PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31485636-10	2019	It was also observed that curcumin treatment downregulated the expression levels of TXNIP, NLRP3, interleukin (IL)-1beta and IL-18, and downstream caspase-1 compared with PQ treatment alone.	Curcumin	26-34	NLR family pyrin domain containing 3	Homo sapiens	91-96	
32507349-6	2020	METHOD: Three phytochemicals; Sulforaphane, Curcumin, and Resveratrol were selected, and studies were reviewed to clarify their intracellular signaling mechanism in NLRP3 inflammasome activity.	Curcumin	44-52	NLR family pyrin domain containing 3	Homo sapiens	165-170	
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	NLR family pyrin domain containing 3	Homo sapiens	194-199	
31485636-12	2019	The present findings suggested that the inhibitory effects of curcumin on TXINP1 may inhibit activation of the NLRP3 inflammasome, subsequently suppressing the upregulation of proinflammatory cytokines and ultimately improving PQ-induced ALI.	Curcumin	62-70	NLR family pyrin domain containing 3	Homo sapiens	111-116	
27777559-2	2016	This study aimed to assess the effects of curcumin on NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism.	Curcumin	42-50	NLR family pyrin domain containing 3	Homo sapiens	54-59	
27777559-0	2016	Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA-Induced Macrophages.	Curcumin	0-8	NLR family pyrin domain containing 3	Homo sapiens	19-24	
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Curcumin	9-17	NLR family pyrin domain containing 3	Homo sapiens	58-63	
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Curcumin	13-21	NLR family pyrin domain containing 3	Homo sapiens	104-109	
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Curcumin	12-20	NLR family pyrin domain containing 3	Homo sapiens	31-36	
25791922-0	2015	Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.	Curcumin	0-8	NLR family pyrin domain containing 3	Homo sapiens	108-113	
25791922-6	2015	As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion.	Curcumin	13-21	NLR family pyrin domain containing 3	Homo sapiens	61-66	
25791922-6	2015	As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion.	Curcumin	13-21	NLR family pyrin domain containing 3	Homo sapiens	112-117	
25791922-9	2015	Immunohistochemistry showed that curcumin inhibited p-IRE1alpha, p-PERK and NLRP3 expression in hippocampus CA1 region.	Curcumin	33-41	NLR family pyrin domain containing 3	Homo sapiens	76-81	
25791922-10	2015	Together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation via the regulation of AMPK, and thereby protected the hippocampus from ischemic insult.	Curcumin	36-44	NLR family pyrin domain containing 3	Homo sapiens	121-126