PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9161749-1 1997 PURPOSE: Acetylcholinesterase and butyrylcholinesterase are two closely related enzymes important in the metabolism of acetylcholine and anaesthetic drugs, including succinylcholine, mivacurium, and cocaine. Cocaine 199-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 10910502-3 2000 Cholinesterases such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyze and inactivate several anesthetic drugs, including cocaine, heroin, esmolol, local ester anesthetics, and neuromuscular blocking drugs. Cocaine 147-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 16854005-3 2005 Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine. Cocaine 212-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 16288482-2 2006 The computational results consistently reveal a unique role of the oxyanion hole (consisting of G116, G117, and A199) in BChE-catalyzed hydrolysis of cocaine, compared to acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine. Cocaine 150-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 27392137-0 2016 Cocaine cardiovascular effects and pharmacokinetics after treatment with the acetylcholinesterase inhibitor donepezil. Cocaine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 24643289-4 2014 The catalytic efficiency of E30-6 for cocaine hydrolysis is comparable to that of the most efficient known naturally occurring hydrolytic enzyme, acetylcholinesterase, the catalytic activity of which approaches the diffusion limit. Cocaine 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 19836169-3 2010 Because AChE inhibitors have been shown to decrease the reinforcing effects of cocaine in animals, our hypothesis was that pretreatment with donepezil would attenuate the perceived value and other positive subjective effects of cocaine. Cocaine 79-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 20641589-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Cocaine 96-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 20641640-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Cocaine 96-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18468882-0 2008 Development of a bifunctional sensor using haptenized acetylcholinesterase and application for the detection of cocaine and organophosphates. Cocaine 112-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 18468882-4 2008 For this reason the cocaine derivative benzoylecgonine (BZE) was coupled via a 10A long hydrophilic linker - 1,8-diamino-3,4-dioxaoctane - to carboxylic groups of the AChE after EDC/NHS activation. Cocaine 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 18468882-8 2008 Furthermore it was also shown that other cocaine-binding enzymes, e.g., butyrylcholinesterase, can bind to the modified BZE-AChE. Cocaine 41-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-128 16256090-3 2005 Exposure to organophosphate (OP) chemical warfare agents (CWAs), pesticides, anesthetics, and a variety of drugs such as cocaine, as well as some neurodegenerative and liver disease states, selectively reduces AChE or BChE activity. Cocaine 121-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 16854005-8 2005 These results help to understand why the catalytic activity of AChE against ACh is considerably higher than that of BChE against cocaine and provides valuable clues on how to improve the catalytic activity of BChE against cocaine. Cocaine 129-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 14738173-5 2003 Acetylcholinesterase (a possible detoxifier of cocaine) abolished the effect of cocaine on prostacyclin production. Cocaine 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 14738173-5 2003 Acetylcholinesterase (a possible detoxifier of cocaine) abolished the effect of cocaine on prostacyclin production. Cocaine 80-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 198-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 198-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 198-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 12721372-8 2003 These results demonstrate that centrally active AChE inhibitors prevent long-lasting behavioral abnormalities associated with cocaine and morphine addictions by potentiating the actions of ACh released from the NAc cholinergic neurons. Cocaine 126-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52