PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29731961-9 2018 The NFkappaB inhibitor Sanguinarine resulted in a decrease in MMP7 protein expression and both NFkappaB inhibitor Sanguinarine and MMP inhibitor Batimastat prevented occludin degradation and budding. sanguinarine 23-35 nuclear factor kappa B subunit 1 Homo sapiens 4-12 29731961-9 2018 The NFkappaB inhibitor Sanguinarine resulted in a decrease in MMP7 protein expression and both NFkappaB inhibitor Sanguinarine and MMP inhibitor Batimastat prevented occludin degradation and budding. sanguinarine 23-35 nuclear factor kappa B subunit 1 Homo sapiens 95-103 29731961-9 2018 The NFkappaB inhibitor Sanguinarine resulted in a decrease in MMP7 protein expression and both NFkappaB inhibitor Sanguinarine and MMP inhibitor Batimastat prevented occludin degradation and budding. sanguinarine 114-126 nuclear factor kappa B subunit 1 Homo sapiens 95-103 30074177-0 2018 Sanguinarine Attenuates Lipopolysaccharide-induced Inflammation and Apoptosis by Inhibiting the TLR4/NF-kappaB Pathway in H9c2 Cardiomyocytes. sanguinarine 0-12 nuclear factor kappa B subunit 1 Homo sapiens 101-110 22965493-4 2012 Sanguinarine caused a dose-dependent decrease in Bcl-2 and NF-kappaB protein expression and a significant increase in Bax protein expression. sanguinarine 0-12 nuclear factor kappa B subunit 1 Homo sapiens 59-68 9374492-0 1997 Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation. sanguinarine 0-12 nuclear factor kappa B subunit 1 Homo sapiens 60-69 9374492-0 1997 Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation. sanguinarine 14-33 nuclear factor kappa B subunit 1 Homo sapiens 60-69 9374492-3 1997 In the present report we show that sanguinarine (a benzophenanthridine alkaloid), a known anti-inflammatory agent, is a potent inhibitor of NF-kappaB activation. sanguinarine 35-47 nuclear factor kappa B subunit 1 Homo sapiens 140-149 9374492-4 1997 Treatment of human myeloid ML-1a cells with tumor necrosis factor rapidly activated NF-kappaB, this activation was completely suppressed by sanguinarine in a dose- and time-dependent manner. sanguinarine 140-152 nuclear factor kappa B subunit 1 Homo sapiens 84-93 9374492-5 1997 Sanguinarine did not inhibit the binding of NF-kappaB protein to the DNA but rather inhibited the pathway leading to NF-kappaB activation. sanguinarine 0-12 nuclear factor kappa B subunit 1 Homo sapiens 117-126 9374492-6 1997 The reversal of inhibitory effects of sanguinarine by reducing agents suggests a critical sulfhydryl group is involved in NF-kappaB activation. sanguinarine 38-50 nuclear factor kappa B subunit 1 Homo sapiens 122-131 9374492-7 1997 Sanguinarine blocked the tumor necrosis factor-induced phosphorylation and degradation of IkappaBalpha, an inhibitory subunit of NF-kappaB, and inhibited translocation of p65 subunit to the nucleus. sanguinarine 0-12 nuclear factor kappa B subunit 1 Homo sapiens 129-138 9374492-8 1997 As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1, phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers. sanguinarine 3-15 nuclear factor kappa B subunit 1 Homo sapiens 31-40 9374492-8 1997 As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1, phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers. sanguinarine 3-15 nuclear factor kappa B subunit 1 Homo sapiens 190-199 15313406-4 2004 Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect. sanguinarine 113-125 nuclear factor kappa B subunit 1 Homo sapiens 251-260 11502101-0 2001 Bax, Bcl-2, and NF-kappaB expression in sanguinarine induced bimodal cell death. sanguinarine 40-52 nuclear factor kappa B subunit 1 Homo sapiens 16-25 11502101-1 2001 The apoptosis related proteins Bax, Bcl-2, and NF-kappaB were analyzed in sanguinarine induced apoptosis and blister cell death (BCD) of K562 erythroleukemia cells and in sanguinarine treated high Bcl-2 expressing JM1 pre-B lymphoblastic cells, utilizing immunofluorescence-flow cytometry. sanguinarine 74-86 nuclear factor kappa B subunit 1 Homo sapiens 47-56 11502101-2 2001 Sanguinarine induced apoptosis of K562 cells was found to have increased Bax expression and decreased NF-kappaB, whereas BCD showed a decrease in Bax expression and an increase in NF-kappaB. sanguinarine 0-12 nuclear factor kappa B subunit 1 Homo sapiens 102-111 11502101-2 2001 Sanguinarine induced apoptosis of K562 cells was found to have increased Bax expression and decreased NF-kappaB, whereas BCD showed a decrease in Bax expression and an increase in NF-kappaB. sanguinarine 0-12 nuclear factor kappa B subunit 1 Homo sapiens 180-189 9374492-9 1997 Overall, our results demonstrate that sanguinarine is a potent suppressor of NF-kappaB activation and it acts at a step prior to IkappaBalpha phosphorylation. sanguinarine 38-50 nuclear factor kappa B subunit 1 Homo sapiens 77-86