PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33636580-7 2021 Sanguinarine inhibited the activation of downstream protein signal transducer and activator of transcription-3 (STAT3), thereby blocking hypoxia-induced HIF-1alpha/STAT3 interaction and downregulating the mRNA levels of their target genes. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 60-110 33636580-7 2021 Sanguinarine inhibited the activation of downstream protein signal transducer and activator of transcription-3 (STAT3), thereby blocking hypoxia-induced HIF-1alpha/STAT3 interaction and downregulating the mRNA levels of their target genes. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 112-117 33636580-7 2021 Sanguinarine inhibited the activation of downstream protein signal transducer and activator of transcription-3 (STAT3), thereby blocking hypoxia-induced HIF-1alpha/STAT3 interaction and downregulating the mRNA levels of their target genes. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 164-169 33636580-9 2021 Sanguinarine inhibited STAT3 activation through targeting its upstream EphB4 and accelerating STAT3 dephosphorylation. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 23-28 33636580-9 2021 Sanguinarine inhibited STAT3 activation through targeting its upstream EphB4 and accelerating STAT3 dephosphorylation. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 94-99 32065498-0 2020 Sanguinarine disrupts the colocalization and interaction of HIF-1alpha with tyrosine and serine phosphorylated-STAT3 in breast cancer. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 111-116 32065498-7 2020 Sanguinarine could inhibit the nuclear colocalization and interaction of HIF-1alpha with p-STAT3-Tyr and p-STAT3-Ser in vivo and in vitro. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 91-96 32065498-7 2020 Sanguinarine could inhibit the nuclear colocalization and interaction of HIF-1alpha with p-STAT3-Tyr and p-STAT3-Ser in vivo and in vitro. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 107-112 32065498-8 2020 Our results may bring insights to the HIF-1alpha/STAT3 interaction in breast cancers and suggest sanguinarine as a promising candidate for HIF-alpha/STAT3 inhibition. sanguinarine 97-109 signal transducer and activator of transcription 3 Homo sapiens 149-154 31616177-0 2019 Sanguinarine exhibits potent efficacy against cervical cancer cells through inhibiting the STAT3 pathway in vitro and in vivo. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 91-96 31616177-10 2019 Western blot analysis results revealed that SNG-induced antitumor effect might be mediated by STAT3 inhibition. sanguinarine 44-47 signal transducer and activator of transcription 3 Homo sapiens 94-99 31058086-0 2019 Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 97-102 24875448-5 2014 Western blotting analysis revealed that suppression of BLBC growth by sanguinarine was correlated with a concurrent upregulation of p27 and downregulation of cyclin D1 and with the inhibition of STAT3 activation. sanguinarine 70-82 signal transducer and activator of transcription 3 Homo sapiens 195-200 21538419-0 2012 Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. sanguinarine 34-46 signal transducer and activator of transcription 3 Homo sapiens 14-19 21538419-7 2012 RESULTS: In this study, we identified sanguinarine as a potent inhibitor of Stat3 activation which was able to suppress prostate cancer growth, migration, and invasion. sanguinarine 38-50 signal transducer and activator of transcription 3 Homo sapiens 76-81 21538419-8 2012 Sanguinarine inhibits constitutive as well as IL6-induced phosphorylation of Stat3 at both Tyr705 and Ser727 in prostate cancer cells. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 77-82 21538419-9 2012 The inhibition of Stat3 phosphorylation by sanguinarine correlates with reduction of Janus-activated Kinase 2 (Jak2) and Src phosphorylation. sanguinarine 43-55 signal transducer and activator of transcription 3 Homo sapiens 18-23 21538419-10 2012 Sanguinarine downregulates the expression of Stat3-mediated genes such as c-myc and survivin and inhibits the Stat3 responsive element luciferase reporter activity. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 45-50 21538419-10 2012 Sanguinarine downregulates the expression of Stat3-mediated genes such as c-myc and survivin and inhibits the Stat3 responsive element luciferase reporter activity. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 110-115 21538419-11 2012 Sanguinarine inhibits the anchorage-independent growth of DU145 and LN-S17 cells expressing constitutively activated Stat3. sanguinarine 0-12 signal transducer and activator of transcription 3 Homo sapiens 117-122 21538419-13 2012 CONCLUSIONS: These data demonstrate that sanguinarine is a potent Stat3 inhibitor and it could be developed as a therapeutic agent for prostate cancer with constitutive activation of Stat3. sanguinarine 41-53 signal transducer and activator of transcription 3 Homo sapiens 66-71 21538419-13 2012 CONCLUSIONS: These data demonstrate that sanguinarine is a potent Stat3 inhibitor and it could be developed as a therapeutic agent for prostate cancer with constitutive activation of Stat3. sanguinarine 41-53 signal transducer and activator of transcription 3 Homo sapiens 183-188