PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19203409-0	2009	Aquaporin 4 knockout resists negative regulation of neural cell proliferation by cocaine in mouse hippocampus.	Cocaine	81-88	aquaporin 4	Mus musculus	0-11	
19203409-5	2009	Further studies through immunohistochemistry and immunoblot analysis showed that AQP4 knockout sustained the levels of glial fibrillary acidic protein in the hippocampus, and suppressed the enhancement of extracellular signal-regulated kinase phosphorylation induced by repeated cocaine administration.	Cocaine	279-286	aquaporin 4	Mus musculus	81-85	
19203409-7	2009	We also found that repeated cocaine administration could elevate the expression of AQP4 in wild-type mice.	Cocaine	28-35	aquaporin 4	Mus musculus	83-87	
19203409-8	2009	In conclusion, it is reported for the first time that AQP4 knockout resisted cocaine-mediated inhibition of neural cell proliferation via up-regulating PKC-mediated signal transduction, suggesting that AQP4 might regulate neurogenesis during drug addiction.	Cocaine	77-84	aquaporin 4	Mus musculus	54-58	
19203409-8	2009	In conclusion, it is reported for the first time that AQP4 knockout resisted cocaine-mediated inhibition of neural cell proliferation via up-regulating PKC-mediated signal transduction, suggesting that AQP4 might regulate neurogenesis during drug addiction.	Cocaine	77-84	aquaporin 4	Mus musculus	202-206	
19203409-1	2009	Our previous study revealed that aquaporin 4 (AQP4) knockout attenuated locomotor activity in cocaine exposure mice and reduced the extracellular dopamine levels in the nucleus accumbens, suggesting that AQP4 might participate in cocaine addiction.	Cocaine	94-101	aquaporin 4	Mus musculus	33-44	
19203409-1	2009	Our previous study revealed that aquaporin 4 (AQP4) knockout attenuated locomotor activity in cocaine exposure mice and reduced the extracellular dopamine levels in the nucleus accumbens, suggesting that AQP4 might participate in cocaine addiction.	Cocaine	94-101	aquaporin 4	Mus musculus	46-50	
19203409-1	2009	Our previous study revealed that aquaporin 4 (AQP4) knockout attenuated locomotor activity in cocaine exposure mice and reduced the extracellular dopamine levels in the nucleus accumbens, suggesting that AQP4 might participate in cocaine addiction.	Cocaine	94-101	aquaporin 4	Mus musculus	204-208	
19203409-2	2009	The aim of the present study was to investigate the impact of AQP4 on cell proliferation of dentate gyrus in the mouse hippocampus after repeated cocaine treatment and withdrawal.	Cocaine	146-153	aquaporin 4	Mus musculus	62-66	
19203409-4	2009	AQP4 knockout resisted cocaine-induced reductions of neural cell proliferation.	Cocaine	23-30	aquaporin 4	Mus musculus	0-4	
16797122-0	2006	Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice.	Cocaine	31-38	aquaporin 4	Mus musculus	0-11	
16797122-5	2006	The results reveal that AQP4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (NAc), a brain region known to be critically involved in the addictive properties of cocaine.	Cocaine	90-97	aquaporin 4	Mus musculus	24-28	
16797122-5	2006	The results reveal that AQP4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (NAc), a brain region known to be critically involved in the addictive properties of cocaine.	Cocaine	293-300	aquaporin 4	Mus musculus	24-28	
16797122-6	2006	Therefore, AQP4 may play a role in regulating extracellular cocaine-induced dopamine and glutamate release in the brain reward center, and in turn AQP4 deletion may attenuate cocaine reinforcement and dependence.	Cocaine	60-67	aquaporin 4	Mus musculus	11-15	
32335199-5	2020	We found that cocaine treatment, both during repeated exposure and withdrawal, significantly induced widespread astrogliosis and reduced cerebral blood flow (CBF), cerebrovascular pulsatility, and aquaporin-4 (AQP4) polarity.	Cocaine	14-21	aquaporin 4	Mus musculus	197-208	
32335199-5	2020	We found that cocaine treatment, both during repeated exposure and withdrawal, significantly induced widespread astrogliosis and reduced cerebral blood flow (CBF), cerebrovascular pulsatility, and aquaporin-4 (AQP4) polarity.	Cocaine	14-21	aquaporin 4	Mus musculus	210-214