PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25704029-1 2015 Previous studies show that several pathways are involved in sanguinarine-induced apoptotic cell death, including AKT downregulation, inhibition of NF-kB activation, mediation of ROS production, downregulation of anti-apoptosis proteins XIAP and cIAP-1, upregulation of BAX, and downregulation of BCL2. sanguinarine 60-72 nuclear factor kappa B subunit 1 Rattus norvegicus 147-152