PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34481181-8 2021 MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene. Curcumin 298-306 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 46-51 33479401-0 2021 Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies. Curcumin 13-21 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 36-37 33479401-4 2021 It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex). Curcumin 70-78 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 130-131 33479401-4 2021 It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex). Curcumin 70-78 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 227-232 33479401-5 2021 The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively. Curcumin 44-52 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 61-62 33479401-6 2021 Curcumin directly binds to the receptor binding domain (RBD) of viral S Protein. Curcumin 0-8 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 70-71 33479401-10 2021 Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex. Curcumin 51-59 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 187-188 33397223-0 2021 Virtual screening of curcumin and its analogs against the spike surface glycoprotein of SARS-CoV-2 and SARS-CoV. Curcumin 21-29 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 58-63 33397223-7 2021 In the present study, curcumin and its derivatives were docked, using Autodock 4.2, onto the 6CRV and 6M0J to study their capability to act as inhibitors of the spike protein and thereby, viral entry. Curcumin 22-30 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 161-166 33397223-10 2021 A good binding energy, drug likeness and efficient pharmacokinetic parameters suggest the potential of curcumin and few of its derivatives as SARS-CoV-2 spike protein inhibitors. Curcumin 103-111 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 153-158 33850236-0 2021 Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies. Curcumin 32-40 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 55-56 33149560-8 2020 However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78. Curcumin 99-107 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 137-142 34481181-10 2021 RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry. Curcumin 40-48 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 101-106 34481181-10 2021 RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry. Curcumin 40-48 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 120-125 34481181-13 2021 CONCLUSION: This result provides a significant insight about the phytochemicals" role, namely curcumin and piperine, as the potential therapeutic entities against mutated spike protein of SARS-CoV-2. Curcumin 94-102 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 171-176 34574194-5 2021 Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host"s immune response. Curcumin 31-39 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 190-195 35259661-5 2022 The present study focused on curcumin derivatives with reliable ADME profile and high molecular binding potency to different SARS-CoV-2 target enzymes (3CLPro, PLpro, NSP7/8/12, NSP7/8/12 +RNA, NSP15, NSP16, Spike, Spike+ACE). Curcumin 29-37 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 208-213 34138966-5 2021 Here, we provide experimental evidence that, among 56 tested polyphenols, including plant extracts, brazilin, theaflavin-3,3"-digallate, and curcumin displayed the highest binding with the receptor-binding domain of spike protein, inhibiting viral attachment to the human angiotensin-converting enzyme 2 receptor, and thus cellular entry of pseudo-typed SARS-CoV-2 virions. Curcumin 141-149 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 216-221 35259661-5 2022 The present study focused on curcumin derivatives with reliable ADME profile and high molecular binding potency to different SARS-CoV-2 target enzymes (3CLPro, PLpro, NSP7/8/12, NSP7/8/12 +RNA, NSP15, NSP16, Spike, Spike+ACE). Curcumin 29-37 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 215-220 35508082-0 2022 Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study. Curcumin 0-8 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 18-23 35508082-4 2022 METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex. Curcumin 302-310 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 48-53 35508082-4 2022 METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex. Curcumin 302-310 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 159-164