PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3181042-2 1988 The logarithm of the percentage RBC AChE reactivated by 2-PAM after soman exposure was plotted as a function of time. pralidoxime 56-61 acetylcholinesterase Cavia porcellus 36-40 33212192-1 2021 Nerve agent exposure is generally treated by an antidote formulation composed of a muscarinic antagonist, atropine sulfate (ATR), and a reactivator of acetylcholinesterase (AChE) such as pralidoxime, obidoxime (OBI), methoxime, trimedoxime or HI-6 and an anticonvulsant. pralidoxime 187-198 acetylcholinesterase Cavia porcellus 173-177 31954867-3 2020 Three common oximes are available: HI-6, Pralidoxime (2-PAM) and Obidoxime (Obi), all possess a nucleophile that can break the NA-AChE covalent bond. pralidoxime 41-52 acetylcholinesterase Cavia porcellus 130-134 19680820-1 2010 The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4. pralidoxime 269-274 acetylcholinesterase Cavia porcellus 110-130 21989207-1 2011 AIMS: Due to pralidoxime chloride"s (2-PAM) positive charge, it"s penetration through the blood brain barrier (BBB) and reactivation of organophosphate (OP) inhibited central nervous system (CNS) acetylcholinesterase (AChE) is poor. pralidoxime 13-33 acetylcholinesterase Cavia porcellus 196-216 21989207-1 2011 AIMS: Due to pralidoxime chloride"s (2-PAM) positive charge, it"s penetration through the blood brain barrier (BBB) and reactivation of organophosphate (OP) inhibited central nervous system (CNS) acetylcholinesterase (AChE) is poor. pralidoxime 13-33 acetylcholinesterase Cavia porcellus 218-222 20156430-2 2010 Standard OP exposure therapy in the United States consists of atropine sulfate (to block muscarinic receptors), the acetylcholinesterase (AChE) reactivator (oxime) pralidoxime chloride (2-PAM), and a benzodiazepine anticonvulsant to ameliorate seizures. pralidoxime 164-184 acetylcholinesterase Cavia porcellus 138-142 19680820-1 2010 The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLo7, and MMB-4. pralidoxime 269-274 acetylcholinesterase Cavia porcellus 132-136 19763542-1 2009 Methoxime (MMB-4) is a leading candidate oxime acetylcholinesterase (AChE) reactivator to replace pralidoxime (2-PAM) for therapeutic treatment of nerve agent intoxication. pralidoxime 98-109 acetylcholinesterase Cavia porcellus 47-67 19763542-1 2009 Methoxime (MMB-4) is a leading candidate oxime acetylcholinesterase (AChE) reactivator to replace pralidoxime (2-PAM) for therapeutic treatment of nerve agent intoxication. pralidoxime 98-109 acetylcholinesterase Cavia porcellus 69-73 19763542-1 2009 Methoxime (MMB-4) is a leading candidate oxime acetylcholinesterase (AChE) reactivator to replace pralidoxime (2-PAM) for therapeutic treatment of nerve agent intoxication. pralidoxime 111-116 acetylcholinesterase Cavia porcellus 47-67 19763542-1 2009 Methoxime (MMB-4) is a leading candidate oxime acetylcholinesterase (AChE) reactivator to replace pralidoxime (2-PAM) for therapeutic treatment of nerve agent intoxication. pralidoxime 111-116 acetylcholinesterase Cavia porcellus 69-73 19778238-3 2009 Oximes such as 2-PAM are used to reactivate OP-inhibited AChE so as to restore normal enzymatic function and serve as a true antidote. pralidoxime 15-20 acetylcholinesterase Cavia porcellus 57-61