of transcription 3 Mus musculus 228-233 22156994-11 2012 These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium. Curcumin 295-303 signal transducer and activator of transcription 3 Mus musculus 72-77 22156994-11 2012 These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium. Curcumin 295-303 signal transducer and activator of transcription 3 Mus musculus 228-233 21345977-9 2011 Importantly, Pkd1-deletion mice that were treated with curcumin and killed at an early stage of PKD displayed improved renal histology and reduced STAT3 activation, proliferation index, cystic index, and kidney weight/body weight ratios. Curcumin 55-63 signal transducer and activator of transcription 3 Mus musculus 147-152 20513444-8 2010 Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities. Curcumin 63-71 signal transducer and activator of transcription 3 Mus musculus 94-99 21138870-0 2010 Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway. Curcumin 8-16 signal transducer and activator of transcription 3 Mus musculus 97-102 21138870-6 2010 RESULTS: In vitro, curcumin inhibited JAK1,2/STAT3 tyrosine-phosphorylation in a dose-dependent fashion in murine glioma cell lines. Curcumin 19-27 signal transducer and activator of transcription 3 Mus musculus 45-50 21138870-7 2010 Real-time RT-PCR revealed that curcumin downregulated transcription of the STAT3 target genes c-Myc, MMP-9, Snail, and Twist, and of the proliferation marker Ki67. Curcumin 31-39 signal transducer and activator of transcription 3 Mus musculus 75-80 20513444-8 2010 Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities. Curcumin 63-71 signal transducer and activator of transcription 3 Mus musculus 121-126 34931590-7 2022 In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue. Curcumin 13-21 signal transducer and activator of transcription 3 Mus musculus 93-98 20169331-9 2010 STAT3 inhibitors, including curcumin, AG490 and a peptide (PpYLKTK), reduced hepcidin1 mRNA expression even when cells were additionally exposed to IL-6. Curcumin 28-36 signal transducer and activator of transcription 3 Mus musculus 0-5 12055272-7 2002 In vitro treatment of activated T cells with curcumin inhibited IL-12-induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2, and STAT3 and STAT4 transcription factors. Curcumin 45-53 signal transducer and activator of transcription 3 Mus musculus 145-150 34931590-7 2022 In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue. Curcumin 13-21 signal transducer and activator of transcription 3 Mus musculus 199-204 34976224-11 2022 Curcumin alleviated LPS-mediated sepsis by suppressing the activities of mitochondrial STAT3 and NF-kappaB. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 87-92 34233590-6 2021 In vivo studies have shown that curcumin significantly reduces the mortality of mice and control the occurrence and size of liver tumors by inhibiting the IL-6/STAT3 signaling pathway. Curcumin 32-40 signal transducer and activator of transcription 3 Mus musculus 160-165 33982329-0 2021 A curcumin analogue GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circZNF83/miR-324-5p/CDK16 axis. Curcumin 2-10 signal transducer and activator of transcription 3 Mus musculus 111-116 32556081-0 2020 Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 66-71 32615888-0 2020 Curcumin attenuates inflammation and cell apoptosis through regulating NF-kappaB and JAK2/STAT3 signaling pathway against acute kidney injury. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 90-95 32615888-5 2020 Western blot analysis indicated that Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3, p-65-NF-kappaB and cell apoptosis pathways were activated by LPS but suppressed by Curcumin. Curcumin 200-208 signal transducer and activator of transcription 3 Mus musculus 58-115 32615888-7 2020 Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI. Curcumin 27-35 signal transducer and activator of transcription 3 Mus musculus 110-115 32615888-8 2020 The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI. Curcumin 32-40 signal transducer and activator of transcription 3 Mus musculus 95-100 32615888-8 2020 The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI. Curcumin 139-147 signal transducer and activator of transcription 3 Mus musculus 95-100 33006786-0 2020 Enhanced anti-tumor effects of the PD-1 blockade combined with a highly absorptive form of curcumin targeting STAT3. Curcumin 91-99 signal transducer and activator of transcription 3 Mus musculus 110-115 33006786-9 2020 These results indicate that curcumin augments the induction of tumor antigen-specific T cells by restoring the T cell stimulatory activity of DCs targeting activated STAT3 in both cancer cells and immune cells. Curcumin 28-36 signal transducer and activator of transcription 3 Mus musculus 166-171 32613952-6 2020 A docking study was performed and proved the strong affinity between curcumin and the proteins of STAT3, FASN, and AKT. Curcumin 69-77 signal transducer and activator of transcription 3 Mus musculus 98-103 32572733-9 2020 Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 97-103 31252572-6 2019 Consistent with these data, curcumin stimulation upregulates the expression of Suppressors of cytokine signaling (SOCS)-1, whereas phosphorylation of the JAK2 and STAT3 was reduced. Curcumin 28-36 signal transducer and activator of transcription 3 Mus musculus 163-168 29629345-6 2018 Results: Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-kappaB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase. Curcumin 27-35 signal transducer and activator of transcription 3 Mus musculus 133-138 30668131-3 2019 The combined application of curcumin (CUR) and celecoxib (CXB) has been proven to exert a synergistic antitumor effect via inhibiting the activation of NF-kappaB and STAT3. Curcumin 28-36 signal transducer and activator of transcription 3 Mus musculus 166-171 30518397-0 2018 The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma. Curcumin 23-31 signal transducer and activator of transcription 3 Mus musculus 65-70 30518397-3 2018 METHODS: Luciferase assay and immunoblotting were performed to examine whether curcumin suppressed STAT3 signaling. Curcumin 79-87 signal transducer and activator of transcription 3 Mus musculus 99-104 30518397-11 2018 RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells. Curcumin 32-40 signal transducer and activator of transcription 3 Mus musculus 51-56 30518397-11 2018 RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells. Curcumin 32-40 signal transducer and activator of transcription 3 Mus musculus 93-98 30518397-13 2018 Furthermore, curcumin preferentially blocked the growth of primary ESCC-derived xenografts that harbored activated STAT3. Curcumin 13-21 signal transducer and activator of transcription 3 Mus musculus 115-120 30518397-14 2018 CONCLUSIONS: Curcumin is able to exert anti-tumor action through inhibiting the STAT3 signaling pathway. Curcumin 13-21 signal transducer and activator of transcription 3 Mus musculus 80-85 30518397-15 2018 Giving its wide use in traditional medicines with low toxicity and few adverse reactions, it is conceivable that curcumin might be further explored as a unique STAT3 inhibitor for anti-cancer therapies. Curcumin 113-121 signal transducer and activator of transcription 3 Mus musculus 160-165 29629345-8 2018 Conclusions: Intragastric administration of curcumin inhibited the experimentally induced murine colitis, which was associated with inhibition of pro-inflammatory signaling mediated by NF-kappaB and STAT3. Curcumin 44-52 signal transducer and activator of transcription 3 Mus musculus 199-204 26817244-7 2016 The detailed mechanism of these compounds showed that triptolide enhanced calcium restoration, curcumin inhibited ERK & p-STAT3 pathways, ginkolide B inhibited Ras/MAPK pathway, and steviol activated AMPK, which inhibited CFTR channel and mTOR pathway in cell and mouse models of PKD. Curcumin 95-103 signal transducer and activator of transcription 3 Mus musculus 126-131 28880787-12 2018 STAT3 inhibition with micellar curcumin also suppressed postablation stimulation of distant tumor growth, proliferation, and microvascular density (P < .01). Curcumin 31-39 signal transducer and activator of transcription 3 Mus musculus 0-5 28639178-2 2018 Curcumin was encapsulated in DOTAP-based cationic liposomes and then complexed with STAT3 siRNA. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 84-89 28639178-4 2018 The cell viability studies in B16F10 mouse melanoma cells have shown that the co-delivery of curcumin and STAT3 siRNA significantly (p < 0.05) inhibited the cancer cell growth compared with either liposomal curcumin or STAT3 siRNA alone. Curcumin 93-101 signal transducer and activator of transcription 3 Mus musculus 222-227 28639178-7 2018 Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p < 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone. Curcumin 25-33 signal transducer and activator of transcription 3 Mus musculus 214-219 28639178-7 2018 Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p < 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone. Curcumin 202-210 signal transducer and activator of transcription 3 Mus musculus 38-43 28639178-8 2018 Furthermore, the iontophoretic administration of curcumin-loaded liposome-siRNA complex showed similar effectiveness in inhibiting tumor progression and STAT3 protein suppression compared with intratumoral administration. Curcumin 49-57 signal transducer and activator of transcription 3 Mus musculus 153-158 28967875-9 2017 Here, we found that curcumin combination with EGCG attenuated the tumor CM-induced transition of NECs toward TECs by inhibiting JAK/STAT3 signaling pathway. Curcumin 20-28 signal transducer and activator of transcription 3 Mus musculus 132-137 26815506-0 2016 Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 69-74 28967875-0 2017 Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway. Curcumin 12-20 signal transducer and activator of transcription 3 Mus musculus 131-136 28848967-14 2017 The expression of DEC1, HIF-1alpha, STAT3 and VEGF in tumor tissues was down-regulated after curcumin treatment. Curcumin 93-101 signal transducer and activator of transcription 3 Mus musculus 36-41 28848967-15 2017 Our results indicate that curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large amount of cytokines, and down-regulating the DEC1, HIF-1alpha, VEGF and STAT3 signal transduction pathways. Curcumin 26-34 signal transducer and activator of transcription 3 Mus musculus 240-245 29254150-0 2017 Novel allylated monocarbonyl analogs of curcumin induce mitotic arrest and apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and inhibition of STAT3. Curcumin 40-48 signal transducer and activator of transcription 3 Mus musculus 168-173 25331984-0 2015 Inhibition of beta-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo. Curcumin 44-52 signal transducer and activator of transcription 3 Mus musculus 31-36 25331984-5 2015 A newly synthesized curcumin analog has inhibitory potential against beta-catenin and STAT3. Curcumin 20-28 signal transducer and activator of transcription 3 Mus musculus 86-91 25331984-11 2015 CONCLUSION: beta-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits beta-catenin and STAT3. Curcumin 85-93 signal transducer and activator of transcription 3 Mus musculus 29-34 25331984-11 2015 CONCLUSION: beta-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits beta-catenin and STAT3. Curcumin 85-93 signal transducer and activator of transcription 3 Mus musculus 146-151 25822711-4 2015 Curcumin sustained the LIF independent self-renewal of mESCs and induced pluripotent stem cells (miPSCs) in a STAT3 activity dependent manner. Curcumin 0-8 signal transducer and activator of transcription 3 Mus musculus 110-115