PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9829997-1 1998 The inhibition of gamma-aminobutyric acid (GABA)-gated chloride currents by the protein kinase C (PKC) activator 4beta-phorbol 12-myristate 13-acetate (PMA) was investigated using recombinant human GABAA receptors expressed in Xenopus oocytes. gamma-Aminobutyric Acid 43-47 GABA(A) receptor-associated protein L homeolog Xenopus laevis 198-203 10397373-2 1999 Propofol and pentobarbitone enhanced agonist (GABA or glycine as appropriate) evoked currents at GABA(A), glycine, and RDL receptors, whereas etomidate and 5alpha3alpha were highly selective for the GABA(A) receptor. gamma-Aminobutyric Acid 46-50 GABA(A) receptor-associated protein L homeolog Xenopus laevis 97-104 9105230-2 1997 Many general anesthetics are reported to potentiate gamma-aminobutyric acid (GABAA) and glycine receptors in the central nervous system (CNS) and to inhibit the muscle-type nicotinic acetylcholine receptor (nAChR). gamma-Aminobutyric Acid 52-75 GABA(A) receptor-associated protein L homeolog Xenopus laevis 77-82 9176994-2 1997 The translation of gamma aminobutyric acid type A (GABAA) receptors has been shown by dose/ response behavior of GABA and the reversible blockade of the GABA-induced current by picrotoxin. gamma-Aminobutyric Acid 51-55 GABA(A) receptor-associated protein L homeolog Xenopus laevis 19-49 9176994-2 1997 The translation of gamma aminobutyric acid type A (GABAA) receptors has been shown by dose/ response behavior of GABA and the reversible blockade of the GABA-induced current by picrotoxin. gamma-Aminobutyric Acid 113-117 GABA(A) receptor-associated protein L homeolog Xenopus laevis 19-49 9176994-2 1997 The translation of gamma aminobutyric acid type A (GABAA) receptors has been shown by dose/ response behavior of GABA and the reversible blockade of the GABA-induced current by picrotoxin. gamma-Aminobutyric Acid 113-117 GABA(A) receptor-associated protein L homeolog Xenopus laevis 51-56 8613812-4 1996 Whole-cell recordings from RB neurons and from neighboring dorsolateral interneurons (DLi) revealed that GABA responses of both cells were mediated by GABAA receptors. gamma-Aminobutyric Acid 105-109 GABA(A) receptor-associated protein L homeolog Xenopus laevis 151-156 8977405-0 1997 Neuroendocrine gamma-aminobutyric acid (GABA): functional differences in GABAA versus GABAB receptor inhibition of the melanotrope cell of Xenopus laevis. gamma-Aminobutyric Acid 15-38 GABA(A) receptor-associated protein L homeolog Xenopus laevis 73-78 8977405-0 1997 Neuroendocrine gamma-aminobutyric acid (GABA): functional differences in GABAA versus GABAB receptor inhibition of the melanotrope cell of Xenopus laevis. gamma-Aminobutyric Acid 40-44 GABA(A) receptor-associated protein L homeolog Xenopus laevis 73-78 8884747-1 1996 In the central nervous system (CNS), the inhibitory transmitter GABA interacts with three subtypes of GABA receptors, type A, type B, and type C. Historically, GABA receptors have been classified as either the inotropic GABAA receptors or the metabotropic GABAB receptors. gamma-Aminobutyric Acid 64-68 GABA(A) receptor-associated protein L homeolog Xenopus laevis 220-225 8381070-2 1993 The effects of GABA are mediated by GABAA and/or GABAB receptors. gamma-Aminobutyric Acid 15-19 GABA(A) receptor-associated protein L homeolog Xenopus laevis 36-41 7681105-3 1993 Potentiation of GABA-activated currents by enflurane was dependent on the composition of GABAA receptor protein subunits; the order of sensitivity was alpha 1 beta 1 > alpha 1 beta 1 gamma 2S = alpha 1 beta 1 gamma 2L > total mRNA. gamma-Aminobutyric Acid 16-20 GABA(A) receptor-associated protein L homeolog Xenopus laevis 89-94 8381070-4 1993 In the amphibian Xenopus laevis, GABA inhibits the release of alpha MSH from the endocrine melanotrope cells through both GABAA and GABAB receptors. gamma-Aminobutyric Acid 33-37 GABA(A) receptor-associated protein L homeolog Xenopus laevis 122-127 33808090-3 2021 Recently, an increased use-dependent desensitization due to a repetitive GABA stimulation (GABAA current rundown) of GABAARs has been associated with drug-resistant temporal lobe epilepsy (TLE). gamma-Aminobutyric Acid 73-77 GABA(A) receptor-associated protein L homeolog Xenopus laevis 91-96 1664974-2 1991 Its action on GABA-induced response was quantitatively studied on the GABAA receptor expressed in Xenopus oocytes after injection of chick brain mRNA under voltage-clamp conditions. gamma-Aminobutyric Acid 14-18 GABA(A) receptor-associated protein L homeolog Xenopus laevis 70-75 27392961-1 2016 Potentiation of gamma-amino butyric acid (GABA)-induced GABAA receptor (GABAAR) activation is a common pathway to achieve sedative, sleep-enhancing, anxiolytic, and antidepressant effects. gamma-Aminobutyric Acid 16-40 GABA(A) receptor-associated protein L homeolog Xenopus laevis 56-61 20504530-11 1989 The results implicate GABA, acting through GABA-A and possibly GABA-B receptors, in the regulation of NAT activity in retina. gamma-Aminobutyric Acid 22-26 GABA(A) receptor-associated protein L homeolog Xenopus laevis 43-49 3026779-5 1987 Both the GABA agonists (GABAa) homotaurine and isoguvacine and the GABA agonist (GABAb) baclofen inhibited MSH release in a dose-dependent manner. gamma-Aminobutyric Acid 9-13 GABA(A) receptor-associated protein L homeolog Xenopus laevis 24-29 28416372-1 2017 Anxiolytics and anticonvulsants generally positively modulate the action of GABA, whereas many convulsants (including the chloride channel blocker picrotoxinin) negatively modulate the action of GABA on GABAA receptors. gamma-Aminobutyric Acid 195-199 GABA(A) receptor-associated protein L homeolog Xenopus laevis 203-208 28416372-2 2017 Like picrotoxinin, bilobalide and ginkgolide B, active constituents of Ginkgo biloba, have been shown to negatively modulate the action of GABA at alpha1beta2gamma2L GABAA receptors. gamma-Aminobutyric Acid 139-143 GABA(A) receptor-associated protein L homeolog Xenopus laevis 166-171 27392961-1 2016 Potentiation of gamma-amino butyric acid (GABA)-induced GABAA receptor (GABAAR) activation is a common pathway to achieve sedative, sleep-enhancing, anxiolytic, and antidepressant effects. gamma-Aminobutyric Acid 42-46 GABA(A) receptor-associated protein L homeolog Xenopus laevis 56-61 21715633-1 2011 Ionotropic GABA receptors (GABA(A) and GABA(C)) belong to the Cys-loop receptor family of ligand-gated ion channels. gamma-Aminobutyric Acid 11-15 GABA(A) receptor-associated protein L homeolog Xenopus laevis 27-34 25224408-1 2015 Insulin, when co-applied with GABA, can cause an inhibition of the induced current at GABAA receptors. gamma-Aminobutyric Acid 30-34 GABA(A) receptor-associated protein L homeolog Xenopus laevis 86-91 25224408-7 2015 The differences in insulin inhibition of GABA currents at different alpha containing GABAA receptors could be important in autocrine and paracrine control of hormone secretion in the pancreas, and in control of reward and food intake circuits of the brain. gamma-Aminobutyric Acid 41-45 GABA(A) receptor-associated protein L homeolog Xenopus laevis 85-90 24680924-1 2014 Valerenic acid (VA) is a beta2/3 subunit-specific modulator of gamma-aminobutyric acid (GABA) type A (GABAA) receptors inducing anxiolysis. gamma-Aminobutyric Acid 63-86 GABA(A) receptor-associated protein L homeolog Xenopus laevis 102-107 24680924-1 2014 Valerenic acid (VA) is a beta2/3 subunit-specific modulator of gamma-aminobutyric acid (GABA) type A (GABAA) receptors inducing anxiolysis. gamma-Aminobutyric Acid 88-92 GABA(A) receptor-associated protein L homeolog Xenopus laevis 102-107 15456793-1 2004 ATP and gamma-aminobutyric acid (GABA) are two fast neurotransmitters co-released at central synapses, where they co-activate excitatory P2X and inhibitory GABAA (GABA type A) receptors. gamma-Aminobutyric Acid 8-31 GABA(A) receptor-associated protein L homeolog Xenopus laevis 156-161 18599601-4 2008 The mutants were expressed in Xenopus laevis oocytes and tested for sensitivities of GABA-induced currents to the GABAA and GABAC receptor antagonists. gamma-Aminobutyric Acid 85-89 GABA(A) receptor-associated protein L homeolog Xenopus laevis 114-119 15814572-3 2005 To assess this quantitatively, we used Xenopus laevis oocytes expressing alpha1beta2gamma2S-containing GABA(A) receptors to demonstrate that coexpression of GABARAP increased net surface levels of GABA(A) receptors as shown by both increased GABA currents and surface-expressed protein. gamma-Aminobutyric Acid 103-107 GABA(A) receptor-associated protein L homeolog Xenopus laevis 157-164 15814572-4 2005 This GABARAP stimulation of GABA currents required the receptor gamma2 subunit and full-length GABARAP: deletion of the microtubule-binding domain (amino acids 1-22) or disrupting the polymerization of microtubules abolished the enhancement, indicating that the effect of GABARAP was derived from the interaction with microtubules. gamma-Aminobutyric Acid 5-9 GABA(A) receptor-associated protein L homeolog Xenopus laevis 95-102 15814572-4 2005 This GABARAP stimulation of GABA currents required the receptor gamma2 subunit and full-length GABARAP: deletion of the microtubule-binding domain (amino acids 1-22) or disrupting the polymerization of microtubules abolished the enhancement, indicating that the effect of GABARAP was derived from the interaction with microtubules. gamma-Aminobutyric Acid 5-9 GABA(A) receptor-associated protein L homeolog Xenopus laevis 95-102 15456793-1 2004 ATP and gamma-aminobutyric acid (GABA) are two fast neurotransmitters co-released at central synapses, where they co-activate excitatory P2X and inhibitory GABAA (GABA type A) receptors. gamma-Aminobutyric Acid 33-37 GABA(A) receptor-associated protein L homeolog Xenopus laevis 156-161 15456793-3 2004 Sequential applications of GABA and ATP revealed that alphabeta- or alphabetagamma-containing GABAA receptors inhibited P2X2 channels, whereas P2X2 channels failed to inhibit gamma-containing GABAA receptors. gamma-Aminobutyric Acid 27-31 GABA(A) receptor-associated protein L homeolog Xenopus laevis 94-99 10998097-1 2000 Functional coassembly of gamma-aminobutyric acid (GABA)C rho1 subunits with GABAA (alpha1, beta2, and gamma2S) or glycine (alpha1, alpha2, and beta) subunits was examined using two-electrode voltage-clamp recordings in the Xenopus laevis oocyte expression system. gamma-Aminobutyric Acid 50-54 GABA(A) receptor-associated protein L homeolog Xenopus laevis 76-81 10998097-1 2000 Functional coassembly of gamma-aminobutyric acid (GABA)C rho1 subunits with GABAA (alpha1, beta2, and gamma2S) or glycine (alpha1, alpha2, and beta) subunits was examined using two-electrode voltage-clamp recordings in the Xenopus laevis oocyte expression system. gamma-Aminobutyric Acid 25-48 GABA(A) receptor-associated protein L homeolog Xenopus laevis 76-81 10781289-6 2000 The response to GABA of alpha1beta2gamma2s GABAA receptors expressed in human embryonic kidney cells and Xenopus oocytes was compared with and without coapplication of ketamine from 1 microm to 10 mm. gamma-Aminobutyric Acid 16-20 GABA(A) receptor-associated protein L homeolog Xenopus laevis 43-48