PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18667818-7	2008	RESULTS: The results of this study demonstrate that sanguinarine mediates ROS production, and that this mediation is followed by a decrease in MMP, the release of cytochrome c, activation of caspase-9 and caspase-3, and downregulation of antiapoptosis factor XIAP and cIAP-1.	sanguinarine	52-64	cytochrome c, somatic	Homo sapiens	163-175	
23499690-6	2013	Sanguinarine disrupted the mitochondrial transmembrane potential (DeltaPsim), released cytochrome c and Smac/DIABLO from mitochondria to cytosol, and induced oxidative stress.	sanguinarine	0-12	cytochrome c, somatic	Homo sapiens	87-99	
18325696-8	2008	Thus, our results demonstrated that rapid cytochrome c release in CEM T-leukemia cells exposed to sanguinarine or chelerythrine was not accompanied by changes in Bax, Bcl-2 and Bcl-X((L/S)) proteins in the mitochondrial fraction, and preceded activation of the initiator caspase-8.	sanguinarine	98-110	cytochrome c, somatic	Homo sapiens	42-54	
18667818-11	2008	CONCLUSION: Our data imply that sanguinarine-induced ROS are key mediators of MMP collapse, which leads to the release of cytochrome c followed by caspase activation, culminating in apoptosis.	sanguinarine	32-44	cytochrome c, somatic	Homo sapiens	122-134	
27363951-4	2016	Sanguinarine also induced the mitochondrial translocation of pro-apoptotic Bax, mitochondrial dysfunction, cytochrome c release to the cytosol, and activation of caspase-9 and -3.	sanguinarine	0-12	cytochrome c, somatic	Homo sapiens	107-119	
18325696-2	2008	In this study, we found that sanguinarine and chelerythrine induce apoptosis in human CEM T-leukemia cells, and that is accompanied by an early increase in cytosolic cytochrome c that precedes caspases-8, -9 and -3 processing.	sanguinarine	29-41	cytochrome c, somatic	Homo sapiens	166-178	
17440103-5	2007	Sanguinarine-induced release of cytochrome c results in activation of caspase-9 and caspase-3 and poly(ADP-ribose) polymerase (PARP) cleavage, leading to induction of caspase-dependent apoptosis.	sanguinarine	0-12	cytochrome c, somatic	Homo sapiens	32-44