PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21538419-10 2012 Sanguinarine downregulates the expression of Stat3-mediated genes such as c-myc and survivin and inhibits the Stat3 responsive element luciferase reporter activity. sanguinarine 0-12 MYC proto-oncogene, bHLH transcription factor Homo sapiens 74-79 28968696-10 2017 Chromatin immunoprecipitation assay demonstrated that Nanog directly binds to promoters of Cdk2, Cdk6, FGF4, c-Myc and Oct4, and sanguinarine inhibits the binding of Nanog with these genes, suggesting the direct involvement of Nanog in cell cycle, pluripotency and self-renewal. sanguinarine 129-141 MYC proto-oncogene, bHLH transcription factor Homo sapiens 109-114 23562763-0 2013 Molecular basis of recognition of quadruplexes human telomere and c-myc promoter by the putative anticancer agent sanguinarine. sanguinarine 114-126 MYC proto-oncogene, bHLH transcription factor Homo sapiens 66-71 23562763-1 2013 BACKGROUND: Interaction of putative anticancer agent sanguinarine with two quadruplex forming sequences, human telomeric DNA (H24) and NHE III1 upstream of the P1 promoter of c-myc (Pu27), has been studied to understand the structural basis of the recognition. sanguinarine 53-65 MYC proto-oncogene, bHLH transcription factor Homo sapiens 175-180