PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16393932-2 2005 Nerve agent poisoning is conventionally treated using a combination of a cholinolytic (atropine mostly) to counteract the accumulation of acetylcholine and acetylcholinesterase reactivators (pralidoxime or obidoxime) to reactivate inhibited acetylcholinesterase. pralidoxime 191-202 acetylcholinesterase Rattus norvegicus 156-176 214351-4 1978 Electrophysiological studies have shown that paraoxon increases neurotransmitter release and causes spontaneous and impulse-related antidromic nerve activity, both of which can be reduced significantly by reactivation of inhibited acetylcholinesterase (AChE) with pyridine-2-aldoxime methiodide. pralidoxime 264-294 acetylcholinesterase Rattus norvegicus 231-251 214351-4 1978 Electrophysiological studies have shown that paraoxon increases neurotransmitter release and causes spontaneous and impulse-related antidromic nerve activity, both of which can be reduced significantly by reactivation of inhibited acetylcholinesterase (AChE) with pyridine-2-aldoxime methiodide. pralidoxime 264-294 acetylcholinesterase Rattus norvegicus 253-257 32898602-0 2020 Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: pharmacokinetics in rat. pralidoxime 24-44 acetylcholinesterase Rattus norvegicus 140-144 32898602-3 2020 In the present work, we increased brain AChE reactivation efficacy by PEGylation of 2-PAM-SLNs using PEG-lipid N-(carbonyl-methoxypolyethylene glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt) (DSPE-PEG2000) as a surface-modifier of SLNs. pralidoxime 84-89 acetylcholinesterase Rattus norvegicus 40-44 21180265-11 2010 At a higher dose (10(-3) M), pralidoxime reactivated AChE inhibited by paraoxon, chlorpyrifos, Russian VX, VX and sarin. pralidoxime 29-40 acetylcholinesterase Rattus norvegicus 53-57 21180265-12 2010 CONCLUSION: From the obtained results, it is clear that pralidoxime seems to be a poor reactivator of AChE inhibited by organophosphorous AChE inhibitors and thus cannot be labeled as a universal reactivator (Tab. pralidoxime 56-67 acetylcholinesterase Rattus norvegicus 102-106 21180265-12 2010 CONCLUSION: From the obtained results, it is clear that pralidoxime seems to be a poor reactivator of AChE inhibited by organophosphorous AChE inhibitors and thus cannot be labeled as a universal reactivator (Tab. pralidoxime 56-67 acetylcholinesterase Rattus norvegicus 138-142 32319115-2 2020 Oximes, such as the pyridinium oxime pralidoxime (2-PAM) in the United States, can reactivate the inhibited AChE and restore cholinergic function. pralidoxime 37-48 acetylcholinesterase Rattus norvegicus 108-112 32319115-2 2020 Oximes, such as the pyridinium oxime pralidoxime (2-PAM) in the United States, can reactivate the inhibited AChE and restore cholinergic function. pralidoxime 50-55 acetylcholinesterase Rattus norvegicus 108-112 30458229-12 2019 Pralidoxime partially reactivated the AChE activity in the prefrontal cortex, but not in the hippocampus and striatum. pralidoxime 0-11 acetylcholinesterase Rattus norvegicus 38-42 22783142-7 2012 Curcumin when co-supplemented with 2-PAMCl + atropine also significantly protected serum aspartate aminotransferase (AST) and restored brain AChE activity and 5-HT level in animals sub-chronically exposed to DDVP. pralidoxime 35-42 acetylcholinesterase Rattus norvegicus 141-145 19603416-4 2009 The intrinsic AChE inhibitory activity of oximes, as reflected by their in vitro IC(50), is strongly correlated with their LD(50) (rat): oximes with a high IC(50) (K-27, K-48, pralidoxime and obidoxime) also show a high LD(50) and are thus relatively non-toxic, whereas oximes K-105, K-108 and K-113 have a low IC(50), a low LD(50) and are far more toxic. pralidoxime 176-187 acetylcholinesterase Rattus norvegicus 14-18 17265677-1 2006 This paper describes an in vitro study of three potential acetylcholinesterase (AChE; EC 3.1.1.7) reactivators derived from a monoquaternary reactivator pralidoxime. pralidoxime 153-164 acetylcholinesterase Rattus norvegicus 58-78 17265677-1 2006 This paper describes an in vitro study of three potential acetylcholinesterase (AChE; EC 3.1.1.7) reactivators derived from a monoquaternary reactivator pralidoxime. pralidoxime 153-164 acetylcholinesterase Rattus norvegicus 80-84 16025528-1 2005 In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI-6, trimedoxime, BI-6 and Hlo-7) for reactivation of sarin- and cyclosarin-inhibited AChE using an in vitro reactivation test. pralidoxime 75-86 acetylcholinesterase Rattus norvegicus 55-59 16259317-0 2005 A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. pralidoxime 80-91 acetylcholinesterase Rattus norvegicus 150-170 16259317-1 2005 (1) The efficacy of the oxime HLo7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. pralidoxime 62-73 acetylcholinesterase Rattus norvegicus 106-126 34163757-9 2021 These favorable findings are attributed to synergistic effects that PAM reactivates AChE to hydrolyze ACh and excess ACh is encapsulated in the cavity of CP6A to relieve cholinergic crisis symptoms. pralidoxime 68-71 acetylcholinesterase Rattus norvegicus 84-88