PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23660334-3	2013	Sanguinarine also promoted the activation of caspase-8 and truncation of Bid (tBid).	sanguinarine	0-12	BH3 interacting domain death agonist	Homo sapiens	73-76	
27363951-3	2016	Sanguinarine treatment increased DR5/TRAILR2 (death receptor 5/TRAIL receptor 2) expression and enhanced the activation of caspase-8 and cleavage of its substrate, Bid.	sanguinarine	0-12	BH3 interacting domain death agonist	Homo sapiens	164-167	
18667818-8	2008	Sanguinarine also promoted the activation of caspase-8 and truncation of Bid (tBid).	sanguinarine	0-12	BH3 interacting domain death agonist	Homo sapiens	73-76	
20032392-5	2009	Combined treatment with sanguinarine and TRAIL effectively induced Bid cleavage and loss of mitochondrial membrane potential, leading to the activation of caspases, and cleavage of poly(ADP-ribose) polymerase and beta-catenin.	sanguinarine	24-36	BH3 interacting domain death agonist	Homo sapiens	67-70	
23717422-4	2013	Sanguinarine-induced apoptosis was correlated with the up-regulation of Bax, the down-regulation of Bid and XIAP, the activation of caspases (-3, -8, and -9), and the generation of increased reactive oxygen species (ROS).	sanguinarine	0-12	BH3 interacting domain death agonist	Homo sapiens	100-103	
17005319-6	2007	Further, sanguinarine-treatment to AsPC-1 and BxPC-3 cells resulted in a dose dependent (i) increase in pro-apoptotic Bax, Bid and Bak proteins; (ii) decrease in anti-apoptotic Bcl-2 and Bcl-X(L) proteins; and (iii) decrease in p53 with an increase in its phosphorylation.	sanguinarine	9-21	BH3 interacting domain death agonist	Homo sapiens	123-126	
17440103-3	2007	Our data show that sanguinarine treatment of PEL cells results in up-regulation of death receptor 5 (DR5) expression via generation of reactive oxygen species (ROS) and causes activation of caspase-8 and truncation of Bid (tBid).	sanguinarine	19-31	BH3 interacting domain death agonist	Homo sapiens	218-221	
12912970-9	2003	Sanguinarine also resulted in significant increases in the proapoptotic members of Bcl-2 family proteins, i.e., Bak and Bid.	sanguinarine	0-12	BH3 interacting domain death agonist	Homo sapiens	120-123	
16505117-5	2006	These responses on UVB and/or sanguinarine treatments were associated with (a) decrease in Bcl-2 and Bcl-X(L) and (b) increase in Bax, Bid, and Bak protein levels.	sanguinarine	30-42	BH3 interacting domain death agonist	Homo sapiens	135-138