PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23641325-6 2013 For both the compounds, a concentration of 10 muM (equivalent to 1.88 mug/ml for plumbagin and 3.68 mug/ml for sanguinarine) resulted in 100% mortality at 48 h, which meets the World Health Organization"s (WHO) criterion of "hit" compounds for the control of schistosomiasis. sanguinarine 111-123 latexin Homo sapiens 46-49 27420038-3 2016 Sanguinarine, chelerythrine and chelidonine depolymerized the microtubule network in living cancer cells (Hela cells and human osteosarcoma U2OS cells) and inhibited tubulin polymerization in vitro with IC50 values of 48.41 +- 3.73, 206.39 +- 4.20 and 34.51 +- 9.47 muM, respectively. sanguinarine 0-12 latexin Homo sapiens 266-269 23500771-4 2013 The results showed that SAG was a potent noncompetitive inhibitor of CYP2C8 activity (Ki=8.9 muM), and competitive inhibitor of CYP1A2, CYP2C9 and CYP3A4 activities (Ki=2.7, 3.8 and 2.0 muM, respectively). sanguinarine 24-27 latexin Homo sapiens 93-96 23500771-4 2013 The results showed that SAG was a potent noncompetitive inhibitor of CYP2C8 activity (Ki=8.9 muM), and competitive inhibitor of CYP1A2, CYP2C9 and CYP3A4 activities (Ki=2.7, 3.8 and 2.0 muM, respectively). sanguinarine 24-27 latexin Homo sapiens 186-189