PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28123499-9	2017	In addition, western blot analysis demonstrated that the ratio of B-cell lymphoma 2/Bcl-2-associated X protein was significantly increased following treatment with sanguinarine (P<0.05).	sanguinarine	164-176	BCL2, apoptosis regulator	Rattus norvegicus	84-89	
25704029-0	2015	BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells.	sanguinarine	75-87	BCL2, apoptosis regulator	Rattus norvegicus	0-4	
25704029-1	2015	Previous studies show that several pathways are involved in sanguinarine-induced apoptotic cell death, including AKT downregulation, inhibition of NF-kB activation, mediation of ROS production, downregulation of anti-apoptosis proteins XIAP and cIAP-1, upregulation of BAX, and downregulation of BCL2.	sanguinarine	60-72	BCL2, apoptosis regulator	Rattus norvegicus	296-300	
25704029-4	2015	We showed that sanguinarine-induced down regulation of BCL2 was associated with the increased methylation rate of BCL2 promotor district and the increased expression of miR-15a/16-1.	sanguinarine	15-27	BCL2, apoptosis regulator	Rattus norvegicus	55-59	
25704029-4	2015	We showed that sanguinarine-induced down regulation of BCL2 was associated with the increased methylation rate of BCL2 promotor district and the increased expression of miR-15a/16-1.	sanguinarine	15-27	BCL2, apoptosis regulator	Rattus norvegicus	114-118	
25704029-5	2015	HSC-T6 cells treatment with 5-Aza-2"-deoxycytidine (5"-Aza-CdR) impeded sanguinarine-induced BCL2 promotor district methylation and recovered BCL2"s expression.	sanguinarine	72-84	BCL2, apoptosis regulator	Rattus norvegicus	93-97	
25704029-6	2015	Over expression of BCL2 using pEGFP-N1 vector decreased sanguinarine-induced HSC-T6 cells apoptotic death significantly but not completely.	sanguinarine	56-68	BCL2, apoptosis regulator	Rattus norvegicus	19-23	
25704029-7	2015	These observations clearly showed that BCL2 down regulation was associated with its promoter methylation and miR-15a/16-1 upregulation in sanguinarine-induced Rat HSC-T6 cells.	sanguinarine	138-150	BCL2, apoptosis regulator	Rattus norvegicus	39-43	
24300172-6	2014	SANG-induced apoptosis was correlated with the up-regulation of Bax/Bcl2 ratio and the down-regulation of Bcl2.	sanguinarine	0-4	BCL2, apoptosis regulator	Rattus norvegicus	68-72	
24300172-6	2014	SANG-induced apoptosis was correlated with the up-regulation of Bax/Bcl2 ratio and the down-regulation of Bcl2.	sanguinarine	0-4	BCL2, apoptosis regulator	Rattus norvegicus	106-110	
17667597-0	2007	Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt.	sanguinarine	26-38	BCL2, apoptosis regulator	Rattus norvegicus	109-114	
17667597-4	2007	The sanguinarine treatment induced the proteolytic activation of caspases and ICAD/DFF45, which was associated with the modulation of the Bcl-2 family, concomitant degradation of poly(ADP ribose) polymerase and phospholipase C-gamma1 protein, and DNA fragmentation.	sanguinarine	4-16	BCL2, apoptosis regulator	Rattus norvegicus	138-143