PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22243740-0	2012	Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.	Cocaine	87-94	histone deacetylase 5	Homo sapiens	47-52	
22243740-1	2012	The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine.	Cocaine	83-90	histone deacetylase 5	Homo sapiens	24-29	
22243750-0	2012	Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.	Cocaine	29-36	histone deacetylase 5	Homo sapiens	0-21	
22243750-2	2012	We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum.	Cocaine	20-27	histone deacetylase 5	Homo sapiens	125-130	
22243750-5	2012	Importantly, we show that dephosphorylation of HDAC5 S279 in the nucleus accumbens suppresses the development, but not expression, of cocaine reward behavior in vivo.	Cocaine	134-141	histone deacetylase 5	Homo sapiens	47-52	
22243750-6	2012	Together, our findings reveal a molecular mechanism by which cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, likely by putting a brake on drug-stimulated gene expression that supports drug-induced behavioral changes.	Cocaine	61-68	histone deacetylase 5	Homo sapiens	79-84	
22243750-6	2012	Together, our findings reveal a molecular mechanism by which cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, likely by putting a brake on drug-stimulated gene expression that supports drug-induced behavioral changes.	Cocaine	132-139	histone deacetylase 5	Homo sapiens	79-84	
28957664-0	2017	HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.	Cocaine	80-87	histone deacetylase 5	Homo sapiens	0-5	
28957664-2	2017	We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model.	Cocaine	109-116	histone deacetylase 5	Homo sapiens	40-61	
28957664-2	2017	We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model.	Cocaine	109-116	histone deacetylase 5	Homo sapiens	63-68	
28957674-3	2017	(2017) suggests that targets of nuclear HDAC5 mediate the behavioral effects of rewarding drugs via regulation of cocaine-associated stimuli.	Cocaine	114-121	histone deacetylase 5	Homo sapiens	40-45	
17988625-4	2007	utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine.	Cocaine	131-138	histone deacetylase 5	Homo sapiens	33-38	
17988634-4	2007	Chronic, but not acute, exposure to cocaine or stress decreases HDAC5 function in the nucleus accumbens (NAc), a major brain reward region, which allows for increased histone acetylation and transcription of HDAC5 target genes.	Cocaine	36-43	histone deacetylase 5	Homo sapiens	64-69	
17988634-4	2007	Chronic, but not acute, exposure to cocaine or stress decreases HDAC5 function in the nucleus accumbens (NAc), a major brain reward region, which allows for increased histone acetylation and transcription of HDAC5 target genes.	Cocaine	36-43	histone deacetylase 5	Homo sapiens	208-213	
28635037-4	2018	Cocaine triggers a transient nuclear accumulation of HDAC5 that functions to limit the development of cocaine reward behavior.	Cocaine	0-7	histone deacetylase 5	Homo sapiens	53-58	
28635037-4	2018	Cocaine triggers a transient nuclear accumulation of HDAC5 that functions to limit the development of cocaine reward behavior.	Cocaine	102-109	histone deacetylase 5	Homo sapiens	53-58	
28635037-6	2018	In this study, we report that cocaine and cAMP signaling in striatum produced differential phosphorylation and subcellular localization of HDAC4 and HDAC5.	Cocaine	30-37	histone deacetylase 5	Homo sapiens	149-154	
28635037-10	2018	Together, our findings suggest that, despite high sequence homology, HDAC4 and HDAC5 are oppositely regulated by cocaine-induced signaling in vivo and have distinct roles in regulating cocaine behaviors.	Cocaine	113-120	histone deacetylase 5	Homo sapiens	79-84