PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31568920-0 2019 Regulation of p21 expression for anti-apoptotic activity of DDX3 against sanguinarine-induced cell death on intrinsic pathway. sanguinarine 73-85 DEAD-box helicase 3 X-linked Homo sapiens 60-64 31568920-12 2019 Overexpression and knockdown of DDX3 under sanguinarine-treated conditions showed that DDX3 inhibited p21 expression in sanguinarine-treated HeLa cells. sanguinarine 43-55 DEAD-box helicase 3 X-linked Homo sapiens 32-36 31568920-12 2019 Overexpression and knockdown of DDX3 under sanguinarine-treated conditions showed that DDX3 inhibited p21 expression in sanguinarine-treated HeLa cells. sanguinarine 43-55 DEAD-box helicase 3 X-linked Homo sapiens 87-91 31568920-12 2019 Overexpression and knockdown of DDX3 under sanguinarine-treated conditions showed that DDX3 inhibited p21 expression in sanguinarine-treated HeLa cells. sanguinarine 120-132 DEAD-box helicase 3 X-linked Homo sapiens 32-36 31568920-12 2019 Overexpression and knockdown of DDX3 under sanguinarine-treated conditions showed that DDX3 inhibited p21 expression in sanguinarine-treated HeLa cells. sanguinarine 120-132 DEAD-box helicase 3 X-linked Homo sapiens 87-91 31568920-14 2019 CONCLUSION: Taken together, the results suggest that the S90E residue is important for the regulation of p21 expression responsible for the anti-apoptotic activity of DDX3 in HeLa cells treated with sanguinarine. sanguinarine 199-211 DEAD-box helicase 3 X-linked Homo sapiens 167-171 31568920-15 2019 A model of the antiapoptotic function of DDX3 on sanguinarine-treated HeLa cells was proposed to understand the molecular mechanism of the intrinsic apoptosis inhibition in cervical cancer cells. sanguinarine 49-61 DEAD-box helicase 3 X-linked Homo sapiens 41-45 31568920-3 2019 PURPOSE: In this study, we aimed to study the bio-function of DDX3 anti-apoptotic activity in the intrinsic pathway using HeLa cells treated with sanguinarine. sanguinarine 146-158 DEAD-box helicase 3 X-linked Homo sapiens 62-66 31568920-9 2019 DDX3 upregulated anti-apoptotic gene expression (Bcl-xL, cyclin D1, cyclin E, and cyclin B1) and downregulated pro-apoptotic gene expression (caspase-3, Bax) after sanguinarine treatment. sanguinarine 164-176 DEAD-box helicase 3 X-linked Homo sapiens 0-4