PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23717422-6	2013	In addition, sanguinarine effectively increased the activation of the c-Jun N-terminal kinase (JNK) and the expression of the early growth response gene-1 (Egr-1), which was recovered by pretreatment with NAC.	sanguinarine	13-25	mitogen-activated protein kinase 8	Homo sapiens	70-93	
23717422-6	2013	In addition, sanguinarine effectively increased the activation of the c-Jun N-terminal kinase (JNK) and the expression of the early growth response gene-1 (Egr-1), which was recovered by pretreatment with NAC.	sanguinarine	13-25	mitogen-activated protein kinase 8	Homo sapiens	95-98	
15753082-7	2005	In a human tumor cell line with high MKP-1 levels, sanguinarine caused enhanced ERK and JNK/SAPK phosphorylation.	sanguinarine	51-63	mitogen-activated protein kinase 8	Homo sapiens	88-91	
15753082-8	2005	A close congener of sanguinarine, chelerythrine, also inhibited MKP-1 in vitro and in whole cells, and activated ERK and JNK/SAPK.	sanguinarine	20-32	mitogen-activated protein kinase 8	Homo sapiens	121-129	
28176854-5	2017	Targeted depletion of PPM1A by shRNA or inhibition of PPM1A activity by sanguinarine restored JNK activation, resulting in increased apoptosis of Mtb-infected macrophages.	sanguinarine	72-84	mitogen-activated protein kinase 8	Homo sapiens	94-97