PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11059798-4 2000 The pharmacological properties of neuronal and astrocytic GABA uptake have been studied extensively and recently the GABA analogue N-methyl-Exo-THPO has been reported to act as a selective and potent (IC50 28 microM) astroglial GABA transport inhibitor with a 15-fold selectivity. gamma-Aminobutyric Acid 58-62 thrombopoietin Mus musculus 144-148 12130726-7 2002 exo-THPO and its N-alkyl analogs inhibited neuronal, astrocytic, and GAT1-mediated GABA transport but not GABA uptake mediated by GAT2-4. gamma-Aminobutyric Acid 83-87 thrombopoietin Mus musculus 4-8 12130726-7 2002 exo-THPO and its N-alkyl analogs inhibited neuronal, astrocytic, and GAT1-mediated GABA transport but not GABA uptake mediated by GAT2-4. gamma-Aminobutyric Acid 106-110 thrombopoietin Mus musculus 4-8 12130726-8 2002 N-Methyl-exo-THPO was 8-fold more potent as an inhibitor of astrocytic versus neuronal GABA uptake. gamma-Aminobutyric Acid 87-91 thrombopoietin Mus musculus 13-17 12130726-15 2002 Furthermore, results obtained with the N-methyl-exo-THPO prodrug demonstrate the feasibility of developing a glial-selective GABA uptake inhibitor with systemic bioavailability. gamma-Aminobutyric Acid 125-129 thrombopoietin Mus musculus 52-56 11059798-4 2000 The pharmacological properties of neuronal and astrocytic GABA uptake have been studied extensively and recently the GABA analogue N-methyl-Exo-THPO has been reported to act as a selective and potent (IC50 28 microM) astroglial GABA transport inhibitor with a 15-fold selectivity. gamma-Aminobutyric Acid 117-121 thrombopoietin Mus musculus 144-148 11059798-4 2000 The pharmacological properties of neuronal and astrocytic GABA uptake have been studied extensively and recently the GABA analogue N-methyl-Exo-THPO has been reported to act as a selective and potent (IC50 28 microM) astroglial GABA transport inhibitor with a 15-fold selectivity. gamma-Aminobutyric Acid 117-121 thrombopoietin Mus musculus 144-148 8319739-1 1993 The N-4,4-diphenyl-3-butenyl derivative of the glial selective gamma-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. gamma-Aminobutyric Acid 63-86 thrombopoietin Mus musculus 166-170 8319739-1 1993 The N-4,4-diphenyl-3-butenyl derivative of the glial selective gamma-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. gamma-Aminobutyric Acid 88-92 thrombopoietin Mus musculus 166-170