PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22166397-5	2012	At the concentration of 2 muM, sanguinarine induced nuclear accumulation of Nrf2, increased the expression of Hmox1 gene encoding HO-1 and elevated HO-1 protein levels.	sanguinarine	31-43	heme oxygenase 1	Mus musculus	110-115	
25299846-0	2014	Involvement of heme oxygenase-1 in neuroprotection by sanguinarine against glutamate-triggered apoptosis in HT22 neuronal cells.	sanguinarine	54-66	heme oxygenase 1	Mus musculus	15-31	
25299846-2	2014	In the present study, we demonstrated that sanguinarine markedly induces the expression of HO-1 which leads to a neuroprotective response in mouse hippocampus-derived neuronal HT22 cells from apoptotic cell death induced by glutamate.	sanguinarine	43-55	heme oxygenase 1	Mus musculus	91-95	
25299846-7	2014	Sanguinarine also induced HO-1, NQO-1 expression via activation of Nrf2.	sanguinarine	0-12	heme oxygenase 1	Mus musculus	26-30	
25299846-8	2014	Additionally, we found that si RNA mediated knock-down of Nrf2 or HO-1 significantly inhibited sanguinarine-induced neuroprotective response.	sanguinarine	95-107	heme oxygenase 1	Mus musculus	66-70	
22166397-5	2012	At the concentration of 2 muM, sanguinarine induced nuclear accumulation of Nrf2, increased the expression of Hmox1 gene encoding HO-1 and elevated HO-1 protein levels.	sanguinarine	31-43	heme oxygenase 1	Mus musculus	130-134	
22166397-5	2012	At the concentration of 2 muM, sanguinarine induced nuclear accumulation of Nrf2, increased the expression of Hmox1 gene encoding HO-1 and elevated HO-1 protein levels.	sanguinarine	31-43	heme oxygenase 1	Mus musculus	148-152	
22166397-6	2012	Sanguinarine-induced Hmox1 mRNA expression was suppressed by SB203580, a pharmacologic inhibitor of p38 mitogen-activated protein kinases (p38 MAPKs).	sanguinarine	0-12	heme oxygenase 1	Mus musculus	21-26	
22166397-7	2012	The upregulation of HO-1 in RAW264.7 cells by sanguinarine was, however, accompanied by decrease in cell viability.	sanguinarine	46-58	heme oxygenase 1	Mus musculus	20-24