PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33417223-0	2021	NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation.	Cocaine	36-43	NLR family pyrin domain containing 3	Homo sapiens	0-5	
33417223-3	2021	Based on the premise that cocaine induces both reactive oxygen species (ROS) as well as microglial activation, we hypothesized that cocaine-mediated microglial activation involves both ROS and NLRP3 signaling pathways.	Cocaine	26-33	NLR family pyrin domain containing 3	Homo sapiens	193-198	
33417223-3	2021	Based on the premise that cocaine induces both reactive oxygen species (ROS) as well as microglial activation, we hypothesized that cocaine-mediated microglial activation involves both ROS and NLRP3 signaling pathways.	Cocaine	132-139	NLR family pyrin domain containing 3	Homo sapiens	193-198	
33417223-5	2021	We found that microglia exposed to cocaine exhibited significant induction of NLRP3 and mature IL-1beta expression.	Cocaine	35-42	NLR family pyrin domain containing 3	Homo sapiens	78-83	
33417223-6	2021	Intriguingly, blockade of ROS (Tempol) attenuated cocaine-mediated priming of NLRP3 and microglial activation (CD11b).	Cocaine	50-57	NLR family pyrin domain containing 3	Homo sapiens	78-83	
33417223-7	2021	Blockade of NLRP3 by both pharmacological (MCC950) as well as gene silencing (siNLRP3) approaches underpinned the critical role of NLRP3 in cocaine-mediated activation of inflammasome and microglial activation.	Cocaine	140-147	NLR family pyrin domain containing 3	Homo sapiens	12-17	
33417223-7	2021	Blockade of NLRP3 by both pharmacological (MCC950) as well as gene silencing (siNLRP3) approaches underpinned the critical role of NLRP3 in cocaine-mediated activation of inflammasome and microglial activation.	Cocaine	140-147	NLR family pyrin domain containing 3	Homo sapiens	80-85	
33417223-9	2021	Furthermore, cortical brain tissues of chronic cocaine-dependent humans also exhibited upregulated expression of the NLRP3 pathway mediators compared with non-cocaine dependent controls.	Cocaine	47-54	NLR family pyrin domain containing 3	Homo sapiens	117-122	
33417223-9	2021	Furthermore, cortical brain tissues of chronic cocaine-dependent humans also exhibited upregulated expression of the NLRP3 pathway mediators compared with non-cocaine dependent controls.	Cocaine	159-166	NLR family pyrin domain containing 3	Homo sapiens	117-122	
33417223-10	2021	Collectively, these findings suggest that cocaine activates microglia involving the NLRP3 inflammasome pathway, thereby contributing to neuroinflammation.	Cocaine	42-49	NLR family pyrin domain containing 3	Homo sapiens	84-89	
33417223-11	2021	NLRP3 can thus be considered as a potential therapeutic target for alleviating cocaine-mediated neuroinflammation.	Cocaine	79-86	NLR family pyrin domain containing 3	Homo sapiens	0-5	
27321752-2	2016	In human inflammasome PCR array, among different involved in inflammasome formation, in HIV infected macrophages in the presence of cocaine, we have observed significant upregulation of NLRP3, AIM2 genes and downstream genes IL-1beta and PTGS2.	Cocaine	132-139	NLR family pyrin domain containing 3	Homo sapiens	186-191	
27321752-8	2016	These results indicate that in case of HIV infected macrophages exposed to cocaine, increased ROS production and IL-1beta transcription serve as an activators for the formation of NLRP3 and AIM2 mediated inflammasomes that leads to caspase 1 mediated apoptosis.	Cocaine	75-82	NLR family pyrin domain containing 3	Homo sapiens	180-185