PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33247374-0 2022 Curcumin Improves Human Umbilical Cord-Derived Mesenchymal Stem Cell Survival via ERK1/2 Signaling and Promotes Motor Outcomes After Spinal Cord Injury. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 82-88 33914984-6 2021 RESULTS: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family (MAPK), extracellular signal-regulated protein kinase (ERK1/2), activator protein-1 (AP-1), and nuclear factor kappa B (NF-kB) are the main mechanisms associated with the anti-inflammatory function of curcumin in RA. Curcumin 57-65 mitogen-activated protein kinase 3 Homo sapiens 202-206 33914984-6 2021 RESULTS: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family (MAPK), extracellular signal-regulated protein kinase (ERK1/2), activator protein-1 (AP-1), and nuclear factor kappa B (NF-kB) are the main mechanisms associated with the anti-inflammatory function of curcumin in RA. Curcumin 57-65 mitogen-activated protein kinase 3 Homo sapiens 256-262 32934683-7 2020 Additionally, curcumin and rAd-p53 were demonstrated to regulate the activation of mitogen-activated protein kinases (MAPKs) ERK1/2, p38 MAPK and JNK. Curcumin 14-22 mitogen-activated protein kinase 3 Homo sapiens 125-131 30770549-0 2019 Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2-mediated activation of the Nrf2/HO-1 pathway. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 82-88 32020664-9 2020 In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation. Curcumin 83-86 mitogen-activated protein kinase 3 Homo sapiens 244-287 32020664-9 2020 In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation. Curcumin 83-86 mitogen-activated protein kinase 3 Homo sapiens 289-295 31798724-2 2019 The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and the involvement of ERK1/2 and/or p53 activation in this process. Curcumin 43-51 mitogen-activated protein kinase 3 Homo sapiens 273-279 31798724-2 2019 The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and the involvement of ERK1/2 and/or p53 activation in this process. Curcumin 53-56 mitogen-activated protein kinase 3 Homo sapiens 273-279 31798724-7 2019 ERK1/2 activation status was essential for both cell processes, proliferation and apoptosis induced by CisPt and/or CRM treatment on squamous cell carcinoma cells. Curcumin 116-119 mitogen-activated protein kinase 3 Homo sapiens 0-6 31798724-8 2019 Our data suggest that p53 phosphorylation in the apoptotic process induced by CRM treatment might require the involvement of ERK1/2. Curcumin 78-81 mitogen-activated protein kinase 3 Homo sapiens 125-131 31798724-10 2019 Moreover, in both tumor cell lines our results support the involvement of p53 phosphorylation-ERK1/2 activation-dependent in the apoptosis induced by combined treatments (CisPt and CRM). Curcumin 181-184 mitogen-activated protein kinase 3 Homo sapiens 94-100 31798724-11 2019 The use of CRM as adjuvant could increase the efficiency of chemotherapy by modulating cellular activation processes of ERK1/2 signaling pathways. Curcumin 11-14 mitogen-activated protein kinase 3 Homo sapiens 120-126 31703057-5 2019 Curcumin, a specific activator of extracellular signal regulated kinases (ERK1/2), or PD98059, a specific inhibitor of ERK1/2, was used to activate or block the ERK1/2 pathway, respectively. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 74-80 31703057-9 2019 Interestingly, the inhibitory effect of TRIM48 overexpression on human GBM cell growth and the inactivation of ERK1/2 were significantly alleviated with additional curcumin treatment, while it the promoted the effect of siTRIM48 on human GBM cell growth, and the activation of ERK1/2 was significantly alleviated with additional PD98059 treatment. Curcumin 164-172 mitogen-activated protein kinase 3 Homo sapiens 111-117 31703057-9 2019 Interestingly, the inhibitory effect of TRIM48 overexpression on human GBM cell growth and the inactivation of ERK1/2 were significantly alleviated with additional curcumin treatment, while it the promoted the effect of siTRIM48 on human GBM cell growth, and the activation of ERK1/2 was significantly alleviated with additional PD98059 treatment. Curcumin 164-172 mitogen-activated protein kinase 3 Homo sapiens 277-283 29599831-8 2018 Additionally, curcumin significantly inhibited the expression of p-Akt, p-Erk1/2, HIF-1alpha and VEGF in hypoxia-induced IGF-1R knockout HepG2 cells. Curcumin 14-22 mitogen-activated protein kinase 3 Homo sapiens 74-80 31682378-3 2017 RESULTS: Compared with the effects of either agent alone, the combination of curcumin and gefitinib had a stronger suppressive effect on proliferation and the clonogenic capacity (P < 0.05), and showed an increased ability to promote apoptosis (P < 0.05) and reduce p38, ERK1/2, and AKT phosphorylation (P < 0.05). Curcumin 77-85 mitogen-activated protein kinase 3 Homo sapiens 277-283 28930270-8 2017 Increase in ERK1/2 phosphorylation in response to leptin was reduced by the addition of quercetin, curcumin and EGCG. Curcumin 99-107 mitogen-activated protein kinase 3 Homo sapiens 12-18 28430129-0 2017 Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 63-69 28430129-9 2017 Curcumin can increase the expression of phosphorylated extracellular signal-regulated kinases 1/2 (ERK1/2), autophagy marker light chain 3 (LC3)-II, and Beclin-1 in chondrocytes. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 99-105 28430129-11 2017 Our results suggest that curcumin suppresses apoptosis and inflammatory signaling through its actions on the ERK1/2-induced autophagy in chondrocytes. Curcumin 25-33 mitogen-activated protein kinase 3 Homo sapiens 109-115 28697568-7 2017 The effect of Abeta42 can be mimicked by PD98059 (an inhibitor of ERK1/2) and blocked by curcumin (an activator of MEK), which reveals Abeta-involved influence is via the decreased phosphorylation of MAPK-ERK1/2. Curcumin 89-97 mitogen-activated protein kinase 3 Homo sapiens 200-204 28697568-7 2017 The effect of Abeta42 can be mimicked by PD98059 (an inhibitor of ERK1/2) and blocked by curcumin (an activator of MEK), which reveals Abeta-involved influence is via the decreased phosphorylation of MAPK-ERK1/2. Curcumin 89-97 mitogen-activated protein kinase 3 Homo sapiens 205-211 27564099-0 2016 Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 113-119 27878252-6 2016 The ERK1/2 specific inhibitor, U0126, augmented the inhibitory effects of TMZ on the proliferation, migration and invasion of the glioma C6 cells, and the mitogen-activated protein kinase kinase/ERK pathway activator, curcumin, attenuated the inhibitory effects of TMZ on the proliferation and motility of the glioma C6 cells. Curcumin 218-226 mitogen-activated protein kinase 3 Homo sapiens 4-10 27580989-0 2016 Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 115-121 27580989-0 2016 Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 135-139 27580989-9 2016 The ERK1/2 and SAPK/JNK and their downstream molecules including P90RSK and c-Jun, respectively, were activated by curcumin. Curcumin 115-123 mitogen-activated protein kinase 3 Homo sapiens 4-10 27580989-10 2016 Moreover, pharmacological inhibitors of ERK1/2 (U0126) and SAPK/JNK (SP600125) suppressed ERK1/2 and SAPK/JNK activation respectively, and blockage of P38 MAPK by its inhibitor (SB203580) had a synergistic effect with curcumin. Curcumin 218-226 mitogen-activated protein kinase 3 Homo sapiens 40-46 27580989-11 2016 These results indicate that curcumin acts as a novel chemotherapeutic agent on human placental choriocarcinoma cells via activation of ERK1/2 and SAPK/JNK signal transduction cascades. Curcumin 28-36 mitogen-activated protein kinase 3 Homo sapiens 135-141 27564099-10 2016 In conclusion, co-treatment with curcumin and cisplatin synergistically induced apoptosis through ROS-mediated activation of ERK1/2 in bladder cancer. Curcumin 33-41 mitogen-activated protein kinase 3 Homo sapiens 125-131 27878252-7 2016 Additionally, the western blotting in the present study demonstrated that TMZ and U0126 decreased the expression of vascular endothelial growth factor-C (VEGF-C), and the expression level was restored by curcumin, suggesting that VEGF-C may be the downstream effector of ERK1/2. Curcumin 204-212 mitogen-activated protein kinase 3 Homo sapiens 271-277 27572279-7 2016 Curcumin inhibited the osteoclastogenic potential of PBMCs, potentially by suppressing activation of extracellular signal-regulated kinases 1 and 2, p38 and c-Jun N-terminal kinase, and inhibiting receptor activator of nuclear factor kappaB (RANK), c-Fos and nuclear factor of activated T cells (NFATc1) expression. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 101-147 27564099-5 2016 Also, caspase-3 activation and ROS production were observed in both cells treated with curcumin and cisplatin, together with upregulation of p-MEK and p-ERK1/2 signaling. Curcumin 87-95 mitogen-activated protein kinase 3 Homo sapiens 153-159 26622667-6 2015 Moreover, curcumin treatment significantly decreased the levels of the phosphorylated form of extracellular signal-regulated kinase (ERK) 1/2. Curcumin 10-18 mitogen-activated protein kinase 3 Homo sapiens 94-141 26776764-0 2016 Curcumin reverses benzidine-induced cell proliferation by suppressing ERK1/2 pathway in human bladder cancer T24 cells. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 70-76 26776764-7 2016 Treatment with ERK1/2 inhibitor U0126 or curcumin effectively abrogated benzidine-triggered cell proliferation and ERK1/2/AP-1 activation. Curcumin 41-49 mitogen-activated protein kinase 3 Homo sapiens 115-121 26776764-8 2016 These results suggested for the first time that curcumin in low concentrations played a protective role in benzidine-induced ERK1/2/AP-1 activation and proliferation of bladder cancer cells, therefore providing new insights into the pathogenesis and chemoprevention of benzidine-associated bladder cancer. Curcumin 48-56 mitogen-activated protein kinase 3 Homo sapiens 125-131 26630272-6 2015 Moreover, strong decreases in the levels of phospho-Akt and phosphor-ERK1/2 were found in PC-3 cells treated with alpha-tomatine and curcumin in combination. Curcumin 133-141 mitogen-activated protein kinase 3 Homo sapiens 69-75 26496980-8 2015 Numerous pathways, including p53, c-Jun N-terminal kinases (JNK), Akt and extracellular signal-regulated kinases (ERK)1/2 pathways were markedly altered following treatment of THP-1 cells with curcumin and naringenin. Curcumin 193-201 mitogen-activated protein kinase 3 Homo sapiens 74-121 26505786-0 2016 Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways. Curcumin 25-33 mitogen-activated protein kinase 3 Homo sapiens 136-142 26505786-9 2016 In addition, curcumin exposure along with 5-FU or DOX inhibited cell proliferation through the downregulation of EGFR-ERK1/2 signaling molecules. Curcumin 13-21 mitogen-activated protein kinase 3 Homo sapiens 118-124 25716014-11 2015 Our study demonstrated that the synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity. Curcumin 66-74 mitogen-activated protein kinase 3 Homo sapiens 227-233 25542083-6 2015 However, the most interesting observation was that both temozolomide and curcumin required ERK1/2 to induce autophagy. Curcumin 73-81 mitogen-activated protein kinase 3 Homo sapiens 91-97 25971429-0 2015 Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-kappaB/p65 and MUC1-C. BACKGROUND: Prostate cancer is one of the most common malignancies in men. Curcumin 15-23 mitogen-activated protein kinase 3 Homo sapiens 143-149 25971429-7 2015 To further explore the potential mechanism underlining this, we found that curcumin increased the phosphorylation of ERK1/2 and SAPK/JNK, which was enhanced by bicalutamide. Curcumin 75-83 mitogen-activated protein kinase 3 Homo sapiens 117-123 25971429-8 2015 In addition, curcumin reduced the protein expression of MUC1-C and NF-kappaB subunit p65, which were abrogated in the presence of the inhibitors of MEK/ERK1/2 (PD98059) and SAPK/JNK (SP60015). Curcumin 13-21 mitogen-activated protein kinase 3 Homo sapiens 152-158 25971429-11 2015 CONCLUSION: Our results show that curcumin inhibits the growth of androgen-independent prostate cancer cells through ERK1/2- and SAPK/JNK-mediated inhibition of p65, followed by reducing expression of MUC1-C protein. Curcumin 34-42 mitogen-activated protein kinase 3 Homo sapiens 117-123 25971429-13 2015 The negative feedback regulatory loop of MUC1-C to ERK1/2 and SAPK/JNK further demonstrates the role of MUC1-C that contributes to the overall responses of curcumin. Curcumin 156-164 mitogen-activated protein kinase 3 Homo sapiens 51-57 25542083-7 2015 Blocking this ERK1/2-mediated temozolomide and curcumin induced autophagy with resveratrol, a blood-brain barrier permeable drug, improved temozolomide/curcumin efficacy in brain-implanted tumors. Curcumin 47-55 mitogen-activated protein kinase 3 Homo sapiens 14-20 25542083-7 2015 Blocking this ERK1/2-mediated temozolomide and curcumin induced autophagy with resveratrol, a blood-brain barrier permeable drug, improved temozolomide/curcumin efficacy in brain-implanted tumors. Curcumin 152-160 mitogen-activated protein kinase 3 Homo sapiens 14-20 25400722-9 2014 We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3. Curcumin 25-33 mitogen-activated protein kinase 3 Homo sapiens 110-116 25400722-11 2014 Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3. Curcumin 41-49 mitogen-activated protein kinase 3 Homo sapiens 190-196 24287376-3 2014 We discovered that curcumin treatment could promote the number of processes, mean process length, and maximum process length of primary neurons, which were inhibited by reggie-1 siRNAs or extracellular signal-regulated kinase (ERK) 1/2 antagonist. Curcumin 19-27 mitogen-activated protein kinase 3 Homo sapiens 188-235 24806432-4 2014 To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2. Curcumin 59-67 mitogen-activated protein kinase 3 Homo sapiens 101-107 24806432-4 2014 To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2. Curcumin 59-67 mitogen-activated protein kinase 3 Homo sapiens 320-326 24806432-7 2014 Furthermore, blockade of ERK1/2 and exogenous expression of FOXO3a restored the effect of curcumin on growth of cells. Curcumin 90-98 mitogen-activated protein kinase 3 Homo sapiens 25-31 24806432-8 2014 Together, our studies show that curcumin inhibits growth and induces apoptosis of NPC cells through ERK1/2-mediated increase in the protein expression and interaction of p53 and FOXO3a. Curcumin 32-40 mitogen-activated protein kinase 3 Homo sapiens 100-106 24287376-4 2014 Furthermore, curcumin-induced neurite growth was related to the ERK1/2 phosphorylation, which was blocked by reggie-1 knockdown. Curcumin 13-21 mitogen-activated protein kinase 3 Homo sapiens 64-70 24287376-5 2014 Overall, our results implied that curcumin could mediate neurite outgrowth through reggie-1 and ERK1/2 pathway. Curcumin 34-42 mitogen-activated protein kinase 3 Homo sapiens 96-102 23888319-4 2014 In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin 28-36 mitogen-activated protein kinase 3 Homo sapiens 117-158 23317243-8 2012 Curcumin also markedly inhibited TGF-beta1-regulated MMP-9 and activation of Smad2, ERK1/2 and p38 in a dose- and time-dependent manner. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 84-90 24025356-3 2013 The role of ERK1/2 signaling is clearly complex, for example as shown by the Koumenis group where inhibition of radiation-induced ERK1/2 signaling caused radiosensitization, whereas inhibition of curcumin-hyper-stimulated ERK1/2 signaling reduced radiosensitivity. Curcumin 196-204 mitogen-activated protein kinase 3 Homo sapiens 12-18 23726918-4 2013 Curcumin enhanced Erk1/2 predominantly in Ras-activated cells, but inhibited Akt and its downstream molecules (mTOR and S6K1) regardless of these oncogene activations. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 18-24 23726918-7 2013 By contrast, drastic increases of G2/M cell populations were seen in Ras-activated cells rather than Src-activated cells, suggesting a potential role of Ras/Erk1/2 activation in curcumin-induced G2/M arrest. Curcumin 178-186 mitogen-activated protein kinase 3 Homo sapiens 157-163 23532091-10 2013 Curcumin increased extracellular signal-regulated kinase 1/2 activity in both SKN and SK-UT-1 cells, whereas PD98059, an MEK1 inhibitor, inhibited both the extracellular signal-regulated kinase 1/2 pathway and curcumin-induced autophagy. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 19-60 23532091-10 2013 Curcumin increased extracellular signal-regulated kinase 1/2 activity in both SKN and SK-UT-1 cells, whereas PD98059, an MEK1 inhibitor, inhibited both the extracellular signal-regulated kinase 1/2 pathway and curcumin-induced autophagy. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 19-58 24216994-4 2013 An inhibitor to MEK or curcumin significantly suppressed the phosphorylation of ERK1/2 and expression of VEGF. Curcumin 23-31 mitogen-activated protein kinase 3 Homo sapiens 80-86 23645731-5 2013 Upon curcumin treatment, AKT activation was substantially suppressed, with subsequent reduction of activities of mammalian target of rapamycin (mTOR) and its downstream molecules S6 kinase-1 (S6K1) and elF4E-binding protein-1 (4E-BP1), but constitutive activity of extracellular signal-regulated kinase (ERK1/2) was clearly enhanced. Curcumin 5-13 mitogen-activated protein kinase 3 Homo sapiens 304-310 23658623-7 2013 Curcumin-mediated up-regulation of CD69 at late phase was associated with ERK1/2 signaling. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 74-80 23347846-10 2013 Furthermore, curcumin inhibited activation of NF-kappaB and induced dephosphorylation of ERK1/2. Curcumin 13-21 mitogen-activated protein kinase 3 Homo sapiens 89-95 22298641-4 2012 Curcumin rapidly induced activation of the mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK). Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 138-144 22298641-5 2012 Inhibition of JNK (with SP600125) or Erk1/2 (with U0126) partially prevented curcumin-induced cell death in the cells. Curcumin 77-85 mitogen-activated protein kinase 3 Homo sapiens 37-43 22298641-6 2012 Similarly, expression of dominant negative c-Jun or downregulation of Erk1/2 in part attenuated curcumin-induced cell death. Curcumin 96-104 mitogen-activated protein kinase 3 Homo sapiens 70-76 22298641-8 2012 Furthermore, we found that curcumin-induced activation of MAPK pathways was related to inhibition of the serine/threonine protein phosphatases 2A (PP2A) and 5 (PP5). Curcumin 27-35 mitogen-activated protein kinase 3 Homo sapiens 58-62 22298641-9 2012 Overexpression of PP2A or PP5 partially prevented curcumin-induced activation of JNK and Erk1/2 phosphorylation as well as cell death. Curcumin 50-58 mitogen-activated protein kinase 3 Homo sapiens 89-95 24369247-5 2013 Treatment of Jurkat cells with 25, 50, and 75 micromol/L curcumin resulted in a concentration-dependent increase of JNK and p-JNK expressions (P<0.01) without significantly affecting the expressions of ERK1/2 and P38 MAPK or the activity of MMP-2 and MMP-9. Curcumin 57-65 mitogen-activated protein kinase 3 Homo sapiens 205-211 23985704-8 2013 Mechanistic studies indicate that the effects of both curcumin and PFBr4 on PC-3 cells were associated with a decrease in phospho-Akt and phospho-extracellular signal-regulated kinase (Erk)1/2. Curcumin 54-62 mitogen-activated protein kinase 3 Homo sapiens 146-192 21932059-5 2012 Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylation of ERK1/2 and p38. Curcumin 18-26 mitogen-activated protein kinase 3 Homo sapiens 127-133 21932059-7 2012 We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders. Curcumin 16-24 mitogen-activated protein kinase 3 Homo sapiens 97-101 21973306-0 2012 Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression. Curcumin 51-59 mitogen-activated protein kinase 3 Homo sapiens 99-105 21973306-5 2012 Therefore, in this study, we suggested that curcumin enhances the effects of MMC-mediated cytotoxicity by decreasing TP expression and ERK1/2 activation. Curcumin 44-52 mitogen-activated protein kinase 3 Homo sapiens 135-141 21973306-6 2012 Exposure of human NSCLC cell lines H1975 and H1650 to curcumin decreased MMC-elicited phosphorylated MKK1/2-ERK1/2 protein levels. Curcumin 54-62 mitogen-activated protein kinase 3 Homo sapiens 108-114 21973306-8 2012 Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased TP protein levels and cell viability in curcumin- and MMC-co-treated cells. Curcumin 127-135 mitogen-activated protein kinase 3 Homo sapiens 15-21 18332871-8 2008 In addition, curcumin reduced the phosphorylation levels of PDGF-betaR and EGFR, as well as their downstream signaling cascades, including ERK1/2 and JNK1/2. Curcumin 13-21 mitogen-activated protein kinase 3 Homo sapiens 139-145 21810436-0 2011 Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 84-90 21461234-6 2011 We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK). Curcumin 36-44 mitogen-activated protein kinase 3 Homo sapiens 67-114 21461234-6 2011 We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK). Curcumin 36-44 mitogen-activated protein kinase 3 Homo sapiens 158-162 19676105-9 2010 Curcumin also activated p38 mitogen-activated protein kinase (MAPK) without altering extracellular signal-regulated kinase 1/2 activity. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 62-66 19676105-10 2010 We conclude that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of prosurvival Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin. Curcumin 33-41 mitogen-activated protein kinase 3 Homo sapiens 100-104 21810436-5 2011 Exposure of two human non-small lung cancer (NSCLC) cell lines (A549 and H1975) to curcumin could suppress MMC-induced MKK1/2-ERK1/2 signal activation and Rad51 protein expression. Curcumin 83-91 mitogen-activated protein kinase 3 Homo sapiens 126-132 21810436-6 2011 Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased Rad51 protein levels in curcumin and MMC co-treated human lung cells. Curcumin 111-119 mitogen-activated protein kinase 3 Homo sapiens 15-21 21810436-7 2011 Moreover, the synergistic cytotoxic effect induced by curcumin combined with MMC was decreased by MKK1-CA-mediated enhancement of ERK1/2 activation by a significant degree. Curcumin 54-62 mitogen-activated protein kinase 3 Homo sapiens 130-136 21810436-8 2011 In contrast, MKK1/2 inhibitor, U0126 was shown to augment the cytotoxicity of curcumin and MMC through downregulation of ERK1/2 activation and Rad51 expression. Curcumin 78-86 mitogen-activated protein kinase 3 Homo sapiens 121-127 21484156-0 2011 Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 54-58 21484156-3 2011 In this study, we investigated whether curcumin and resveratrol can synergistically inhibit the catabolic effects of IL-1beta, specifically the inhibition of the MAPK and subsequent apoptosis in human articular chondrocytes. Curcumin 39-47 mitogen-activated protein kinase 3 Homo sapiens 162-166 21484156-8 2011 Furthermore, curcumin and resveratrol inhibited IL-1beta- or U0126-induced apoptosis and downregulation of beta1-integrins and Erk1/2 in human articular chondrocytes. Curcumin 13-21 mitogen-activated protein kinase 3 Homo sapiens 127-133 20160040-5 2010 TxnRd1 knockdown cells showed decreased radiation-induced reactive oxygen species and sustained extracellular signal-regulated kinase 1/2 activation, which we previously showed was required for curcumin-mediated radiosensitization. Curcumin 194-202 mitogen-activated protein kinase 3 Homo sapiens 96-137 18357586-2 2008 Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase. Curcumin 21-29 mitogen-activated protein kinase 3 Homo sapiens 134-140 18357586-3 2008 In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression. Curcumin 43-51 mitogen-activated protein kinase 3 Homo sapiens 61-67 17493651-6 2007 In contrast, apigenin, a dietary flavonoid derived from plants and vegetables, and curcumin, an agent derived from turmeric, inhibit differentiation by suppressing MAPK signal transduction and reducing API transcription factor level. Curcumin 83-91 mitogen-activated protein kinase 3 Homo sapiens 164-168 18252805-7 2008 The antioxidant compound N-acetylcysteine blocked the curcumin-induced increased reactive oxygen species (ROS), sustained activation of ERK1/2, and decreased survival after IR in HeLa cells, implicating a ROS-dependent mechanism for curcumin radiosensitivity. Curcumin 54-62 mitogen-activated protein kinase 3 Homo sapiens 136-142 18252805-9 2008 Together, these results suggest a novel mechanism for curcumin-mediated radiosensitization involving increased ROS and ERK1/2 activation and suggest that curcumin application (either systemically or topically) may be an effective radiation modifying modality in the treatment of cervical cancer. Curcumin 54-62 mitogen-activated protein kinase 3 Homo sapiens 119-125 17786026-0 2007 Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Curcumin 62-70 mitogen-activated protein kinase 3 Homo sapiens 33-39 17374178-10 2007 Inhibition of ERKs activation by AG126, AP-1 by curcumin, and JNKs by SP600125 could reduced the induction of cyclin D1 and CDK4, whereas inhibition of p38K by SB203580 did not show any inhibitory effects on S-HELF. Curcumin 48-56 mitogen-activated protein kinase 3 Homo sapiens 14-18 17395690-9 2007 It is interesting that activation of the Akt pathway inhibited curcumin-induced autophagy and cytotoxicity, whereas inhibition of the ERK1/2 pathway inhibited curcumin-induced autophagy and induced apoptosis, thus resulting in enhanced cytotoxicity. Curcumin 159-167 mitogen-activated protein kinase 3 Homo sapiens 134-140 17882652-9 2007 In p34 cells, combination of curcumin and gemcitabine downregulated both COX-2 and p-ERK1/2 in a dose-dependent manner. Curcumin 29-37 mitogen-activated protein kinase 3 Homo sapiens 85-91 17201164-0 2006 Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. Curcumin 66-74 mitogen-activated protein kinase 3 Homo sapiens 167-173 17201164-4 2006 Our aim was to evaluate whether the curcumin inhibitory effect on the survival of cancer cells is associated with simultaneous down-regulation of COX-2 and EGFR and inhibition of Erk1/2 (extra-cellular signal regulated kinase) signaling pathway. Curcumin 36-44 mitogen-activated protein kinase 3 Homo sapiens 179-185 17201164-10 2006 In the p34 and PC-14 cells, curcumin decreased COX-2, EGFR and p-Erk1/2 expressions in a dose-dependent manner. Curcumin 28-36 mitogen-activated protein kinase 3 Homo sapiens 65-71 17201164-12 2006 CONCLUSION: Curcumin co-inhibited COX-2 and EGFR expression and decreased Erk1/2 activity. Curcumin 12-20 mitogen-activated protein kinase 3 Homo sapiens 74-80 16356124-0 2005 Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 117-123 16356124-5 2005 Curcumin blocked TPA-induced activation of extracellular signal-regulated protein kinase (ERK1/2) and nuclear factor kappaB (NF-kappaB) transcriptional activity. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 90-96 16356124-8 2005 Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential. Curcumin 44-52 mitogen-activated protein kinase 3 Homo sapiens 126-132 35182412-0 2022 Curcumin Mitigates TNFalpha-Induced Caco-2 Cell Monolayer Permeabilization Through modulation of NF-kappaB, ERK1/2 and JNK Pathways. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 108-114 15569263-7 2004 We found that curcumin inhibited Abeta1-40-induced MAP kinase activation and the phosphorylation of ERK-1/2 and its downstream target Elk-1. Curcumin 14-22 mitogen-activated protein kinase 3 Homo sapiens 100-107 12527329-0 2003 Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells. Curcumin 153-161 mitogen-activated protein kinase 3 Homo sapiens 47-51 12527329-3 2003 After pre-treatment of cells for 20 min, curcumin (40 microM) inhibited EGF-stimulated phosphorylation of the EGFR in MDA-MB-468 cells and phosphorylation of extracellular signal regulated kinases (ERKs) 1 and 2, as well as ERK activity and levels of nuclear c-fos in both cell lines. Curcumin 41-49 mitogen-activated protein kinase 3 Homo sapiens 198-201 12527329-9 2003 These results suggest that while curcumin has several different molecular targets within the MAPK and PI3K/PKB signalling pathways that could contribute to inhibition of proliferation and induction of apoptosis, inhibition of basal activity of Akt/PKB, but not ERK, may facilitate apoptosis in the tumour cell line. Curcumin 33-41 mitogen-activated protein kinase 3 Homo sapiens 93-97 12527329-9 2003 These results suggest that while curcumin has several different molecular targets within the MAPK and PI3K/PKB signalling pathways that could contribute to inhibition of proliferation and induction of apoptosis, inhibition of basal activity of Akt/PKB, but not ERK, may facilitate apoptosis in the tumour cell line. Curcumin 33-41 mitogen-activated protein kinase 3 Homo sapiens 261-264 11425486-6 2001 Curcumin and SB203580, which inhibit JNK and p38 MAPK signaling pathways, but not herbimycin A/staurosporine, prevented the MGO-induced PARP degradation. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 49-53 34727633-0 2022 Curcumin represses lipid accumulation through inhibiting ERK1/2-PPAR-gamma signaling pathway and triggering apoptosis in porcine subcutaneous preadipocytes. Curcumin 0-8 mitogen-activated protein kinase 3 Homo sapiens 57-63 11207308-8 2001 Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation. Curcumin 11-19 mitogen-activated protein kinase 3 Homo sapiens 224-230 11207308-8 2001 Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation. Curcumin 21-38 mitogen-activated protein kinase 3 Homo sapiens 224-230 35182412-6 2022 CONCLUSION: The inhibition of NF-kappaB, ERK1/2 and JNK activation could be in part involved in the capacity of curcumin to mitigate intestinal inflammation, oxidant production, activation of redox-sensitive pathways, and prevention of monolayer permeabilization. Curcumin 112-120 mitogen-activated protein kinase 3 Homo sapiens 41-47