PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27363951-4 2016 Sanguinarine also induced the mitochondrial translocation of pro-apoptotic Bax, mitochondrial dysfunction, cytochrome c release to the cytosol, and activation of caspase-9 and -3. sanguinarine 0-12 BCL2 associated X, apoptosis regulator Homo sapiens 75-78 31616177-11 2019 SNG increased the expression of the proapoptotic protein Bax and reduced the expression of the antiapoptotic protein Bcl-2. sanguinarine 0-3 BCL2 associated X, apoptosis regulator Homo sapiens 57-60 29783958-14 2018 The intrinsic apoptosis induced by sanguinarine was Bax-dependent. sanguinarine 35-47 BCL2 associated X, apoptosis regulator Homo sapiens 52-55 27957827-6 2017 Further observation demonstrated that sanguinarine up-regulated the expression of DUSP4 and Bcl-2-associated X protein (Bax), but down-regulated phosphorylated extracellular signal-regulated kinase (p-ERK), proliferating cell nuclear antigen (PCNA), matrix metalloproteinase 2 (MMP-2) and B-cell lymphoma 2 (Bcl-2) expression. sanguinarine 38-50 BCL2 associated X, apoptosis regulator Homo sapiens 92-118 27957827-6 2017 Further observation demonstrated that sanguinarine up-regulated the expression of DUSP4 and Bcl-2-associated X protein (Bax), but down-regulated phosphorylated extracellular signal-regulated kinase (p-ERK), proliferating cell nuclear antigen (PCNA), matrix metalloproteinase 2 (MMP-2) and B-cell lymphoma 2 (Bcl-2) expression. sanguinarine 38-50 BCL2 associated X, apoptosis regulator Homo sapiens 120-123 22215411-0 2012 Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway. sanguinarine 0-12 BCL2 associated X, apoptosis regulator Homo sapiens 87-90 23717422-4 2013 Sanguinarine-induced apoptosis was correlated with the up-regulation of Bax, the down-regulation of Bid and XIAP, the activation of caspases (-3, -8, and -9), and the generation of increased reactive oxygen species (ROS). sanguinarine 0-12 BCL2 associated X, apoptosis regulator Homo sapiens 72-75 22965493-4 2012 Sanguinarine caused a dose-dependent decrease in Bcl-2 and NF-kappaB protein expression and a significant increase in Bax protein expression. sanguinarine 0-12 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 22215411-5 2012 We also investigated the effects of sanguinarine on the expression of apoptosis-associated proteins, and the results revealed that there was an increase in Bax and a decrease in B-cell lymphoma 2 (Bcl-2) protein levels. sanguinarine 36-48 BCL2 associated X, apoptosis regulator Homo sapiens 156-159 17440103-8 2007 Finally, N-acetylcysteine, an inhibitor of ROS, inhibits sanguinarine-induced generation of ROS, up-regulation of DR5, Bax conformational changes, activation of caspase-3, and down-regulation of IAPs. sanguinarine 57-69 BCL2 associated X, apoptosis regulator Homo sapiens 119-122 21868527-5 2011 Finally, sanguinarine induced apoptotic cell death by activating caspase and altering the Bcl-2/Bax ratio. sanguinarine 9-21 BCL2 associated X, apoptosis regulator Homo sapiens 96-99 18325696-3 2008 During apoptosis induction by sanguinarine and chelerythrine, reactive oxygen species (ROS) was rapidly generated and DeltaPsi(mt) dissipated, while Bax, Bcl-2 and Bcl-X((L/S)) proteins" content in the mitochondrial fraction did not change significantly. sanguinarine 30-42 BCL2 associated X, apoptosis regulator Homo sapiens 149-152 18560221-9 2008 Induction of apoptosis by sanguinarine was also accompanied by upregulation of pro-apoptotic Bax and downregulation of anti-apoptotic Bcl-2 expression. sanguinarine 26-38 BCL2 associated X, apoptosis regulator Homo sapiens 93-96 18560221-12 2008 CONCLUSIONS: These results demonstrated that the induction of apoptosis by sanguinarine in U937 cells was associated with altering the balance of Bcl-2 and Bax protein expression and activation of the caspase-3 pathway. sanguinarine 75-87 BCL2 associated X, apoptosis regulator Homo sapiens 156-159 17005319-6 2007 Further, sanguinarine-treatment to AsPC-1 and BxPC-3 cells resulted in a dose dependent (i) increase in pro-apoptotic Bax, Bid and Bak proteins; (ii) decrease in anti-apoptotic Bcl-2 and Bcl-X(L) proteins; and (iii) decrease in p53 with an increase in its phosphorylation. sanguinarine 9-21 BCL2 associated X, apoptosis regulator Homo sapiens 118-121 11787859-3 2001 Here, we report that sanguinarine-treated K562 cells, when analyzed by western blot, showed significant increase in expression of the pro-apoptotic Bax protein in apoptosis, but not in BCD. sanguinarine 21-33 BCL2 associated X, apoptosis regulator Homo sapiens 148-151 16505117-5 2006 These responses on UVB and/or sanguinarine treatments were associated with (a) decrease in Bcl-2 and Bcl-X(L) and (b) increase in Bax, Bid, and Bak protein levels. sanguinarine 30-42 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 16505117-6 2006 Bax knockdown and Bcl-2 overexpression resulted in a rescue of HaCaT cells from sanguinarine-mediated apoptosis. sanguinarine 80-92 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 12912970-8 2003 As shown by the immunoblot analysis, our data clearly demonstrated that sanguinarine treatment to HaCaT cells resulted in a dose-dependent (a) increase in the level of Bax with a concomitant decrease in Bcl-2 levels and (b) increase in Bax/Bcl-2 ratio. sanguinarine 72-84 BCL2 associated X, apoptosis regulator Homo sapiens 168-171 12912970-8 2003 As shown by the immunoblot analysis, our data clearly demonstrated that sanguinarine treatment to HaCaT cells resulted in a dose-dependent (a) increase in the level of Bax with a concomitant decrease in Bcl-2 levels and (b) increase in Bax/Bcl-2 ratio. sanguinarine 72-84 BCL2 associated X, apoptosis regulator Homo sapiens 236-239 16735106-7 2006 Thus, sanguinarine may overcome the phenomenon of Pgp-mediated MDR by inducing apoptosis through increasing the Bax/Bcl-2 ratio and activating caspase-3, and oncosis, which involved neither. sanguinarine 6-18 BCL2 associated X, apoptosis regulator Homo sapiens 112-115 11502101-0 2001 Bax, Bcl-2, and NF-kappaB expression in sanguinarine induced bimodal cell death. sanguinarine 40-52 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 11502101-1 2001 The apoptosis related proteins Bax, Bcl-2, and NF-kappaB were analyzed in sanguinarine induced apoptosis and blister cell death (BCD) of K562 erythroleukemia cells and in sanguinarine treated high Bcl-2 expressing JM1 pre-B lymphoblastic cells, utilizing immunofluorescence-flow cytometry. sanguinarine 74-86 BCL2 associated X, apoptosis regulator Homo sapiens 31-34 11502101-2 2001 Sanguinarine induced apoptosis of K562 cells was found to have increased Bax expression and decreased NF-kappaB, whereas BCD showed a decrease in Bax expression and an increase in NF-kappaB. sanguinarine 0-12 BCL2 associated X, apoptosis regulator Homo sapiens 73-76 11787859-8 2001 These results suggest that sanguinarine in K562 cells induces apoptosis through increasing Bax and activating caspase-3, whereas sanguinarine-induced BCD involves neither. sanguinarine 27-39 BCL2 associated X, apoptosis regulator Homo sapiens 91-94