PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22752008-3 2012 Studies with recombinant human cytochromes P450 (P450s) indicate CYP2D6, CYP3A4, and CYP3A5 are the primary isoforms responsible for the oxidative metabolism of DM1, (S)-methyl-DM1, and DM4. Maytansine 186-189 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 85-91