PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8308010-9	1994	Specifically, the recombinant ferrochelatase has iron and porphyrin as substrates, and N-methylprotoporphyrin and metal ions (e.g. Hg2+ and Mn2+), as strong inhibitors of its enzyme activity.	N-methylprotoporphyrin IX	87-109	ferrochelatase	Homo sapiens	30-44	
3218729-3	1988	That zinc chelatase and ferrochelatase activities reside in the same enzyme was shown by the competitive action of ferrous ions and the inhibitory effects of N-methyl protoporphyrin (a specific inhibitor of heme synthetase) on zinc chelatase.	N-methylprotoporphyrin IX	158-181	ferrochelatase	Homo sapiens	207-222	
29985945-7	2018	Treatment of BCAs with NMPP initiated a time- and dose-dependent attenuation of FECH activity without changes in its protein expression, followed by significant reduction in the heme level.	N-methylprotoporphyrin IX	23-27	ferrochelatase	Homo sapiens	80-84	
25414439-8	2015	That ferrochelatase is essential to parasite growth was confirmed by showing that inhibition of ferrochelatase using the specific competitive inhibitor, N-methylprotoporphyrin, produced a potent growth inhibition effect against cultures of P falciparum.	N-methylprotoporphyrin IX	153-175	ferrochelatase	Homo sapiens	5-19	
25414439-8	2015	That ferrochelatase is essential to parasite growth was confirmed by showing that inhibition of ferrochelatase using the specific competitive inhibitor, N-methylprotoporphyrin, produced a potent growth inhibition effect against cultures of P falciparum.	N-methylprotoporphyrin IX	153-175	ferrochelatase	Homo sapiens	96-110	
19002554-3	2009	We repressed heme synthesis in cells by inhibiting ferrochelatase enzyme with small interfering RNA and N-methylprotoporphyrin IX.	N-methylprotoporphyrin IX	104-129	ferrochelatase	Homo sapiens	51-65	
16792525-0	2006	Modulation of inhibition of ferrochelatase by N-methylprotoporphyrin.	N-methylprotoporphyrin IX	46-68	ferrochelatase	Homo sapiens	28-42	
16792525-2	2006	NMPP (N-methylprotoporphyrin), a transition-state analogue and potent inhibitor of ferrochelatase, is commonly used to induce haem deficiency in mammalian cell cultures.	N-methylprotoporphyrin IX	0-4	ferrochelatase	Homo sapiens	83-97	
16792525-2	2006	NMPP (N-methylprotoporphyrin), a transition-state analogue and potent inhibitor of ferrochelatase, is commonly used to induce haem deficiency in mammalian cell cultures.	N-methylprotoporphyrin IX	6-28	ferrochelatase	Homo sapiens	83-97	
16792525-7	2006	Further, although NMPP binding to either wild-type ferrochelatase or P255R occurred via a similar two-step kinetic mechanism, the forward and reverse rate constants associated with the second and rate-limiting step were comparable for the two enzymes.	N-methylprotoporphyrin IX	18-22	ferrochelatase	Homo sapiens	51-65	
12417755-2	2002	Heme deficiency was induced with N-methylprotoporphyrin IX, a selective inhibitor of ferrochelatase, in two human brain cell lines, SHSY5Y (neuroblastoma) and U373 (astrocytoma), as well as in rat primary hippocampal neurons.	N-methylprotoporphyrin IX	33-58	ferrochelatase	Homo sapiens	85-99